Articles tagged "Immunosuppression"

2019 American Transplant Congress
Impact of Induction Choice and Early Steroid Withdrawal on Outcomes in HLA Zero Mismatched Kidney Transplant Recipients
C. Votruba¹, K. Holdener¹, B. Astor², F. Aziz², D. Mandelbrot²
¹Pharmacy, University of Wisconsin Hospitals and Clinics, Madison, WI, ²Nephrology, University of Wisconsin Hospitals and Clinics, Madison, WI
*Purpose: Ideal induction and immunosuppression therapy for 6-antigen HLA matched deceased and living kidney transplant recipients (KTR) is not well understood.*Methods: All 6-antigen HLA matched…
2019 American Transplant Congress
Belatacept Conversion for Calcineurin Inhibitor-Associated Thrombotic Microangiopathy in Kidney Transplant Recipients
S. A. Muhsin, K. Safa, H. M. Gilligan, E. C. Heher, W. W. Williams, D. M. Wojciechowski
Nephrology Division, MGH, Boston, MA
*Purpose: Thrombotic Microangiopathy (TMA) in kidney transplant recipients is a serious complication that can cause graft loss. It can be associated with immunosuppressive medications such…
2019 American Transplant Congress
Immunobiogram, a New IVD Immunoassay to Test the Sensitivity Profile of Kidney Transplant Recipients to Immunosuppressive Drugs: Further Results from BH-Pilot Study
C. Jimenez¹, J. M. Portoles², D. Blánquez³, L. Arribas³, A. Ortega⁴, T. Diez⁵, I. Portero⁶
¹Nephrology Department, La Paz Hospital, Madrid, Spain, ²Nephrology Department, Puerta de Hierro Mahadahonda Hospital, Madrid, Spain, ³Adamas Engineering Consulting, Madrid, Spain, ⁴I+D, Biohope, Madrid, Spain, ⁵Medical, Biohope, Madrid, Spain, ⁶CEO, Biohope, Madrid, Spain
*Purpose: IMBG is an immunoassay developed by Biohope to measure in vitro PBMC sensitivity/resistance profile to a panel of immunosuppressive drugs (IS) in Kidney Transplant…
2019 American Transplant Congress
Risk Factors for Recurrent Urinary Tract Infections and Antimicrobial Resistant Organisms in Kidney Transplant Recipients
S. Greissman¹, A. Mattiazzi², J. Quinonez¹, M. Grady¹, R. Zukerman¹, A. Wawrzyniak³, M. Morris⁴, S. Anjan⁴, J. Simkins⁴, J. Camargo⁴, L. Abbo⁵
¹University of Miami Miller School of Medicine, Miami, FL, ²Department of Transplant Nephrology, University of Miami Miller School of Medicine, Miami, FL, ³Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, ⁴Department of Infectious Diseases, University of Miami Miller School of Medicine, Miami, FL, ⁵Department of Infection Control and Prevention and Antimicrobial Stewardship, University of Miami Miller School of Medicine, Miami, FL
*Purpose: Up to 20% of urinary tract infections (UTIs) in kidney transplant (KT) recipients are caused by multidrug-resistant organisms (MDROs). The risk factors for developing…
2019 American Transplant Congress
Comparison of Long-Term Outcomes between Alemtuzumab and Rabbit Anti-Thymocyte Globulin for Acute Kidney Allograft Rejection
M. van der Zwan, M. C. Clahsen-van Groningen, D. L. Roelen, M. W. van den Hoogen, M. Van Agteren, J. I. Roodnat, C. C. Baan, D. A. Hesselink
Erasmus MC, Rotterdam, Netherlands
*Purpose: T cell-depleting antibody therapy with rabbit anti-thymocyte globulin (rATG) is the treatment of choice for glucocorticoid-resistant, recurrent and/or severe acute kidney allograft rejection (AR).…
2019 American Transplant Congress
Induction Therapy Modulated by the Absence of Preformed Donor-Specific Antibodies (DSAS) Regardless of the Level of Sensitization
M. Cristelli, K. Linhares, R. de Marco, L. Viana, C. Felipe, M. Gaspar, C. Peixoto, G. Marcelo Gomes, J. Toniato Rezende, K. Nunes Ficher, L. Alfaro Villanueva, V. Lima, M. Gerbase de Lima, J. Medina Pestana, H. Tedesco Silva Junior
Núcleo de Ensino e Pesquisa, Hospital do Rim, São Paulo, Brazil
*Purpose: We hypothesized that sensitized patients with preformed DSAs other than anti-HLA A, B, DR could receive less intensive induction therapy.*Methods: Single center retrospective cohort…
2019 American Transplant Congress
Immunosuppressant Adherence in Adult Heart Transplant Recipients: An Analysis of Pharmacy Claims and Organ Procurement and Transplantation Network Data
W. S. Cherikh¹, A. R. Wilk¹, J. Maghirang¹, E. A. Witt², H. Kirkham³, S. Boghani², N. Hira⁴, G. Pietradoni², D. K. Klassen¹
¹United Network for Organ Sharing, Richmond, VA, ²Walgreens Co, Deerfield, IL, ³Walgreens Co, Deerfied, IL, ⁴AllianceRx Walgreens Prime, Orlando, FL
*Purpose: The current study was conducted to determine characteristics that are associated with immunosuppressant (IS) medication adherence among adult recipients of deceased donor heart transplants…
2019 American Transplant Congress
Dendritic Cells Transduced with Autoimmune Regulator Exhibit Immature Properties and Prolong Heart Allograft Survival
Y. Zhang, Z. Zhu, M. Chen, S. Huang, C. Sun, W. Ju, Z. Guo, X. He
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: The expression of the Aire (Autoimmune regulator) gene was observed to inhibit the maturation and activation of dendritic cells (DCs) and induce transplantation tolerance.*Methods:…
2019 American Transplant Congress
Polymorphisms in Mycophenolate Mofetil Glucuronidation Gene Are Associated with Leukopenia and Decreased CLAD-Free Survival
A. Barnes, D. R. Calabrese, E. Henricksen, R. Florez, K. Dewey, P. Wang, J. Teraoka, K. Lien, S. Hays, J. P. Singer, J. Golden, J. Kukreja, J. R. Greenland
UCSF Medical Center, San Francisco, CA
*Purpose: Lung transplant recipients vary in their tolerance of the immunosuppressant mycophenolate mofetil (MMF). Single nucleotide polymorphisms (SNPs) in UDP-glucuronosyltransferase 2B7 (UGT2B7) increase conversion of…
2019 American Transplant Congress
Hepatitis C Positive Donor to Negative Recipient Kidney Transplantation: A Single Center Real World Experience
N. Jandovitz, V. Nair, E. Grodstein, E. Molmenti, A. Fahmy, M. Bhaskaran, L. Teperman
North Shore University Hospital, Manhasset, NY
*Purpose: Several small studies have shown that transplanting a hepatitis C virus (HCV) negative recipient with a HCV positive donor is feasible in a research…