Articles tagged "Immunosuppression"

2018 American Transplant Congress
Targeting Calcium Release-Activated Calcium (CRAC) Channel in Non-Human Primate Kidney Transplantation
J. Kwun,¹ B. Ezekian,¹ M. Manook,¹ J. Park,¹ J. Yoon,¹ J. Sloan-Lancaster,² C. Fortier,³ P. Rao,⁴ S. Knechtle.¹
¹Surgery, Duke University, Durham, NC; ²Eli Lilly and Company, Indianapolis, IN, Canada; ³PRCL Research Inc, Montreal, QC, Canada; ⁴Synta Pharmaceuticals Inc., Lexington, MA.
[Background] Long-term administration of calcineurin inhibitors (CNIs) successfully controls rejection of transplanted organs. However, the chronic use of these drugs causes organ damage often resulting…
2018 American Transplant Congress
Treatment of Post Transplant Hepatitis C (HCV) with Direct-Acting Antiviral (DAA) Agents May Improve Liver Function but Does Not Lead to an Increase in Liver Rejection
P. Sheiner, N. Mello, G. Baixauli, M. Einstein, C. Rochon, Y. Kwon, M. Bejon.
Surgery, Hartford Hospital, Hartford, CT.
Previous studies have suggested that with the use of with (DAA) agents to treat post transplant (HCV), there has been an increased incidence of liver…
2018 American Transplant Congress
Survey of Rabbit Anti-Thymocyte Globulin Usage for Kidney Transplant Induction Therapy in the United States
K. Foster,¹ A. Dodson,² K. Gutierrez.²
¹Samford University McWhorter School of Pharmacy, Birmingham, AL; ²Comprehensive Transplant Institute, UAB Hospital, Birmingham, AL.
Background: Rabbit anti-thymocyte globulin (rATG) has become the most widely used induction agent in kidney transplantation (KTx) and has recently received FDA approval for this…
2018 American Transplant Congress
Time in Therapeutic Range Predicts DSA Development and Acute Rejection in Kidney Recipients with High Tacrolimus Coefficient of Variation
S. Davis, J. Gralla, P. Klem, A. Wiseman, J. Cooper.
University of Colorado, Aurora, CO.
High tacrolimus trough coefficient of variation (TAC CV) has been associated with an increased risk of de novo donor-specific antibody (dnDSA) and acute rejection (AR).…
2018 American Transplant Congress
CD19+ Cell Ratio as a Predictive Marker of Antibody Mediated Rejection in ABO Incompatible Kidney Transplantation
K. Unagami,¹ R. Maenosono,² M. Furusawa,² Y. Kakuta,² M. Okumi,² H. Ishida,² K. Tanabe,² K. Nitta.¹
¹Nephrology, Tokyo Women's Medical University, Tokyo, Japan; ²Urology, Tokyo Women's Medical University, Tokyo, Japan.
Background: Rituximab has been suggested to deplete B cells and decrease the possibility of antibody mediated rejection (AMR) in ABO-incompatible living kidney transplantation (ABO-ILKT). We…
2018 American Transplant Congress
Predictors of Immunosuppressive Medication Adherence in Chinese Renal Transplant Recipients: Marital Status and Immunosuppressive Medication Beliefs
J. Liu,¹ S. Liu,² J. Xie,¹ J. Yan.¹
¹The Third Affiliated Hospital, Central South University, Changsha, China; ²Adelphi University College of Nursing and Public Health, Garden City, NY.
Purpose: Our aim was to examine the beliefs on immunosuppressive medication (IM) and IM adherence in Chinese renal transplant recipients, and explore the predictors of…
2018 American Transplant Congress
Lymphocyte Proportions Post Thymectomy Are Associated with Allergic Disorders in Heart Transplanted Children
T. Kim,¹ L. Ionescu,^1,2,3 N. Avdimiretz,⁴ M. Larsen,^1,2,3 F. Murdoch,^1,2 B. Motyka,^1,2,3 S. Gilmour,^1,2 L. West,^1,2,3 S. Urschel.^1,2,3
¹Pediatrics, University of Alberta, Edmonton, AB, Canada; ²Stollery Children's Hospital, Edmonton, AB, Canada; ³Alberta Transplant Institute, Edmonton, Canada; ⁴The Hospital for Sick Children, Toronto, Canada.
Background: Allergic disorders are more common in pediatric heart transplant (HTx) recipients than non-transplanted children, with young age at HTx and thymectomy being risk factors.…
2018 American Transplant Congress
Creatinine Monitoring by Remote Blood Spot Testing in Pediatric Kidney Transplant Recipients
J. Dickerson,¹ K. Jacot,² M. Sinkey,² J. Smith.³
¹Laboratory Medicine, Seattle Children's, Seattle; ²Transplant, Seattle Children's, Seattle; ³Pediatrics, University of Washington, Seattle.
Introduction: Pediatric kidney transplant patients are monitored frequently with laboratory testing to assess kidney transplant function and to optimize therapeutic drug levels. Challenges to timely…
2018 American Transplant Congress
Everolimus and the Risk of Graft Loss or Death in Kidney Transplant Recipients: A Trial-Based Linkage Study
T. Ying,^1,2 G. Wong, W. Lim, G. Russ, H. Pilmore, J. Kanellis, D. Goodman, P. Trevillian, S. Campbell, M. Suranyi, M. Mathew, R. Faull, R. Masterson, R. Walker, P. O'Connell, S. Chadban.^1,2
¹Renal Medicine, Royal Prince Alfred Hospital, Camperdown, Australia; ²Kidney Node, Charles Perkins Centre, University of Sydney, Sydney, Australia.
Background: The use of mTORIs may be associated with a reduction of cancer incidence after kidney transplantation (KT) and improved graft function compared with calcineurin-inhibitor…
2018 American Transplant Congress
Long Term Outcomes of a Steroid Free, Low Dose Tacrolimus with Everolimus Regimen in Kidney Transplant
Y. Kassis,¹ S. Park,¹ A. Shetty,¹ J. Leventhal,¹ V. Mas,² L. Gallon.¹
¹Comprehensive Transplant Center, Northwestern University, Chicago, IL; ²Department of Surgery, University of Virginia, Charlottesville, VA.
Tacrolimus (Tac) is the most effective immunosuppressive agent to prevent acute allograft rejection. However, long-term transplant (Tx) outcomes are limited, at least in part, by…