ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Immunosuppression"

  • 2019 American Transplant Congress

    Improving Medication Adherence and Outcomes in Adult Kidney Transplant Patients Using SystemCHANGETM: Results of the Medication Adherence Given Individual Change (MAGIC) Randomized Clinical Trial

    M. R. Wakefield1, C. M. Ashbaugh2, L. Remy3, D. Aholt3, C. Miller3, S. Ye3, D. K. Hathaway4, D. Clark4, V. S. Staggs5, K. Goggin6, R. J. Ellis7, C. L. Russell3

    1Surgery/Urology, University of Missouri School of Medicine, Columbia, MO, 2Transplant, University of Missouri Health Care, Columbia, MO, 3School of Nursing and Health Studies, University of Missouri-Kansas City, Kansas City, MO, 4College of Nursing, University of Tennessee HSC, Memphis, TN, 5Health Services and Outcomes Research, Children's Mercy Kansas City, Kansas City, MO, 6Health Services and Outcomes Research, Children's Mercy Kansas City and Schools of Medicine and Pharmacy, University of Missouri-Kansas City, Kansas City, MO, 7School of Nursing, Indiana University, Indianapolis, IN

    *Purpose: Medication non-adherence is an obdurate problem associated with poor outcomes and staggering costs. Even with multi-faceted interventions, effect sizes reported in meta-analyses of medication…
  • 2019 American Transplant Congress

    Beta2-Adrenergic Receptor Activation Prolongs Survival of Vascularized Composite Tissue Allotransplants in a Murine Model

    M. Kim1, D. Fisher1, J. Loo1, P. Bogner2, U. Sharma3, J. Skitzki1, E. Repasky4

    1Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 2Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 3Cardiology, University at Buffalo, Buffalo, NY, 4Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY

    *Purpose: Transplantation of faces, hands, and limbs using vascularized composite allotransplantation (VCA) has faced significant challenges hindering its routine implementation in the clinic. One critical…
  • 2019 American Transplant Congress

    Conversion from Tacrolimus Immediate Release to Tacrolimus Extended Release (Envarsus XR®): A Real World Cohort Highlighting Dosing Variability among Patients

    K. D. Belfield1, D. Malhotra2, M. Waleed3, E. A. Cohen1

    1Department of Pharmacy, Yale New Haven Hospital, New Haven, CT, 2Yale University School of Medicine, New Haven, CT, 3University of Connecticut School of Pharmacy, Storrs, CT

    *Purpose: Tacrolimus extended release (TacER) (Envarsus XR®) has become an attractive alternative to tacrolimus immediate release (TacIR) due to its once daily dosing scheme, favorable…
  • 2019 American Transplant Congress

    Adverse Effect Differences between Tacrolimus-IR and LCP-Tacrolimus

    J. Hagopian1, C. Carthon1, S. January1, A. Gharabagi2, R. Delos Santos3, T. Horwedel4

    1Barnes-Jewish Hospital, Saint Louis, MO, 2St. Louis College of Pharmacy, Saint Louis, MO, 3Washington Universidy, Saint Louis, MO, 4Veloxis Pharmaceuticals, Inc, Cary, NC

    *Purpose: Extended-release tacrolimus (Envarsus XR®, LCP-Tac) was approved in 2015 as conversion from tacrolimus immediate-release (Tac-IR) as part of the maintenance immunosuppression regiment post-kidney transplant.…
  • 2019 American Transplant Congress

    Costs Associated with A2 to B Kidney Transplantation: A Barrier to Its Utilization?

    R. Forbes, B. Concepcion, D. Shaffer

    Vanderbilt University Medical Center, Nashville, TN

    *Purpose: In 2014 the updated Kidney Allocation System (KAS) allowed for allocation of blood type A2 kidneys to B recipients in an effort to ameliorate…
  • 2019 American Transplant Congress

    Store-Operated/Calcium Release Activated Calcium Channel Orai3 is a Novel Target for Immunoregulation

    D. Shankaranarayanan1, M. Lagman1, V. Sharma1, C. Li1, M. Cassidy1, C. Snopkowski1, H. Yang1, T. Muthukumar1, K. Machaca2, M. Suthanthiran1

    1WCMC, New York, NY, 2WCMC, Doha, Qatar

    *Purpose: Store-operated/calcium release activated calcium (CRAC) channels are essential for the signaling of immune cells via calcineurin, a calcium-calmodulin dependent serine-threonine phosphatase. The central importance…
  • 2019 American Transplant Congress

    Cidofovir for BK Nephropathy Rescue Treatment: A Single Center Experience

    J. Slatinska1, E. Honsova2, T. Rohal1, A. Slavcev3, P. Hruba4, O. Viklicky1

    1Nephrology, IKEM, Prague, Czech Republic, 2Pathology, IKEM, Prague, Czech Republic, 3Immunology, IKEM, Prague, Czech Republic, 4Transplant Laboratory, IKEM, Prague, Czech Republic

    *Purpose: Cidofovir is a potentially nephrotoxic antiviral drug used primarily as a treatment for CMV retinitis however due to its potent antiviral effects has been…
  • 2019 American Transplant Congress

    Anti-CD272 Antibody (6B2) Induced Indefinite Survival of Fully MHC-Mismatched Murine Cardiac Allograft

    E. Yin, M. Uchiyama, Y. Yamamoto, M. Niimi

    Teikyo University, Tokyo, Japan

    *Purpose: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA; CD272) has been implicated in the regulation of autoimmune and may potentially play an important…
  • 2019 American Transplant Congress

    The Impact of Acute Rejection in Heart Transplantation on Post-Transplant Malignancy

    K. Kamrani1, A. Okoh2, D. Hanos1, M. Camacho1, M. Zucker2, K. Clarke1

    1Dept. of Surgery, Newark Beth Israel Medical Center, Newark, NJ, 2Dept. of Medicine, Newark Beth Israel Medical Center, Newark, NJ

    *Purpose: Compared with the general population, an increased incidence of skin cancers and lymphomas have been shown in orthotopic heart transplant (OHT) recipients. However, the…
  • 2019 American Transplant Congress

    Frailty Associated with Increased Rates of Acute Cellular Rejection within 3 Months after Liver Transplantation

    L. Fozouni, A. Lebsack, Y. Mohamad, C. Freise, P. Stock, J. Lai

    UCSF, San Francisco, CA

    *Purpose: Frailty, a state of decreased physiologic reserve and increased vulnerability to health stressors, has an inflammatory biologic basis and has been associated with dysregulation…
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