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American Transplant Congress abstracts

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Articles tagged "Immunosuppression"

  • 2019 American Transplant Congress

    The Evolving Clinical Presentation of Acute Rejection in Face Transplantation

    V. Haug, B. Kollar, D. Obed, H. Kiwanuka, M. Turk, L. Wo, S. Tasigiorgos, M. Kueckelhaus, L. Riella, B. Pomahac

    Plastic and Reconstructive Surgery, Brigham and Women's Hospital, Boston, MA

    *Purpose: Clinical signs such as erythema or edema are traditionally helpful to diagnose Acute rejection (AR) in face transplantation (FT) in the early follow-up. The…
  • 2019 American Transplant Congress

    Tacrolimus Concentrations Can Be Reliably Measured in Capillary Microsamples

    M. T. Gustavsen, N. Vethe, M. Lauritsen, A. Andersen, A. Åsberg, S. Bergan, K. Midtvedt

    Oslo University Hospital, Rikshospitalet, Oslo, Norway

    *Purpose: Routine therapeutic drug monitoring (TDM) of tacrolimus (Tac) is currently performed in venous bloods samples drawn at the hospital. The novel volumetric absorptive microsampling…
  • 2019 American Transplant Congress

    Immunosuppression after Organ Transplantation Does Not Enhance Patency of Cold-Stored Vein Allografts for Critical Limb Ischemia -Single Centre Experience

    J. Chlupac, T. Marada, R. Novotny, K. Lipar, L. Janousek, J. Fronek

    Transplant Surgery Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

    *Purpose: Sub-inguinal bypass with cold-stored saphenous vein allograft is a last option treatment for extensive peripheral arterial occlusive disease with absent autologous vein. The aim…
  • 2019 American Transplant Congress

    Effect of Everolimus on IgM and IgG Memory B Cell Growth and Survival In Vitro and Applications for Effective Administration in Clinical Practice

    Y. Matsuda

    Osaka University Graduate School of Medicine, Osaka, Japan

    *Purpose: Everolimus (EVR), which is converted from CNI, is reported to improve renal function and reduce renal toxicity, DSA production, and rejection development. However, there…
  • 2019 American Transplant Congress

    Relationship between Comorbilities and Infectious Disease in Kidney Transplant Recipients Receiving Rituximab

    A. Molina-Andújar1, E. Hermida1, J. Rovira2, F. Cofan1, P. Ventura-Aguiar1, N. Esforzado1, V. Torregrosa1, D. Cucchiari1, E. de Souza1, I. Revuelta1, F. Oppenheimer1, F. Diekmann1, G. Piñeiro1

    1Renal Transplant Unit, Hospital Clínic de Barcelona, Barcelona, Spain, 2Laboratori Experimental de Nefrologia i Trasplantament, IDIBAPS, Barcelona, Spain

    *Purpose: Rituximab is commonly used in the context of kidney transplantation. Evidence about infectious complications and its relationship with predictive factors is scarce. The aim…
  • 2019 American Transplant Congress

    Blood Group Incompatible Living Donor Kidney Transplantation in Patients with End-Stage Kidney Disease Due to Diabetes Kidney Disease

    J. Uchida1, A. Kosoku1, K. Kabei1, S. Nishide1, H. Shimada1, K. Maeda2, Y. Yoshikawa3, T. Iwai1, N. Kuwabara1, T. Naganuma1, N. Kumada4, Y. Takemoto1, T. Nakatani1

    1Urology, Osaka City University Graduate School of Medicine, Osaka, Japan, 2Nursing, Osaka City University Hospital, Osaka, Japan, 3Osaka City University, Osaka, Japan, 4Urology, Suita Municipal Hospital, Suita, Japan

    *Purpose: Diabetes is a growing public health problem, and diabetes kidney disease (DKD) is the most prevalent chronic kidney disease and the major cause of…
  • 2019 American Transplant Congress

    Neutralization of Interlukin-6 by ALD518-P18 (Murine Clazakizumab) Attenuates Donor Specific Antibody Responses in a Mouse Model of Allogeneic Sensitization: A Report of Dosage Finding Study

    I. Kim, G. Wu, N. Chai, T. Brennan, A. Klein, S. Jordan

    Cedars-Sinai Med Ctr, Los Angeles, CA

    *Purpose: Interleukin-6 (IL-6) is a proinflammatory cytokine involved in mediating both T-cell and B-cell responses in allograft rejection. In previous studies, we demonstrated that inhibition…
  • 2019 American Transplant Congress

    Early Diagnosis of BK Virus Nephropathy Can Retrieve Kidney Allografts by Simple Reduction in Immunosuppressive Agents

    N. Iwahara, D. Iwami, K. Hotta, H. Okada, N. Shinohara

    Hokkaido Univercity, Sapporo, Japan

    *Purpose: Although BK virus nephropathy (BKVN) is a major complication after kidney transplant leading to graft loss, it is often difficult to diagnose and treat.…
  • 2019 American Transplant Congress

    The Immunomodulatory Role of Type I Interferons in Alloimmunity

    I. Sulkaj, H. Allos, S. K. Eskandari, J. M. Safadi, J. Y. Choi, B. S. Al Dulaijan, E. Al-Hussain, S. Cai, J. R. Azzi

    Medicine, Brigham and Women's Hospital, Boston, MA

    *Purpose: Despite a growing body of work on type 1 interferon (IFNAR1) signaling, there is a lack of consensus on the immunological properties of type…
  • 2019 American Transplant Congress

    Genome-Wide Profiling of BK Polyomavirus Integration in Urothelial Carcinoma of Kidney Transplant Recipients Reveals a Potential Microhomology or Nonhomologous End Joining Mediated Integration Mechanism

    Y. Jin1, Y. Zhou1, W. Deng1, R. Lee2, Y. Liu1, M. Blute3, R. Liu1, N. Elias4, F. Fu1, B. Guan1, J. Geng1, J. Ma5, J. Zhou5, N. Liu5, C. Wu6, Y. Miao1

    1Nanfang Hospital, Southern Medical University, Guangdzhou, China, 2Departments of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 3Departments of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 4Departments of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 5Mygenostics Co., Beijing, China, 6Departments of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA

    *Purpose: Chronic BK polyomavirus (BKV) infection is recognized as a potential oncogenic factor of urothelial carcinoma (UC) in renal transplant recipients. Besides, a positive correlation…
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