Articles tagged "Immunosuppression"

2018 American Transplant Congress
Long Term Outcomes of a Steroid Free, Low Dose Tacrolimus with Everolimus Regimen in Kidney Transplant
Y. Kassis,¹ S. Park,¹ A. Shetty,¹ J. Leventhal,¹ V. Mas,² L. Gallon.¹
¹Comprehensive Transplant Center, Northwestern University, Chicago, IL; ²Department of Surgery, University of Virginia, Charlottesville, VA.
Tacrolimus (Tac) is the most effective immunosuppressive agent to prevent acute allograft rejection. However, long-term transplant (Tx) outcomes are limited, at least in part, by…
2018 American Transplant Congress
β-Glucuronidase Gene Expression in Stool Samples Associated with Chronic Allograft Dysfunction in Kidney Transplants
A. Israni,^1,2 D. Knights,³ G. Al-Ghalith,³ A. Muthusamy,² B. Wu,⁴ W. Oetting,⁵ D. Schaldt,² R. Remmel,⁵ P. Jacobson,⁵ For DeKAF Genomics & GEN03 Investigators.¹
¹Medicine, HCMC, University of MN (UMN), Minneapolis; ²Minneapolis Medical Research Foundation (MMRF), Mpls; ³Computer Science, UMN, Mpls; ⁴Biostatistics, UMN, Mpls; ⁵College of Pharmacy, UMN, Mpls.
Background: Myocophenolate mofetil (MMF) is a prodrug that is extensively and rapidly converted to the active component, mycophenolic acid (MPA). MPA undergoes extensive enterohepatic recycling…
2018 American Transplant Congress
Evaluation of Immunosuppression and Infection after Desensitization in Lung Transplantation
S. Hammad, B. Ravichandran, J. Kim, D. KuKuruga, S. Cipriano, Z. Kon.
University of Maryland Medical Center, Baltimore.
Purpose: To reduce waitlist time for sensitized lung transplant recipients (LTR), our center used peri-operative desensitization for LTR with a positive virtual crossmatch (P-VXM). We…
2018 American Transplant Congress
A Natural Herb Danshen Suppresses Allospecific Memory CD8+ T Cell Generation and Murine Allograft Rejection
Z. Dai, H. Liu, Y. Chen, C-.L. Liang, F. Qiu.
Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
Inducing long-term transplant survival or tolerance without continuous global immunosuppression is a highly desired goal in transplantation given that conventional immunosuppressive drugs may cause side…
2018 American Transplant Congress
Clinical Application of Mesenchymal Stromal Cells with a Simplified Protocol for ABO Incompatible Liver Transplantation in Severe Hepatic Failure Patients
Y. Zhang,^1,2 J. Zheng,^1,2 J. Cai,^1,2 J. Zhang,^1,2 K. Zeng,^1,2 J. Yao,^1,2 Y. Yang.^1,2
¹Department of Hepatic Surgery and Liver Transplantation Center of the Third Affiliated Hospital, Organ Transplantation Institute, Sun Yat-sen University, Guangzhou, Guangdong, China; ²Guangdong Key Laboratory of Liver Disease Research, Key Laboratory of Liver Disease Biotherapy and Translational Medicine of Guangdong Higher Education Institutes, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, .
Objective The purpose of this study was to test the safety and efficacy of mesenchymal stromal cells (MSCs) treatment with a simplified protocol for ABO…
2018 American Transplant Congress
Impact of Single Nucleotide Polymorphisms on P450 Oxidoreductase and Peroxisome Proliferator-Activated Receptor alpha on Tacrolimus Pharmacokinetics in Renal Transplant Recipients
Z. Wang, Z. Han, J. Tao, H. Chen, S. Li, R. Tan, M. Gu.
Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
The P450 oxidoreductase (POR) and peroxisome proliferator-activated receptor alpha (PPARA) genes have been reported to be associated with the activity of cytochrome P450 enzymes in…
2018 American Transplant Congress
Tacrolimus Metabolism in Subjects with Potentially Absent CYP3A Activity
A. Scheibner,¹ R. Remmel,² D. Schladt,³ W. Oetting,¹ W. Guan,⁴ B. Wu,⁴ C. Door,⁵ A. Israni,⁵ P. Jacobson.¹
¹Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN; ²Medicinal Chemistry, University of Minnesota, Minneapolis, MN; ³Minneapolis Medical Research Foundation, Hennepin County Medical Center, Minneapolis, MN; ⁴Biostatistics, University of Minnesota, Minneapolis, MN; ⁵Department of Medicine, Hennepin County Medical Center, Minneapolis, MN.
Purpose: Tacrolimus (TAC) is a well-known cytochrome P450 (CYP) 3A4 and 3A5 substrate. Common single nucleotide polymorphisms (SNPs) in these genes are significantly related to…
2018 American Transplant Congress
Decreased Clinical Significance of Isoagglutinin Titer with the Current Desensitization Protocol in ABO-Incompatible Kidney Transplantation
C. Baek, H. Kim, W. Yang, D. Han, S-.K. Park.
Department of Internal Medicine, Division of Nephrology, Asan Medical Center, Seoul, Republic of Korea; Department of Surgery, Asan Medical Center, Seoul, Republic of Korea.
ABO-incompatible (ABOi) kidney transplantation (KT) has become a routine procedure with graft survival rates comparable to those of ABO-compatible KT. However, the clinical significance of…
2018 American Transplant Congress
Evolutive Analysis of a 20-Year Pancreas Transplant Program
M. Perosa,¹ J. Branez,¹ L. Mota,¹ H. Noujaim,¹ B. Zeballos,¹ L. Ianhez,¹ L. Alvim,¹ D. Machado,¹ C. Watanabe,¹ F. Sergi,¹ M. Paredes,¹ T. Genzini-Miranda,² A. Silvestre,³ G. Martinho,⁴ T. Genzini.¹
¹Abdominal Organ Transplantation, Leforte Hospital, Sao Paulo, Brazil; ²Medical School, PUC Sorocaba, Sorocaba, Sao Paulo, Brazil; ³Medical School, Sao Camilo, Sao Paulo, Brazil; ⁴Medical School, Ciências Médicas Santa Casa, Sao Paulo, Brazil.
There is a worldwide trend towards a reduction in the annual number of pancreas transplants (PT). In Brazil, only two centers have performed more than…
2018 American Transplant Congress
Immunosuppression and the Risk of Dementia among Older Kidney Transplant Recipients
M. McAdams DeMarco,¹ C. Haugen,¹ S. Bae,¹ K. Lentine,² D. Segev.¹
¹JHU, Baltimore; ²SLU, St. Louis.
Background: Older recipients have a high burden of dementia after kidney transplantation (KT). Factors contributing to post-KT dementia may include long-standing kidney disease, comorbid vascular…