Articles tagged "Immunosuppression"

2019 American Transplant Congress
Desensitization Protocols vs Kidney Paired Donation to Overcome AB0 Incompatibility and/or Donor Specific Antibodies in Living Donor Kidney Transplantation
F. Vistoli, V. Perrone, L. Gozzini, E. Kauffmann, N. Napoli, S. Iacopi, C. Lombardo, G. Amorese, U. Boggi
Pancreas and Kidney Transplantation Center, University of Pisa, Pisa, Italy
*Purpose: International guidelines indicate Living Donor Kidney Transplantation (LDKT) as the best option for ESRD patients. Immunological barriers like AB0 incompatibility (AB0i) and donor specific…
2019 American Transplant Congress
Low Dose Thymoglobulin Has No Disadvantages to Standard Higher Dose: A Report of the Midwest Pediatric Nephrology Consortium
I. Ashoor¹, R. Beyl², C. Gupta³, A. Jain⁴, S. Kiessling⁵, H. Patel⁶, J. Sherbotie⁷, D. J. Weaver Jr⁸, R. Zahr⁹, V. Dharnidharka¹⁰
¹LSU Health, New Orleans, LA, ²Pennington Biomedical Research Center, Baton Rouge, LA, ³Children's National Medical Center, Washington, DC, ⁴Wayne State University, Detroit, MI, ⁵University of Kentucky, Lexington, KY, ⁶Nationwide Children's Hospital, Colombus, OH, ⁷University of Utah SOM, Salt Lake City, UT, ⁸Levine Children's Hospital, Charlotte, NC, ⁹University of Tennessee, Memphis, TN, ¹⁰Washington University, St. Louis, MO
*Purpose: What is not known is whether a lower Thymoglobulin (ATG) induction dose provides safe and effective immunosuppression compared to a “standard” higher dose in…
2019 American Transplant Congress
Fatal Graft versus Host Disease in Liver Transplantation. An Analysis of UNOS Registry
S. Nagai¹, A. Yoshida¹, R. Salgia², M. Abouljoud¹, D. Moonka²
¹Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI, ²Gastroenterology, Henry Ford Hospital, Detroit, MI
*Purpose: Graft-versus-host disease (GVHD) after liver transplant is a rare complication. This study aimed to analyze the UNOS registry to identify risk factors for fatal…
2019 American Transplant Congress
Immunosuppressant Adherence in Adult Liver Transplant Recipients in the United States
W. S. Cherikh¹, A. R. Wilk¹, J. Maghirang¹, E. A. Witt², H. Kirkham², S. Boghani², N. Hira³, G. Pietradoni², D. K. Klassen¹
¹United Network for Organ Sharing, Richmond, VA, ²Walgreen Co, Deerfield, IL, ³AllianceRx Walgreens Prime, Orlando, FL
*Purpose: We sought to determine the characteristics associated with immunosuppressant (IS) medication adherence among adult recipients of deceased donor liver transplants (TXs) in the US.*Methods:…
2019 American Transplant Congress
Mitochondrial Dysfunction and Metabolic Reprogramming: Critical Features of Cyclosporine A Nephrotoxicity
A. A. Zmijewska, G. Benavides, V. Darley-Usmar, J. W. Zmijewski, R. B. Mannon
University of Alabama at Birmingham, Birmingham, AL
*Purpose: Calcineurin inhibitors (CNIs) are potent immunosuppressants but over time contribute to allograft fibrosis. Clinical efforts to minimize or avoid CNI have not been uniformly…
2019 American Transplant Congress
Risk Factors for 1-5 Year Major Infection Events (MIE) after Kidney Transplant (KTx) Including First-Year Immunosuppression (IS) Data: An Analysis of the Choosing Immune Suppression in Renal Transplantation by Efficacy and Morbidity (CISTEM) Study
V. Dharnidharka¹, D. Axelrod², Z. Zhang³, M. Schnitzler³, K. Lentine³, B. Kasiske⁴
¹Washington Univ, St. Louis, MO, ²Univ of Iowa, Iowa City, IA, ³Saint Louis Univ, St. Louis, MO, ⁴SRTR, Minneapolis, MN
*Purpose: From our CISTEM study of linked national registries, we reported that older recipient age, female sex, diabetic kidney failure, non-standard-criteria organs, and mTORi-based IS…
2019 American Transplant Congress
MDSCs Prolong Allogeneic Cardiac Graft Survival by Regulating Interferon Type 1 Signaling
S. Cai¹, P. T. Sage¹, T. J. Borges¹, T. Ichimura¹, S. K. Eskandari¹, J. Y. Choi¹, I. Salkuj¹, B. S. AI Dulaijan¹, H. Allos¹, J. Miao², L. V. Riella¹, A. K. Chandraker¹, J. R. Azzi¹
¹Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Boston Children's Hospital, Harvard Medical School, Boston, MA
*Purpose: We previously demonstrated that donor-derived regulatory dendritic cells (DCreg), contrary to recipient derived DCreg, promote antigen-specific allograft protection. As myeloid-derived suppressor cells (MDSC) show…
2019 American Transplant Congress
Implementation of a De Novo Belatacept Protocol
D. Wojciechowski¹, M. Jacobs², K. Safa¹, H. Gilligan¹, H. Eliot¹, W. W. Williams, Jr¹
¹Massachusetts General Hospital, Boston, MA, ²Wake Forest, Winston-Salem, NC
*Purpose: The use of belatacept with basiliximab induction and maintenance MMF/prednisone when compared to cyclosporine is associated with superior long-term patient and graft survival but…
2019 American Transplant Congress
Belatacept Use in High Kidney Donor Profile Index Kidney Transplant Recipients
D. Britt¹, A. Gharabagi¹, K. Botkin¹, T. Horwedel², C. Carthon¹, J. Hagopian¹
¹Pharmacy, Barnes-Jewish Hospital, St. Louis, MO, ²Veloxis Pharmaceuticals, Cary, NC
*Purpose: To determine whether the use of belatacept is associated with renal function preservation in kidney transplant recipients from donors with a kidney donor profile…
2019 American Transplant Congress
ICOS⁺PD-1⁺ Circulating T Follicular Helper Cells Are a Biomarker of Humoral Alloreactivity and Predict Donor-Specific Antibody Generation Following Transplantation
G. M. La Muraglia II, M. E. Wagener, M. L. Ford, I. R. Badell
Emory Transplant Center, Atlanta, GA
*Purpose: Mounting evidence in kidney transplantation suggests that donor-specific antibodies (DSA) significantly contribute to renal allograft loss. However, biomarkers to guide clinical management of DSA…