2018 American Transplant Congress
Long-Term Effects of Ketoconazole in Rapid Tacrolimus Metabolizers Post-Renal Transplantation
Introduction: Genetic polymorphisms in cytochrome P-450 enzymes can cause variations in tacrolimus (tac) metabolism. Ketoconazole (keto), a potent CYP450 and P-glycoprotein inhibitor, can be used…2018 American Transplant Congress
Novel Low Dosing of Rabbit Antithymocyte Globulin Preserves Excellent Outcomes and Improves the Value of Care in Low Risk Renal Transplantation
University of Virginia Health System, Charlottesville, VA.
Elderly and non-sensitized renal transplant patients may benefit from lesser induction immunosuppression. This study evaluates three year clinical outcomes of a low risk renal transplant…2018 American Transplant Congress
Adjunctive Corticosteroid Immunosuppression Improves Hyperbilirubinemia Following Liver Transplantation (OLT)
Drexel University, Philadelphia.
Background: Deceased donor orthotopic liver transplantation (OLT) can result in significant delayed function, manifesting as protracted hyperbilirubinemia, depending on the intensity of the ischemia/reperfusion injury…2018 American Transplant Congress
Mycophenolic Acid Reduces BK Polyomavirus Replication in an In Vitro Model of Renal Tubular Epithelial Cells Infection
Background. BK virus (BKV) nephropathy is an important cause of allograft failure after kidney transplant. Immunosuppression is a recognized risk factor for BKV replication but…2018 American Transplant Congress
Effect of Everolimus with Reduced Calcineurin Inhibitor on Efficacy and Safety in De Novo Kidney Transplant Recipients: 12-Month Results from the US Cohort of TRANSFORM Study
1TRANSFORM Study Group, Livingston; 2Novartis Pharmaceuticals Corporation, East Hanover.
Purpose: Despite remarkable short-term survival benefits, long-term outcomes in kidney transplant recipients (KTRs) remain unsatisfactory. Everolimus (EVR) may improve long-term outcomes by reducing calcineurin inhibitor…2018 American Transplant Congress
Approaches to Prevention of Antibody Rebound after HLA Sensitization in a Mouse Model
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Purpose: Control of donor specific antibodies (DSA) is critical for prevention of antibody mediated rejection (ABMR). Removal of DSAs with PLEX often results in significant…2018 American Transplant Congress
Early Steroid Withdrawal and Kidney Transplant Outcomes for Recipients with Delayed Graft Function
Current guidelines suggest early steroid withdrawal (ESW) regimen for kidney transplant (KT) recipients with low immunological risk. Delayed graft function (DGF) is a risk factor…2018 American Transplant Congress
The Impact of Childhood Solid Organ Transplantation on B-Cell Maturation
Background:The developing immune system of childhood promotes better graft acceptance and longevity but also higher risk for infections and post-transplant (Tx) lymphoproliferative disorders. This may…2018 American Transplant Congress
Influence of mTOR Inhibitors on Metabolic Outcomes One Year after Kidney Transplantation: The Role of Pre-Transplantation Diabetes
INTRODUCTION: mTOR inhibitors alter lipids and carbohydrate metabolism in kidney transplant recipients. Little is known if there is any difference between patients who were already…2018 American Transplant Congress
Genome-Wide Association Study of Tacrolimus Dose in Pediatric Solid Organ Transplant Recipients in the CNTRP POSITIVE Study
PURPOSE: There are significant challenges in achieving therapeutic tacrolimus (Tac) concentrations after transplant. We explored variants associated with tacrolimus dose requirements in pediatric solid organ…
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