Articles tagged "Immunosuppression"

2018 American Transplant Congress
Prolonged-Release Tacrolimus Dosing in De Novo Kidney Transplantation: Randomized, Open-Label, Pilot Study
Y. Kim,¹ Y. Chiang,² S. Kim,³ M. Kim,⁴ S. Park,⁵ S. Wu,⁶ K. Horita,⁷ Y. Nakashima,⁷ H. Jiang,⁸ D. Han.¹
¹Asan Medical Center, Seoul, Korea; ²Chang Gung Memorial Hospital-Linkou, Taoyuan City, Taiwan; ³Samsung Medical Center, Seoul, Korea; ⁴Severance Hospital, Seoul, Korea; ⁵Dongsan Medical Center, Daegu, Korea; ⁶Tri-Service General Hospital, Taipei City, Taiwan; ⁷Astellas Pharma, Inc., Tokyo, Japan; ⁸Astellas Pharma, Inc., Maao, Singapore.
A multicenter, randomized, open-label, parallel-group, pilot, 52-wk study in Asian countries that assessed renal function, efficacy, and safety of low vs standard-dose prolonged-release tacrolimus (PRT)…
2018 American Transplant Congress
Regulation of NK Cell Cytotoxicity by TEC Expression of Clr Proteins in Kidney Ischemia Reperfusion Injury (IRI)
B. Fuhrmann,^1,5 D. Lian,⁵ Z. Yin,⁵ S. Ma,^4,5 J. Arp,⁵ Z. Zhang,^2,3,4,5 A. Jevnikar.^1,3,4,5
¹Microbiology and Immunology, Western University, London, Canada; ²Pathology, Western University, London, Canada; ³Medicine, Western University, London, Canada; ⁴Multi-Organ Transplant Program, London Health Sciences Centre, London, Canada; ⁵Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, Canada.
Background: Kidney tubular epithelial cells (TEC) may negatively regulate NK cell activation and cytotoxic capacity by surface expression of a novel class of C-type lectin-related…
2018 American Transplant Congress
High Calcineurin Inhibitor Intra Patient Variability is Associated with Early Renal Allograft Inflammation, Chronicity and Loss
A. Sharma,¹ A. Cherukuri,² R. Mehta,¹ P. Sood,¹ S. Hariharan.¹
¹Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA; ²Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.
High CNI IPV has been associated with poor kidney allograft outcomes, albeit in small limited studies. We evaluated effect of CNI IPV (the degree of…
2018 American Transplant Congress
Increased Pre-Transplant Rejection-Risk Measured with Allospecific T-Cells Predicts Delayed Immunosuppression Minimization in Children with Intestine Transplantation.
K. Soltys, C. Ashokkumar, G. Mazariegos, G. Bond, M. Ningappa, A. Khanna, A. Ganoza, Q. Sun, R. Sindhi.
Pediatric Abdominal Transplant, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.
BACKGROUND: Allospecific CD154+T-cytotoxic memory cells (CD154+TcM) are used clinically to predict acute cellular rejection (ACR) after intestine transplantation (ITx) in children <21 years old within…
2018 American Transplant Congress
A Population Based Study of Incidence of Post Kidney Transplant Malignancies
D. Sexton,¹ J. O'Neill,² P. O'Kelly,¹ S. Murray,¹ S. Deady,³ E. O'Leary,³ P. Morris,⁴ P. Conlon.¹
¹Department of Nephrology & Transplantation, Beaumont Hospital Dublin, Royal College of Surgeons Ireland, Dublin, Ireland; ²Department of Otolaryngology, Head and Neck Surgery, Beaumont Hospital, Dublin, Ireland; ³National Cancer Registry Ireland, Cork, Ireland; ⁴Department of Oncology, Beaumont Hospital, Dublin, Ireland.
IntroductionWe aimed to report national standardised incidence for malignancy post transplant compared to the general population stratified by solid organ categories. In this study we…
2018 American Transplant Congress
The Risk Factors of Acute Rejection in Patients with BK Nephropathy after the Reduction of Immunosuppression
C. Baek,¹ H. Kim,¹ W. Yang,¹ D. Han,² S-.K. Park.¹
¹Department of Internal Medicine, Division of Nephrology, Asan Medical Center, Seoul, Republic of Korea; ²Department of Surgery, Asan Medical Center, Seoul, Republic of Korea.
Background: BK nephropathy (BKN) affects graft function and increases the risk of graft failure. The reduction of immunosuppression is the main treatment for BKN. However,…
2018 American Transplant Congress
Elevated Levels of CD19⁺ B Cells before or after Rituximab Administration is a Risk Factor for the Early Rejection of a Living Kidney Transplant
M. Kono,¹ H. Shirakawa,² S. Wakai.¹
¹Nephrology, Ohkubo Hospital, Tokyo, Japan; ²Urology, Ohkubo Hospital, Tokyo, Japan.
[Introduction]Rituximab (RTX) is used for desensitization in highly sensitized patients, such as those undergoing ABO-incompatible (ABOi) kidney transplantation. Although RTX is generally effective, some patients…
2018 American Transplant Congress
Ideal Body Weight versus Actual Body Weight for Rabbit Antithymocyte Globulin Induction in Pancreas Transplantation
E. Martinez,¹ D. Felix,² J. Wiegel,² T. Al-Qaoud,¹ G. Leverson,¹ A. Condon,² R. Redfield,¹ J. Odorico.¹
¹Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI; ²Department of Pharmacy, UW Health, Madison, WI.
Purpose: Rabbit antithymocyte globulin (rATG) is the most commonly used induction agent in solid organ pancreas transplantation. The optimal induction dosing of rATG, has not…
2018 American Transplant Congress
Outcomes Associated with Rabbit Anti-Thymocyte Globulin Induction According to Mg/Kg of Total Body Weight in Kidney Transplant Recipients
A. Brueckner, A. Logan, L. Bowman.
Pharmacy, Tampa General Hospital, Tampa, FL.
Purpose: The optimal dosing weight used for rabbit anti-thymocyte globulin (rATG) induction therapy in transplantation continues to lack a consensus. The impact of alternative dosing…
2018 American Transplant Congress
The Impact of Rapamycin Conversion in Pediatric Liver Transplantation on Anti-HLA Antibody Formation and Allograft Fibrosis
R. Fischer,² L. Fromm,¹ J. Daniel,² A. Kats,² R. Hendrickson,² W. Andrews.²
¹University of Kansas College of Medicine, Kansas City, KS; ²Children's Mercy Hospital, Kansas City, MO.
Background: Maintenance immunosuppression with tacrolimus (TAC) is associated with progressive liver allograft fibrosis. Conversion to rapamycin (RAPA) may abrogate this progression. The development of donor-specific…