2022 American Transplant Congress
Impact of Immunosuppressive Medications on SARS-CoV-2 Vaccination Response in Kidney Transplant Patients
*Purpose: The COVID-19 pandemic portends significant morbidity and mortality in immunocompromised individuals. Vaccination against COVID-19 among immunocompromised population is an essential step to minimize deadly…2022 American Transplant Congress
Recipient and Grafts Outcomes in Simultaneous Kidney and Pancreas Transplantation with Steroid Avoidance in the United States
*Purpose: Steroid avoidance in kidney transplantation has been proven non-inferior. Data on steroid avoidance in simultaneous pancreas-kidney (SPK) is scant.*Methods: We utilized the Scientific Registry…2022 American Transplant Congress
Use of Dd-cfdna to Guide Tapering of Immunosuppression Therapy in Kidney Transplant Recipients
1Victoria Kidney and Dialysis Associates, Victoria, TX, 2Natera, Inc., Austin, TX
*Purpose: Continuous administration of immunosuppressive therapy (IST) is required to avoid allograft rejection in transplant recipients. However, these therapeutic interventions can lead to significant side…2022 American Transplant Congress
How Does Anti-CD38 Antibody Treatment (Daratumumab) Impact Immunological Assessment in Solid Organ Transplantation?
*Purpose: We report the first case of Dara interference of routine pre-transplant (Tx) crossmatch (XM) repeatedly causing aberrant false positives which inadvertently delayed Tx for…2022 American Transplant Congress
An Immune-Modulatory Strategy to Mitigate Hepatic Ischemia Reperfusion Injury in a Murine Model
University of Florida, Gainesville, FL
*Purpose: Hepatic ischemia/reperfusion injury (IRI) is the leading cause of early graft dysfunction and contributes to the shortage of donor liver grafts. However, despite its…2022 American Transplant Congress
Is a Single Dose of Steroids in Adult Living Donor Liver Transplant Safe? – A Cohort Analysis
University of California San Francisco, San Francisco, CA
*Purpose: Steroids increase morbidity, and steroid avoidance (SA) has been studied in deceased donor liver transplant but, little is known about SA in living donor…2022 American Transplant Congress
PSGL-1-mTOR-TIM3 Signaling in a Murine Model of Hindlimb Transplantation
*Purpose: Peri-transplant tissue damage driven by innate-adaptive immune cascades resulting from ischemia-reperfusion injury (IRI) is a major concern in vascularized composite allotransplantation (VCA). Here, we…2022 American Transplant Congress
Low T Cell Responsiveness in the Early Phase Of COVID-19 Associates with Progression to Severe Pneumonia in Kidney Transplant Recipients
*Purpose: Kidney transplant (KT) recipients are more prone to developing life-threatening forms of COVID-19 than the general population. Little is known about the immunological mechanisms…2022 American Transplant Congress
Clinical Stratification of Pediatric Liver Transplant Recipients 4-5 Years Post-Transplant: 1St Step Towards Personalized Management
*Purpose: Recent surveillance biopsy studies strongly associate high normal ALT (>35U/L) with inflammatory histopathology and low normal ALT (15yrs (n=13; p=0.0006), chronic rejection (CR) diagnosis…2022 American Transplant Congress
Adoptive Transfer OfMesenchymal Stem Cells Activates Hedgehog/SMO/Gli1 Signaling And Inhibits STING-mediated Innate Immune Response In Liver Transplant Inflammatory Injury
*Purpose: The stimulator of interferon genes (STING) pathway has been recognized as a crucial signaling cascade of the innate immune system. Activation of the Hedgehog…
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