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Articles tagged "Immunosuppression"

  • 2018 American Transplant Congress

    Can We Optimise Immunosuppression Strategies in Our Older Renal Transplant Recipients?

    M. Morton,1 K. Parker,1 C. Morecroft.2

    1Manchester University Foundation Trust, Manchester, United Kingdom; 2Liverpool John Moores University, Liverpool, United Kingdom.

    Renal transplantation provides a survival advantage for patients including those with multiple co-morbidities and older age compared to remaining on dialysis. The optimal immunosuppressive regime…
  • 2018 American Transplant Congress

    De Novo Use of Extended Released Tacrolimus (Meltdose, EnvasusR)) after OLT – Does the Colonic Resorption Influences the Outcome?

    T. Soliman, G. Györi, M. Hofmann, A. Salat, S. Rockenschaub, G. Berlakovich.

    Department of Transplantation, Medical University of Vienna, Vienna, Austria.

    Introduction: Immunosuppression after OLT has reached a quite high standard with an excellent evidence base. However, there is still a lack of data for the…
  • 2018 American Transplant Congress

    The Clinical Efficacy of Seasonal Influenza Vaccination – Characteristics of Two Outbreaks of Influenza A(H1N1) in Immunocompromised Patients

    I. Helanterä,1 R. Janes,2 V-.J. Anttila.3

    1Transplantation and Liver Surgery, Helsinki University Hospital, Helsinki, Finland; 2Department of Oncology, Helsinki University Hospital, Helsinki, Finland; 3Department of Infectious Diseases, Helsinki University Hospital, Helsinki, Finland.

    A. Background. Influenza A(H1N1) causes serious complications in immunocompromised patients. The efficacy of seasonal influenza vaccination in transplant recipients and patients receiving chemotherapy has been…
  • 2018 American Transplant Congress

    Outcomes in Liver Transplant Patients on Renal Sparing Protocol

    A. Polyak,1 D. Ganger,2 A. Shetty.2

    1New York Medical College, Valhalla, NY; 2Comprehensive Transplant Center, Northwestern University, Chicago, IL.

    As liver transplant outcomes have improved, long term native kidney function has taken a critical role in patient survival. Calcineurin inhibitors (CNIs), such as Tacrolimus…
  • 2018 American Transplant Congress

    Belatacept in Kidney Transplant Recipients with Preformed Donor Specific Anti-HLA Antibodies: Results of the BELACOR Trial

    C. Leibler,1 F. Canoui,2 M. Matignon,1 E. Rondeau,3 A. Zarour,2 A. Durrbach,4 S. Malard,5 P. Grimbert.1

    1Nephrology Transplantation, APHP Henri Mondor, Creteil, France; 2Public Health, APHP Henri Mondor, Creteil, France; 3Nephrology Transplantation, APHP Tenon, Paris, France; 4Nephrology Transplantation, APHP Bicêtre, Le Kremlin Bicêtre, France; 5Histocompatibility, APHP Saint Louis, Paris, France.

    IntroductionAntibody-mediated rejection (ABMR) is currently a critical question in kidney transplant recipient with immunological risk factors such as pre transplant donor-specific anti HLA antibodies (DSA).…
  • 2018 American Transplant Congress

    Identification of Anti-Inflammatory and Pro-Inflammatory Gut Microbiota That Determine Graft Survival

    Y. Xiong, C. Brinkman, L. Hittle, W. Fricke, E. Mongodin, J. Bromberg.

    UMB, MD.

    Introduction: The gut microbiota induce and train the host immune system. Whether microbiota from contrasting environments of colitic or pregnant mice are pro- or anti-inflammatory…
  • 2018 American Transplant Congress

    Superior Renal Function with CNI-Free Everolimus over Standard CNI-Based Regimen: 18 Months Data from the Randomized, Multi-Center MANDELA Trial in De Novo Heart Transplant Recipients

    M. J. Barten,1 S. W. Hirt,1 J. Garbade,1 C. Bara,1 A. Doesch,1 C. Knosalla,1 C. Grinninger,1 J. Stypmann,1 C. Sieder,2 M. Junge,2 U. Schulz.1

    1Mandela Study Group, Germany; 2Novartis, Pharma, Germany.

    Purpose: The MANDELA study (NCT00862979) was designed to assess the benefit on renal function of either CNI-free or CNI-minimized EVR-based regimen after early conversion of…
  • 2018 American Transplant Congress

    Association of Tacrolimus Adherence and Discontinuation with Sepsis Risk among Kidney Transplant Recipients

    J. Donnelly,1 P. MacLennan,1 R. Mannon,1 R. Saran,2 J. Baddley,1 H. Wang,3 G. McGwin, Jr.,1 P. Muntner.1

    1University of Alabama at Birmingham, Birmingham, AL; 2University of Michigan, Ann Arbor, MI; 3University of Texas Health Science Center, Houston, TX.

    OBJECTIVE: The association between post-transplant tacrolimus exposure and sepsis risk is currently unknown. We examined the associations of tacrolimus adherence and discontinuation with sepsis risk…
  • 2018 American Transplant Congress

    Human CD8+CD28– Ts Cells Expanded by Common Gamma Chain (γc) Cytokines Keep Steady Allospecific Suppressive Capacity In Vivo

    G. Liu,1 F. Feng,1 P. Zhu,1 J. Liu,2 Y. Liu,1 Y. Yu.2

    1Department of Immunology, School of Basic Medical Science, Southern Medical University, Guangzhou, Guangdong, China; 2Department of Urology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.

    Background: CD8+CD28- T suppressor (Ts) cells were recently reported to play a critical role in transplant tolerance, harnessing the potential for clinical use in transplantation.…
  • 2018 American Transplant Congress

    Risk of Bacteremia According to Transplant Induction Immunosuppression Regimen

    E. Misch, S. Kelley, G. Leverson, B. Astor, D. Kaufman.

    University of Wisconsin School of Medicine and Public Health, Madison.

    Background: Transplant immune suppression is designed to suppress the adaptive immune response and ensure graft survival, but may have unintended effects on innate immunity. Few…
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