2018 American Transplant Congress
Evaluation of Clinical and Safety Outcomes Following Uncontrolled Tacrolimus Conversion in Adult Transplant Recipients
Background: Long-term studies with control groups are required to assess tacrolimus (TAC) conversion. The purpose of this study was to compare clinical and safety outcomes…2018 American Transplant Congress
Predicting Early and Late eGFR Variability in Kidney Transplant Recipients
Department of Medicine and Department of Surgery, MUSC, Charleston, SC.
Introduction: eGFR variability is a known risk factor for graft loss. It is unclear what modifiable factors are significantly associated with this variability and if…2018 American Transplant Congress
Human Thrombomodulin Expression on Genetically Modified Donor Pigs is Required to Maintain the Anti-Coagulation Profile
Introduction: Coagulation dysregulation is major limitation for xenotransplantation but it is resolved to some extent by making genetically engineered (GE) pigs, which express complement inhibitors…2018 American Transplant Congress
The Influence of a Conversion to Sirolimus-Based Immunosuppression on Non-Melanomatous Skin Cancer Incidence in Kidney Transplant Recipients over Long Term Follow Up
Background: The CONVERT trial found a reduced incidence of malignancy amongst renal transplant recipients over 2 years of follow up with a conversion from calcineurin…2018 American Transplant Congress
Improved Long-Term Outcomes of Pancreas Transplantation: Analysis of Allograft Half-Lives and Predictive Demographic Factors
Department of Surgery Division of Transplantation, University of Minessota, Minneapolis, MN.
In contrast to other solid organ transplants, the characteristics of long term surviving pancreas transplants have not been well described. Our objective was to measure…2018 American Transplant Congress
Evaluation of Allergy to Tacrolimus in Kidney Transplant Candidates and Recipients with a History of Macrolide Antibiotic Allergy
Background: Tacrolimus (TAC) is considered a drug of choice for maintenance immunosuppression among kidney transplant (KTX) recipients. Because of structural resemblances between macrolide antibiotics (azithromycin,…2018 American Transplant Congress
Impact of a Steroid Free Immunosuppressive Regimen on Patient and Graft Outcomes in Pancreas Transplant Recipients
Steroids have been an important component of maintenance immunosuppression in solid organ transplant, but their adverse effect profile has led to the development of steroid…2018 American Transplant Congress
Higher Rates of Rejection in HIV-Infected Kidney Transplant Recipients on Ritonavir-Boosted Protease Inhibitors–Three-Year Follow Up
The Mount Sinai Hospital, New York.
Background: One-year rejection rates in HIV-infected kidney transplant recipients range from 15-40%, compared to overall rejection rates of 10% in HIV-negative patients. Protocols for immunosuppression…2018 American Transplant Congress
Efficacy and Safety of Immediate- and Prolonged-Release Tacrolimus in De Novo Pediatric Transplantation: Randomized Study
This study assessed long-term efficacy/safety of prolonged-release tacrolimus (PR-T) vs immediate-release tacrolimus (IR-T) in de novo pediatric transplant pts. Phase II, parallel-group, multicenter, open-label study…2018 American Transplant Congress
MeltDose Prolonged-Release Once-Daily Tacrolimus (LCPT) vs. Conventional Tacrolimus Formulations in the Initial Maintenance of De Novo Kideny Transplant Recipients across Europe: STEADY Study
Tacrolimus is an immunosuppressant drug available as a twice-daily formulation (Prograf®, IR-Tac), or as once-daily formulations (Advagraf®, PR-Tac; Envarsus®, LCPT). LCPT has shown clinical non-inferiority…
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