Articles tagged "Immunosuppression"

2018 American Transplant Congress
Impact of Single Nucleotide Polymorphisms on P450 Oxidoreductase and Peroxisome Proliferator-Activated Receptor alpha on Tacrolimus Pharmacokinetics in Renal Transplant Recipients
Z. Wang, Z. Han, J. Tao, H. Chen, S. Li, R. Tan, M. Gu.
Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
The P450 oxidoreductase (POR) and peroxisome proliferator-activated receptor alpha (PPARA) genes have been reported to be associated with the activity of cytochrome P450 enzymes in…
2018 American Transplant Congress
Tacrolimus Metabolism in Subjects with Potentially Absent CYP3A Activity
A. Scheibner,¹ R. Remmel,² D. Schladt,³ W. Oetting,¹ W. Guan,⁴ B. Wu,⁴ C. Door,⁵ A. Israni,⁵ P. Jacobson.¹
¹Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN; ²Medicinal Chemistry, University of Minnesota, Minneapolis, MN; ³Minneapolis Medical Research Foundation, Hennepin County Medical Center, Minneapolis, MN; ⁴Biostatistics, University of Minnesota, Minneapolis, MN; ⁵Department of Medicine, Hennepin County Medical Center, Minneapolis, MN.
Purpose: Tacrolimus (TAC) is a well-known cytochrome P450 (CYP) 3A4 and 3A5 substrate. Common single nucleotide polymorphisms (SNPs) in these genes are significantly related to…
2018 American Transplant Congress
Decreased Clinical Significance of Isoagglutinin Titer with the Current Desensitization Protocol in ABO-Incompatible Kidney Transplantation
C. Baek, H. Kim, W. Yang, D. Han, S-.K. Park.
Department of Internal Medicine, Division of Nephrology, Asan Medical Center, Seoul, Republic of Korea; Department of Surgery, Asan Medical Center, Seoul, Republic of Korea.
ABO-incompatible (ABOi) kidney transplantation (KT) has become a routine procedure with graft survival rates comparable to those of ABO-compatible KT. However, the clinical significance of…
2018 American Transplant Congress
Evolutive Analysis of a 20-Year Pancreas Transplant Program
M. Perosa,¹ J. Branez,¹ L. Mota,¹ H. Noujaim,¹ B. Zeballos,¹ L. Ianhez,¹ L. Alvim,¹ D. Machado,¹ C. Watanabe,¹ F. Sergi,¹ M. Paredes,¹ T. Genzini-Miranda,² A. Silvestre,³ G. Martinho,⁴ T. Genzini.¹
¹Abdominal Organ Transplantation, Leforte Hospital, Sao Paulo, Brazil; ²Medical School, PUC Sorocaba, Sorocaba, Sao Paulo, Brazil; ³Medical School, Sao Camilo, Sao Paulo, Brazil; ⁴Medical School, Ciências Médicas Santa Casa, Sao Paulo, Brazil.
There is a worldwide trend towards a reduction in the annual number of pancreas transplants (PT). In Brazil, only two centers have performed more than…
2018 American Transplant Congress
Immunosuppression and the Risk of Dementia among Older Kidney Transplant Recipients
M. McAdams DeMarco,¹ C. Haugen,¹ S. Bae,¹ K. Lentine,² D. Segev.¹
¹JHU, Baltimore; ²SLU, St. Louis.
Background: Older recipients have a high burden of dementia after kidney transplantation (KT). Factors contributing to post-KT dementia may include long-standing kidney disease, comorbid vascular…
2018 American Transplant Congress
Automated Systems to Identify and Address Adherence Barriers Result in Sustained Reduction of Late Allograft Rejection
D. Hooper, C. Varnell, Jr., K. Rich, J. Huber, D. Dahale, A. Carle, A. Pai, A. Modi.
Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Background: Patient-identified barriers to taking immunosuppressive medications are associated with rejection and allograft loss, yet interventions targeting adherence barriers are rarely integrated into clinical practice.…
2018 American Transplant Congress
Sirolimus-Based, Prednisone-Free Regimen in Kidney Transplantation: Long Term Results of an Open-Label, Randomized Controlled Trial
A. Shetty,¹ B. Ho,¹ V. Mas,² Y. Kassis,¹ S. Park,¹ J. Leventhal,¹ D. Chhabra,³ L. Gallon.¹
¹Northwestern University, Chicago; ²University of Virginia, Charlottesville; ³Advocate Christ Medical Center, Chicago.
Background: Calcineurin (CNI) nephrotoxicity is implicated in chronic allograft dysfunction and presents an argument for CNI minimizing immunosuppression. We assessed the long-term effects of CNI…
2018 American Transplant Congress
Efficacy and Safety of a Single-Dose Rituximab for Prevention of Focal Segmental Glomerulosclerosis Recurrence after Kidney Transplant
Y. Lu,¹ J. Lyons,² S. Tischer,² K. Woodside,³ J. Park.²
¹Transplant Nephrology, University of Michigan, Ann Arbor, MI; ²Transplant Pharmacy, University of Michigan, Ann Arbor, MI; ³Transplant Surgery, University of Michigan, Ann Arbor, MI.
Background: For patients with end stage renal disease (ESRD) due to primary focal segmental glomerulosclerosis (FSGS), there is a significantly increased risk for disease recurrence…
2018 American Transplant Congress
Mycophenolate Monotherapy is Safe and Effective in HLA-Matched Kidney Transplant Recipients
A. Hennes, K. Holdener, W. Burlingham, B. Astor, A. Djamali.
UW Health, Madison, WI.
Purpose: The ideal minimizing strategy for maintenance immunosuppression in HLA-matched kidney transplant recipients (KTR) is unknown. We hypothesized that mycophenolate (MPA) monotherapy is a safe…
2018 American Transplant Congress
Evaluation of Survival and Maintenance Immunosuppression in Elderly Lung Transplant Recipients
P. Nguyen,¹ R. Girgis,^1,2 E. Murphy,^1,2 R. Hadley,^1,2 M. Leacche,^1,2 A. Kumar,^1,2 G. Sathiyamoorthy,^1,2 J. McDermott.^1,2
¹Spectrum Health, Grand Rapids, MI; ²Michigan State University College of Human Medicine, Grand Rapids, MI.
Background: Lung transplantation in the elderly is controversial given increased risks and the optimal immunosuppression regimen is not fully understood.Methods: A retrospective cohort study was…