Articles tagged "Immunosuppression"

2020 American Transplant Congress
Effect of Maintaining Immunosuppression after Kidney Graft Failure on Mortality and Re-Transplantation
C. Schinstock, S. Balakrishnan, A. Bentall, M. Merzkani, M. Stegall
Mayo Clinic, Rochester, MN
*Purpose: Patients with a failed renal allograft are at high risk for mortality. The potential benefit of maintaining immunosuppression with the intent to minimize sensitization…
2020 American Transplant Congress
Unexpected Regulation of Foxp3+ Treg Production, Stability and Function by the Nuclear Co-Repressor, Sin3A
L. M. Christensen¹, T. Akimova², R. Han¹, L. Wang¹, A. Samanta¹, W. W. Hancock²
¹Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, ²Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA
*Purpose: Foxp3+ T-regulatory (Treg) cells are crucial to immune homeostasis and self-tolerance, but the contributions to Tregs of the 4 large, multiprotein nuclear complexes (Sin3,…
2020 American Transplant Congress
Adult Primary Liver Transplant Recipient Outcomes by Immunosuppression Induction Received
T. Shaker¹, G. Larrieux¹, S. Jackson², S. Riad³, T. Pruett¹, T. Leventhal⁴
¹Surgery, Division of Transplantation, University of Minnesota, Minneapolis, MN, ²M Health Fairview, Minneapolis, MN, ³Division of Renal Diseases and Hypertension, University of Minnesota, Minneapolis, MN, ⁴Division of Gastroenterology, Hepatology, and Nutrition, University of Minnesota, Minneapolis, MN
*Purpose: It has long been recognized that the highest risk of rejection of an organ is in the first few months post transplantation. To prevent…
2020 American Transplant Congress
Transplant Relevant MDSC Genetics: Differential Gene Expression Profiles of Immunosuppressive Myeloid-Derived Suppressor Cells Induced by Granulocyte-Colony Stimulating Factor
Y. S. Lee, J. S. Bromberg, J. R. Scalea
Department of Surgery, University of Maryland, Baltimore, MD
*Purpose: Myeloid-derived suppressor cells (MDSC) are expanded in inflammation conditions and can control alloreactive T cell responses. Granulocyte-colony stimulating factor (GCSF) is known to induce…
2020 American Transplant Congress
Impact of Donor Race on Tacrolimus Dose Requirement for Liver Transplant Recipients
N. Nesselhauf¹, S. January¹, J. Hagopian¹, K. Progar¹, A. Khan²
¹Pharmacy, Barnes-Jewish Hospital, St. Louis, MO, ²Surgery, Washington University School of Medicine, St. Louis, MO
*Purpose: It is well described that there is interpatient variability in tacrolimus dose requirements among transplant recipients. CYP3A5 plays a role in this variability. Black…
2020 American Transplant Congress
Impact of Immunosuppression on Quality of Life among HLA-Identical Living Kidney Recipients at UCLA – A Qualitative Study
E. L. Wood¹, S. George², N. Kogut¹, E. Lum, MD³, J. L. Veale¹
¹Urology, UCLA, Los Angeles, CA, ²Fielding School of Public Health, UCLA, Los Angeles, CA, ³Medicine, Nephrology, UCLA, Los Angeles, CA
*Purpose: Tolerant kidney transplant recipients (off immunosuppression) report higher self-rated quality of life and a lower symptom burden compared to standard living recipients when using…
2020 American Transplant Congress
The Safety and Efficacy of 6-Month Steroid Reduction Strategy after Kidney Transplantation: A Prospective Cohort Study
J. Bang, C. Oh, S. Lee
Department of Surgery, Ajou University Medical School, Suwon, Korea, Republic of
*Purpose: In kidney transplantation, immunosuppressive regimens almost always contain corticosteroids for preventing acute rejection and graft loss. However, long-term maintenance of corticosteroids has been associated…
2020 American Transplant Congress
Early Tacrolimus-LCP Conversion Due to Adverse Effects in Pancreas Transplant Recipients Improves Tolerance But Not Graft Survival
J. L. Descourouez, M. R. Jorgenson, D. C. Felix, J. Wiegel, G. E. Leverson, D. A. Mandelbrot, R. R. Redfield, J. S. Odorico
UW Health, Madison, WI
*Purpose: Tacrolimus-LCP (LCPT) is an extended release formulation of tacrolimus which has been shown to have fewer adverse drug effects (ADE) than immediate release tacrolimus…
2020 American Transplant Congress
CMV, EBV and BKV Viremia Rate Varied Depending on the Timing of Conversion to Belatacept (BLT)- from Calcineurin Inhibitor (CNI)-Based Immunosuppression and HLA-Sensitization (HS) Status in Kidney Transplant Patients (KTx Pts)
B. Shin, N. Ammerman, A. Vo, S. C. Jordan, M. Toyoda, S. Sethi
Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: Viral infections (VI) represent significant morbidity and mortality factors for KTx Pts. We previously showed more VI in BLT-treated Pts compared with CNI Pts…
2020 American Transplant Congress
Filgrastim Utilization Evaluation in Solid Organ Transplant Recipients
O. Witkowsky, L. Stanz, K. Schnelle
The Ohio State University Wexner Medical Center, Columbus, OH
*Purpose: Neutropenia occurs in up to 40% of kidney and liver transplant (txp) recipients and has been associated with higher mortality rates in liver txp.…