ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Immunosuppression"

  • 2022 American Transplant Congress

    Standard Induction with Basiliximab versus no Induction in Low Immunological Risk Kidney Transplant Recipients: Study Protocol for a Randomized Controlled Trial

    A. Ajlan1, H. Aleid1, T. Ali1, H. Joharji1, Z. Alabdulkarim1, T. Aburiash1, K. Almeshari1, A. Nazmi1, Y. Shah1, E. Devol1, D. Alkortas1, D. Broering1, I. Alahmadi1, A. Ullah1, A. Alotaibi1, A. Aljedai2

    1KFSHRC, RIYADH, Saudi Arabia, 2MOH, RIYADH, Saudi Arabia

    *Purpose: To compare different induction therapeutic strategies with 2 doses of basiliximab vs. no induction in low immunologic risk kidney transplant recipients as per KFSHRC…
  • 2022 American Transplant Congress

    Impact of Belatacept on Clinical Outcomes in Lung Transplant Patients with Antibody-Mediated Rejection

    L. Zaffiri, R. Hallak, S. Leonard, M. Neely, A. Hulber, H. Berry, K. A. Young, J. M. Reynolds

    Duke University, Durham, NC

    *Purpose: Antibody-mediated rejection (AMR) is cause of significant morbidity and mortality in lung transplant recipients (LTRs). An optimal therapeutic regimen is still lacking. Recent evidence…
  • 2022 American Transplant Congress

    Induction of Tacrolimus Clearance by Steroids Varies by Cyp3a5 Genotype in Kidney Transplant Recipients: A Drug-Drug-Gene Interaction

    P. A. Jacobson1, A. Saqr1, M. Al-Kofahi1, D. P. Schladt2, W. Guan3, W. S. Oetting1, R. Mannon4, C. R. Dorr5, R. P. Remmel1, G. C. Onyeaghala6, B. Wu3, A. K. Israni7, A. Matas8

    1Univ of MN, College of Pharmacy, Minneapolis, MN, 2Hennepin Health Research Institute, Minneapolis, MN, 3Univ of MN, Biostatistics, Minneapolis, MN, 4Univ of Nebraska, Dept of Medicine, Omaha, NE, 5Hennepin Health Research Institute and Dept of Medicine, Minneapolis, MN, 6Hennepin Healthcare Research Institute, Minneapolis, MN, 7Hennepin Health Dept of Medicine and Univ of MN, Minneapolis, MN, 8University of MN, Dept of Surgery, Minneapolis, MN

    *Purpose: Tacrolimus (TAC) is the primary immunosuppressant used in organ transplantation. TAC is a substrate for CYP3A4/5. These enzymes are inhibited or induced by multiple…
  • 2022 American Transplant Congress

    Viral-Specific Cytotoxic T-Cell Responses in Hla-Sensitized Kidney Transplant Patients Maintained on Everolimus and Low Dose Tacrolimus

    R. Zhang1, S. Ge1, M. Chu1, J. Kahwaji2, A. Karasyov1, D. Lovato1, A. Vo2, J. Choi2, M. Toyoda1, S. Jordan2

    1Transplant Immunology Laboratory, Cedars Sinai Medical Center, Los Angeles, CA, 2Comprehensive Transplant Center, Cedars Sinai Medical Center, Los Angeles, CA

    *Purpose: Post-transplant immunosuppression with “everolimus + reduced dose tacrolimus” (Ev + Taclow) is reported to reduce the risk of viral infections compared to standard doses…
  • 2022 American Transplant Congress

    The Successful Use of De Novo Belatacept with Reduced Dose Tacrolimus to Mitigate the Risks of Delayed Graft Function in Kidney Transplantation

    E. Siskind1, J. Splinter1, C. Taing1, A. Adekile2, S. Njim1, S. Shah1, R. Plews3, D. Conti4, S. Patel2

    1Center for Transplantation, University Medical Center of Southern Nevada, Las Vegas, NV, 2University Medical Center of Southern Nevada, Las Vegas, NV, 3Center for Transplantation, Albany Medical Center, Albany, NY, 4Albany Medical Center, Albany, NY

    *Purpose: The new kidney allocation system has caused increased organ travel times and therefore increased cold ischemia time. Furthermore, the change in the priority to…
  • 2022 American Transplant Congress

    Impact of Target Tacrolimus Levels on BK Polyomavirus DNAemia and Allograft Rejection Among Pediatric Kidney Transplant Recipients

    H. Huang1, P. Winterberg1, R. George1, A. Serluco2, R. Liverman2, I. Yildirim3, R. Garro1

    1Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, 2Children's Healthcare of Atlanta, Atlanta, GA, 3Yale University School of Medicine, New Haven, CT

    *Purpose: BK Polyomavirus (BK) DNAemia is a serious and common infectious complication after kidney transplant (KT). We evaluated the impact of targeting lower tacrolimus levels…
  • 2022 American Transplant Congress

    Induction Immunosuppression Does Not Worsen Tumor Recurrence After Liver Transplantation for T2 Hepatocellular Carcinoma and May Allow for Decreased Mortality

    C. Durkin1, T. Bittermann1, D. E. Schaubel2

    1Gastroenterology, University of Pennsylvania, Philadelphia, PA, 2Biostatistics, University of Pennsylvania, Philadelphia, PA

    *Purpose: Prior studies have suggested that induction therapy leads to worse outcomes after liver transplantation (LT) for hepatocellular carcinoma (HCC). This study evaluated the impact…
  • 2022 American Transplant Congress

    Impact of Glecaprevir/Pibrentasvir on Tacrolimus Concentration in Solid Organ Transplant Recipients with or without Triazole Antifungal Therapy

    D. Abraham1, A. Feist2, N. Law1, S. Aslam1, V. Nguyen1

    1University of California San Diego Health, San Diego, CA, 2University of California San Diego, San Diego, CA

    *Purpose: Provide guidance on tacrolimus (TAC) dose adjustments during glecaprevir/pibrentasvir (GLE/PIB) initiation and discontinuation in patients on triazole antifungals by comparing changes in TAC concentration-dose…
  • 2022 American Transplant Congress

    A Low Immuknow Level but Behold….pAMR1(H+) Rejection

    M. W. Weston

    Tampa General Hospital, Tampa, FL

    *Purpose: PURPOSE: The purpose of this study is to evaluate the mechanism of pAMR1(H+) rejection in heart transplant recipients with low ImmuKnow levels (ATP
  • 2022 American Transplant Congress

    Association Between Maintenance Immunosuppressive Regimens And Covid-19 Mortality In Kidney Transplant Recipients

    A. O. Gérard1, S. Barbosa2, D. Anglicheau3, L. Couzi4, M. Hazzan5, O. Thaunat6, G. Blancho7, S. Caillard8, A. Sicard1

    1Nephrology, Nice University Hospital, Nice, France, 2Institute of Molecular and Cellular Pharmacology, CNRS, Valbonne, France, 3Nephrology, Necker University Hospital, APHP, Paris, France, 4Nephrology, Bordeaux Pellegrin University Hospital, Bordeaux, France, 5Nephrology, Lille University Hospital, Lille, France, 6Nephrology, Edouard Herriot Hospital, Hospices civils de Lyon, Lyon, France, 7Nephrology, Nantes University Hospital, Nantes, France, 8Nephrology, Strasbourg University Hospital, Strasbourg, France

    *Purpose: Kidney transplant recipients (KTR) are at increased risk of mortality from COVID-19. We conducted a cohort study among KTR from the French Solid Organ…
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