Articles tagged "Immunosuppression"

2019 American Transplant Congress
Graft Perfusion with Alvespimycin, an HSP90 Inhibitor, Suppresses IL-2 and IL-12p40 Production in Graft-Infiltrating Cells, Leading to Prolongation of Graft Survival in Murine Heart Transplantation
T. Tanaka, T. Maehana, N. Masumori
Department of Urology, Sapporo Medical University, Sapporo, Japan
*Purpose: We have previously demonstrated that administration of a heat shock protein 90 (HSP90) inhibitor prolonged the allograft survival in murine skin and heart transplantations.…
2019 American Transplant Congress
Local IL-33 Regulates Heart Transplant Infiltrating Myeloid Cells Metabolism and Differentiation to Protect against Chronic Rejection
Z. Zhang¹, Q. Liu¹, T. Li¹, G. S. Hussey², M. Velayutham¹, J. L. Dziki², L. R. Mathews¹, Y. C. Lee², G. K. Dwyer¹, H. Dai¹, A. S. Roessing¹, S. Shiva³, M. H. Oberbarnscheidt¹, S. F. Badylak², H. R. Turnquist¹
¹Department of Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, ²Department of Bioengineering, McGowan Institute for Regenerative Medicine, Pittsburgh, PA, ³Department of Pharmacology and Chemical Biology, Vascular Medicine Institute, Pittsburgh, PA
*Purpose: Self-molecules containing damage-associated molecular patterns stimulate the pro-inflammatory response of infiltrating innate immune cells after their release during tissue injury. Yet, if local endogenous…
2019 American Transplant Congress
Psychosocial Factors and Medication Adherence among Recipients of Vascularized Composite Allografts
S. Rasmussen¹, M. Henderson¹, C. Cooney¹, J. Shores¹, W. Lee¹, E. Goldman², C. Kaufman², D. Segev¹, G. Brandacher¹
¹Johns Hopkins University, Baltimore, MD, ²Christine M Kleinert Institute, Louisville, KY
*Purpose: Psychosocial factors are important predictors of medication adherence, and subsequently graft survival, in solid organ transplantation. Early experiences suggest this may be the case…
2019 American Transplant Congress
Dosing and Exposure over 2 Years with LCP-Tacrolimus (LCPT) vs. Immediate-Release Tacrolimus (IR-Tac) in De Novo Kidney Transplantation
K. Budde¹, S. Bunnapradist², S. Patel³, D. Stevens³, U. Meier-Kriesche³, B. Suwelack⁴
¹Charité University Medicine Berlin, Berlin, Germany, ²UCLA Medical Center, Los Angeles, CA, ³Veloxis Pharmaceuticals Inc, Cary, NC, ⁴University Hospital of Münster, Münster, Germany
*Purpose: A prospective study demonstrated safe and efficacious use of LCPT in de novo kidney transplantation. This study aims to evaluate tacrolimus trough levels and…
2019 American Transplant Congress
Delayed Achievement of Therapeutic Tacrolimus Levels with De Novo Extended-Release Tacrolimus Tablets and the Incidence of Rejection in Kidney Transplant Patients
C. E. Carthon¹, J. C. Hagopian¹, S. E. January¹, A. Gharabagi¹, R. Delos Santos², T. A. Horwedel³
¹Pharmacy, Barnes-Jewish Hospital, Saint Louis, MO, ²Nephrology, Washington University School of Medicine, Saint Louis, MO, ³Veloxis Pharmaceuticals, Inc., Cary, NC
*Purpose: Early therapeutic tacrolimus levels have been associated with improved outcomes in renal transplant recipients while lower exposure to tacrolimus during the first week of…
2019 American Transplant Congress
Combined Pre-Transplant Anti-Donor T-Cell Sensitization with Single Nucleotid Polimorphisms (SNPs) for CYP3A4 Tacrolimus Metabolism Identifies Kidney Transplant Patients at High Risk of Allograft Rejection
E. Crespo¹, A. Vidal¹, A. Sefrin², P. Fontova¹, M. Stein², H. Volk², J. Grinyó³, P. Reinke², N. Lloberas¹, O. Bestard³
¹Experimental Nephrology Laboratory, IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain, ²Nephrology, Charité Campus Virchow-Klinikum, Berlin, Germany, ³Kidney Transplant Unit, Bellvitge University Hospital- IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain
*Purpose: Preformed donor-specific (d-sp) T-cell alloimmunity has been associated to high risk of acute rejection (BPAR). Since the individual susceptibility related to specific single nucleotide…
2019 American Transplant Congress
Bespoke Immunosuppression: Prolonging Transplant Survival through Enhanced T-cell Activation Induced Cell Death
R. Costello¹, R. J. Ingram¹, D. Longley², J. McDaid³
¹WWIEM, QUB, Belfast, United Kingdom, ²CCRCB, QUB, Belfast, United Kingdom, ³Renal Transplantation, Belfast City Hospital, Belfast, United Kingdom
*Purpose: We aim to develop donor-specific immunosuppression by inhibiting T-cell cellular FLICE like inhibitory protein (c-FLIP). Our current work focuses on clinically relevant pharmacological inhibitors…
2019 American Transplant Congress
Immunosuppression Reduction after Diagnosis of Sustained BK Viremia and the Risk of Allograft Rejection, Allograft Loss and Mortality
F. A. Al Dhufairi¹, M. Shokoohi², A. M. Jevnikar¹, A. A. House¹, D. Kumar³, S. M. Hosseini-Moghaddam¹
¹Department of Medicine, Western University, London Health Sciences Centre, London, ON, Canada, ²Epidemiology and Biostatistics, Western University, London, ON, Canada, ³Department of Medicine, University Of Toronto, University Health Network, Toronto, ON, Canada
*Purpose: BK viremia increases the risk of allograft loss after renal transplantation. Current guidelines recommend immunosuppression reduction (IsR) after the diagnosis of BK viremia. The…
2019 American Transplant Congress
Leukopenia at the Time of Liver Transplantation: Medication Tolerance and Clinical Outcomes
E. Tiao¹, J. Casale¹, J. LaMattina², S. Hammad¹
¹Pharmacy, University of Maryland Medical Center, Baltimore, MD, ²Surgery, University of Maryland School of Medicine, Baltimore, MD
*Purpose: Leukopenia post-orthotopic liver transplant (OLT) is associated with an increased incidence of infection and mortality. Prior to OLT, leukopenia may suggest innate immunosuppression and…
2019 American Transplant Congress
Characteristics Associated with Immunosuppressant Adherence after Deceased Donor Kidney Transplant
A. R. Wilk¹, W. S. Cherikh¹, J. Maghirang¹, E. A. Witt², H. Kirkham², S. Boghani², N. Hira³, G. Pietradoni², D. K. Klassen¹
¹United Network for Organ Sharing, Richmond, VA, ²Walgreen Co, Deerfield, IL, ³AllianceRx Walgreens Prime, Orlando, FL
*Purpose: Without adherence to immunosuppressant (IS) medication, renal allografts will likely not last in transplant (TX) recipients, which may result in progressively worsened renal function…