Articles tagged "Immunosuppression"

2019 American Transplant Congress
Patient-Reported Outcomes in a Prospective Multicenter Trial of Belatacept-Based CNI- and Corticosteroid-Free Immunosuppression Regimens in Kidney Transplantation
J. M. Rohan¹, J. P. Leone², E. S. Woodle³, D. Kaufman⁴, A. R. Shields³, A. Wiseman⁵, A. J. Matas⁶, P. West-Thielke⁷, E. King³, R. R. Alloway³
¹Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, VA, ²Tampa General Hospital, Tampa, FL, ³University of Cincinnati College of Medicine, Cincinnati, OH, ⁴University of Wisconsin – Madison, Madison, WI, ⁵University of Colorado - Denver, Denver, CO, ⁶University of Minnesota Medical Center, Minneapolis, MN, ⁷University of Illinois – Chicago, Chicago, IL
*Purpose: Previous trials have not examined differences in patient-reported outcomes (PRO) between belatacept (BELA)- and tacrolimus (TAC)-based therapies in adult kidney transplant (KTx) patients (pts).…
2019 American Transplant Congress
Tacrolimus Pharmacokinetics in Young, Middle Age and Older Renal Transplant Recipients- Impact of CYP3A5*3*6*7 Metabolic Composite
K. Tornatore¹, K. Attwood², D. Brazeau³, R. Venuto⁴
¹University at Buffalo; School of Pharmacy, Buffalo, NY, ²Biostatistics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, ³Marshall University; School of Medicine, Huntington, WV, ⁴University at Buffalo; School of Medicine, Buffalo, NY
*Purpose: In spite of increased renal transplantation in patients over 60 years and the need for age-adjusted tacrolimus maintenance immunosuppression, limited pharmacokinetic comparisons between young,…
2019 American Transplant Congress
Selective CD28 Blockade-Mediated Inhibition of T Follicular Helper Cell and DSA Responses is CTLA-4 Dependent
G. M. La Muraglia II, M. L. Ford, I. R. Badell
Emory Transplant Center, Atlanta, GA
*Purpose: Clinical costimulation blockade of the CD28 pathway in the form of CTLA-4Ig has shown the ability to attenuate T cell dependent DSA responses. However,…
2019 American Transplant Congress
Impact of Induction Choice and Early Steroid Withdrawal on Outcomes in HLA Zero Mismatched Kidney Transplant Recipients
C. Votruba¹, K. Holdener¹, B. Astor², F. Aziz², D. Mandelbrot²
¹Pharmacy, University of Wisconsin Hospitals and Clinics, Madison, WI, ²Nephrology, University of Wisconsin Hospitals and Clinics, Madison, WI
*Purpose: Ideal induction and immunosuppression therapy for 6-antigen HLA matched deceased and living kidney transplant recipients (KTR) is not well understood.*Methods: All 6-antigen HLA matched…
2019 American Transplant Congress
Belatacept Conversion for Calcineurin Inhibitor-Associated Thrombotic Microangiopathy in Kidney Transplant Recipients
S. A. Muhsin, K. Safa, H. M. Gilligan, E. C. Heher, W. W. Williams, D. M. Wojciechowski
Nephrology Division, MGH, Boston, MA
*Purpose: Thrombotic Microangiopathy (TMA) in kidney transplant recipients is a serious complication that can cause graft loss. It can be associated with immunosuppressive medications such…
2019 American Transplant Congress
Immunobiogram, a New IVD Immunoassay to Test the Sensitivity Profile of Kidney Transplant Recipients to Immunosuppressive Drugs: Further Results from BH-Pilot Study
C. Jimenez¹, J. M. Portoles², D. Blánquez³, L. Arribas³, A. Ortega⁴, T. Diez⁵, I. Portero⁶
¹Nephrology Department, La Paz Hospital, Madrid, Spain, ²Nephrology Department, Puerta de Hierro Mahadahonda Hospital, Madrid, Spain, ³Adamas Engineering Consulting, Madrid, Spain, ⁴I+D, Biohope, Madrid, Spain, ⁵Medical, Biohope, Madrid, Spain, ⁶CEO, Biohope, Madrid, Spain
*Purpose: IMBG is an immunoassay developed by Biohope to measure in vitro PBMC sensitivity/resistance profile to a panel of immunosuppressive drugs (IS) in Kidney Transplant…
2019 American Transplant Congress
Risk Factors for Recurrent Urinary Tract Infections and Antimicrobial Resistant Organisms in Kidney Transplant Recipients
S. Greissman¹, A. Mattiazzi², J. Quinonez¹, M. Grady¹, R. Zukerman¹, A. Wawrzyniak³, M. Morris⁴, S. Anjan⁴, J. Simkins⁴, J. Camargo⁴, L. Abbo⁵
¹University of Miami Miller School of Medicine, Miami, FL, ²Department of Transplant Nephrology, University of Miami Miller School of Medicine, Miami, FL, ³Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, ⁴Department of Infectious Diseases, University of Miami Miller School of Medicine, Miami, FL, ⁵Department of Infection Control and Prevention and Antimicrobial Stewardship, University of Miami Miller School of Medicine, Miami, FL
*Purpose: Up to 20% of urinary tract infections (UTIs) in kidney transplant (KT) recipients are caused by multidrug-resistant organisms (MDROs). The risk factors for developing…
2019 American Transplant Congress
Comparison of Long-Term Outcomes between Alemtuzumab and Rabbit Anti-Thymocyte Globulin for Acute Kidney Allograft Rejection
M. van der Zwan, M. C. Clahsen-van Groningen, D. L. Roelen, M. W. van den Hoogen, M. Van Agteren, J. I. Roodnat, C. C. Baan, D. A. Hesselink
Erasmus MC, Rotterdam, Netherlands
*Purpose: T cell-depleting antibody therapy with rabbit anti-thymocyte globulin (rATG) is the treatment of choice for glucocorticoid-resistant, recurrent and/or severe acute kidney allograft rejection (AR).…
2019 American Transplant Congress
Induction Therapy Modulated by the Absence of Preformed Donor-Specific Antibodies (DSAS) Regardless of the Level of Sensitization
M. Cristelli, K. Linhares, R. de Marco, L. Viana, C. Felipe, M. Gaspar, C. Peixoto, G. Marcelo Gomes, J. Toniato Rezende, K. Nunes Ficher, L. Alfaro Villanueva, V. Lima, M. Gerbase de Lima, J. Medina Pestana, H. Tedesco Silva Junior
Núcleo de Ensino e Pesquisa, Hospital do Rim, São Paulo, Brazil
*Purpose: We hypothesized that sensitized patients with preformed DSAs other than anti-HLA A, B, DR could receive less intensive induction therapy.*Methods: Single center retrospective cohort…
2019 American Transplant Congress
Immunosuppressant Adherence in Adult Heart Transplant Recipients: An Analysis of Pharmacy Claims and Organ Procurement and Transplantation Network Data
W. S. Cherikh¹, A. R. Wilk¹, J. Maghirang¹, E. A. Witt², H. Kirkham³, S. Boghani², N. Hira⁴, G. Pietradoni², D. K. Klassen¹
¹United Network for Organ Sharing, Richmond, VA, ²Walgreens Co, Deerfield, IL, ³Walgreens Co, Deerfied, IL, ⁴AllianceRx Walgreens Prime, Orlando, FL
*Purpose: The current study was conducted to determine characteristics that are associated with immunosuppressant (IS) medication adherence among adult recipients of deceased donor heart transplants…