Articles tagged "Immunosuppression"

2018 American Transplant Congress
Time in Therapeutic Range Predicts DSA Development and Acute Rejection in Kidney Recipients with High Tacrolimus Coefficient of Variation
S. Davis, J. Gralla, P. Klem, A. Wiseman, J. Cooper.
University of Colorado, Aurora, CO.
High tacrolimus trough coefficient of variation (TAC CV) has been associated with an increased risk of de novo donor-specific antibody (dnDSA) and acute rejection (AR).…
2018 American Transplant Congress
CD19+ Cell Ratio as a Predictive Marker of Antibody Mediated Rejection in ABO Incompatible Kidney Transplantation
K. Unagami,¹ R. Maenosono,² M. Furusawa,² Y. Kakuta,² M. Okumi,² H. Ishida,² K. Tanabe,² K. Nitta.¹
¹Nephrology, Tokyo Women's Medical University, Tokyo, Japan; ²Urology, Tokyo Women's Medical University, Tokyo, Japan.
Background: Rituximab has been suggested to deplete B cells and decrease the possibility of antibody mediated rejection (AMR) in ABO-incompatible living kidney transplantation (ABO-ILKT). We…
2018 American Transplant Congress
Predictors of Immunosuppressive Medication Adherence in Chinese Renal Transplant Recipients: Marital Status and Immunosuppressive Medication Beliefs
J. Liu,¹ S. Liu,² J. Xie,¹ J. Yan.¹
¹The Third Affiliated Hospital, Central South University, Changsha, China; ²Adelphi University College of Nursing and Public Health, Garden City, NY.
Purpose: Our aim was to examine the beliefs on immunosuppressive medication (IM) and IM adherence in Chinese renal transplant recipients, and explore the predictors of…
2018 American Transplant Congress
Immunosuppression and the Risk of Dementia among Older Kidney Transplant Recipients
M. McAdams DeMarco,¹ C. Haugen,¹ S. Bae,¹ K. Lentine,² D. Segev.¹
¹JHU, Baltimore; ²SLU, St. Louis.
Background: Older recipients have a high burden of dementia after kidney transplantation (KT). Factors contributing to post-KT dementia may include long-standing kidney disease, comorbid vascular…
2018 American Transplant Congress
Automated Systems to Identify and Address Adherence Barriers Result in Sustained Reduction of Late Allograft Rejection
D. Hooper, C. Varnell, Jr., K. Rich, J. Huber, D. Dahale, A. Carle, A. Pai, A. Modi.
Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Background: Patient-identified barriers to taking immunosuppressive medications are associated with rejection and allograft loss, yet interventions targeting adherence barriers are rarely integrated into clinical practice.…
2018 American Transplant Congress
Sirolimus-Based, Prednisone-Free Regimen in Kidney Transplantation: Long Term Results of an Open-Label, Randomized Controlled Trial
A. Shetty,¹ B. Ho,¹ V. Mas,² Y. Kassis,¹ S. Park,¹ J. Leventhal,¹ D. Chhabra,³ L. Gallon.¹
¹Northwestern University, Chicago; ²University of Virginia, Charlottesville; ³Advocate Christ Medical Center, Chicago.
Background: Calcineurin (CNI) nephrotoxicity is implicated in chronic allograft dysfunction and presents an argument for CNI minimizing immunosuppression. We assessed the long-term effects of CNI…
2018 American Transplant Congress
Efficacy and Safety of a Single-Dose Rituximab for Prevention of Focal Segmental Glomerulosclerosis Recurrence after Kidney Transplant
Y. Lu,¹ J. Lyons,² S. Tischer,² K. Woodside,³ J. Park.²
¹Transplant Nephrology, University of Michigan, Ann Arbor, MI; ²Transplant Pharmacy, University of Michigan, Ann Arbor, MI; ³Transplant Surgery, University of Michigan, Ann Arbor, MI.
Background: For patients with end stage renal disease (ESRD) due to primary focal segmental glomerulosclerosis (FSGS), there is a significantly increased risk for disease recurrence…
2018 American Transplant Congress
Mycophenolate Monotherapy is Safe and Effective in HLA-Matched Kidney Transplant Recipients
A. Hennes, K. Holdener, W. Burlingham, B. Astor, A. Djamali.
UW Health, Madison, WI.
Purpose: The ideal minimizing strategy for maintenance immunosuppression in HLA-matched kidney transplant recipients (KTR) is unknown. We hypothesized that mycophenolate (MPA) monotherapy is a safe…
2018 American Transplant Congress
Evaluation of Survival and Maintenance Immunosuppression in Elderly Lung Transplant Recipients
P. Nguyen,¹ R. Girgis,^1,2 E. Murphy,^1,2 R. Hadley,^1,2 M. Leacche,^1,2 A. Kumar,^1,2 G. Sathiyamoorthy,^1,2 J. McDermott.^1,2
¹Spectrum Health, Grand Rapids, MI; ²Michigan State University College of Human Medicine, Grand Rapids, MI.
Background: Lung transplantation in the elderly is controversial given increased risks and the optimal immunosuppression regimen is not fully understood.Methods: A retrospective cohort study was…
2018 American Transplant Congress
Immune Modulatory Effect of Thalidomide and Dexamethasone Co-Treatment on Murine Splenocytes
E. Kim,^1,2 J. Kim,¹ K. Huh,^1,3 Y. Cho,¹ M. Kim,^1,3 Y. Kim,^1,3 B. Kim.^1,4
¹The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea; ²Brain Korea 21 PLUS Project for Medical Science, Yonsei University, Seoul, Korea; ³Department of Transplantation Surgery, Yonsei University College of Medicine, Seoul, Korea; ⁴Department of Internal Medicine, Nephrology, Yonsei University College of Medicine, Seoul, Korea.
Thalidomide (TM) is known to have anti-inflammatory effects and dexamethasone (DX) is also well known to reduce inflammation and inhibit inflammatory cytokine production. Clinically, combinatorial…