Articles tagged "Immunosuppression"

2020 American Transplant Congress
Implementation of a Pharmacist in an Adult Transplant Outpatient Clinic (Kidney, Liver, Pancreas): A Pilot Study – Implant
P. Leveille-Dugas¹, C. Bernard¹, L. Loiselle¹, Y. Zhang¹, C. Coursol¹, K. Mousseau¹, N. Sheehan¹, M. Cantarovich²
¹Pharmacy, McGill University Health Centre, Montréal, QC, Canada, ²Division of Nephrology, Department of Medicine, McGill University Health Centre, Montréal, QC, Canada
*Purpose: Solid organ transplant (SOT) patients require a complex medication regimen which increases the risk of many drug-related problems. The purpose of this study was…
2020 American Transplant Congress
Impact of Immunosuppression Protocol on the Incidence of EBV Viremia and PTLD in Pediatric Kidney Transplant Recipients: A Single Center Experience
K. Bowers¹, V. M. Panzarino¹, A. Campos¹, J. Buggs², V. D. Bowers²
¹Pediatrics, USF, Tampa, FL, ²Transplant Surgery, TGH, Tampa, FL
*Purpose: The purpose of this study was to evaluate the efficacy of an immunosuppression protocol change, which included avoidance of anti-thymocyte globulin for induction and…
2020 American Transplant Congress
Improved Kidney Function Post Lung Transplant with Intravenous Tacrolimus Avoidance
C. Burt¹, A. Feist¹, K. Afshar², L. Awdishu¹, M. Mariski¹, J. Kozuch¹, G. Yung², E. Golts³
¹Pharmacy, UC San Diego Health, San Diego, CA, ²Pulmonology, UC San Diego Health, San Diego, CA, ³Cardiothoracic Surgery, UC San Diego Health, San Diego, CA
*Purpose: Tacrolimus (TAC) poses a dose-dependent risk of acute kidney injury (AKI) as well as chronic kidney disease (CKD) post-transplant. In 2017, our institution’s lung…
2020 American Transplant Congress
Risk Factors for the Development of Avascular Necrosis: Single Center Experience
A. Karakok¹, A. Velioglu², I. H. Arikan², E. Asicioğlu², S. Tuglular¹
¹Marmara University School of Medicine, Istanbul, Turkey, ²Nephrology, Marmara University School of Medicine, Istanbul, Turkey
*Purpose: Avascular necrosis (AVN) is one of the most common bone complications after kidney transplantation. In recent years, it has become an important morbidity with…
2020 American Transplant Congress
A Novel Injectable Hydrogel-Based Approach to Localize and Tune the Actuation of Enhanced Costimulation Blockade to the Strength of Transplant Rejection
A. Komin¹, C. Liang², P. Majumder², X. Calderon-Colon³, O. Tiburzi³, M. Iglesias Lozano¹, Y. Zhang¹, G. Brandacher¹, J. Patrone³, J. Schneider², G. Raimondi¹
¹Johns Hopkins School of Medicine, Baltimore, MD, ²NIH National Cancer Institute, Frederick, MD, ³JHU Applied Physics Laboratory, Laurel, MD
*Purpose: Complications from long-term use of calcineurin inhibitors remain a major issue for transplant patients and alternative therapies are needed. The clinical efficacy of CTLA4-Ig…
2020 American Transplant Congress
Tolerant Liver Transplant Patients Have Higher Level of Y RNA Fragments in the Circulation
C. Kuscu¹, A. Wolen¹, A. Bajwa¹, C. Kuscu¹, J. Eason², B. Ramaswami³, D. Maluf¹, G. Mazariegos³, G. Chalasani³, V. Mas¹
¹Transplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, ²James D. Eason Transplant Institute, Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, ³Thomas E. Starzl Transplantation Institute, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: Tolerance post transplantation continue to be the ultimate goal in transplantation. Circulating small RNAs are one of the best candidates for biomarker studies. To…
2020 American Transplant Congress
TRANSBIO Study: Clinical Evaluation of Immunobiogram, a Novel In Vitro Diagnostic Immunoassay to Guide Adjustment of Immunosuppressive Therapy in Kidney Transplantation
J. Pascual¹, C. Jiménez², M. Krajewska³, C. Kotton⁴, D. Seron⁵, J. Portolés⁶, O. Witzke⁷, S. S. Sorensen⁸, A. Andrés⁹, T. Díez¹⁰, A. Ortega¹⁰, I. Portero¹⁰
¹Consorci Mar Parc de Salut, Barcelona, Spain, ²La Paz Hospital, Madrid, Spain, ³Wroclaw Medical University, Wroclaw, Poland, ⁴Massachusetts General Hospital, Boston, MA, ⁵Vall d’Hebron Hospital, Barcelona, Spain, ⁶Puerta de Hierro Mahadahonda Hospital, Madrid, Spain, ⁷University Hospital Essen, University Duisburg-Essen, Essen, Germany, ⁸Rigshospitalet, Copenhagen, Denmark, ⁹12 de Octubre Hospital, Madrid, Spain, ¹⁰Biohope Scientific Solutions for Human Health SL, Madrid, Spain
*Purpose: Immunobiogram (IMBG) is a first-in-class blood-based pharmacodynamic immunoassay that provides the sensitivity/resistance profile of each patient’s lymphocytes to a panel of immunosuppressive drugs (IS).…
2020 American Transplant Congress
Impact on Graft Histology of Steroid Withdrawal versus Standard Immunosuppression: Randomized, Parallel Group, Controlled Clinical Trial in Low Immunological Risk Kidney Transplant Patients
E. Gutiérrez Vílchez¹, T. Vázquez¹, V. López¹, M. León², E. Sola¹, J. Sellares³, M. Cobo⁴, J. Cruzado⁵, A. Torío⁶, J. Kanter⁷, P. Ruiz-Esteban¹, D. Hernández¹
¹Nephrology Service, Regional University Hospital, University of Malaga, IBIMA, REDinREN (RD16/0009/0006), Málaga, Spain, ²Pathology Department, Regional University Hospital, University of Malaga, IBIMA, REDinREN (RD16/0009/0006), Málaga, Spain, ³Nephrology Department, Hospital Vall de Hebron, Barcelona, Spain, ⁴Cardiology Department, Hospital Marqués de Valdecilla, Santander, Spain, ⁵Nephrology Department, Hospital de Bellvitge, Barcelona, Spain, ⁶Immunology, Regional University Hospital, University of Malaga, IBIMA, REDinREN (RD16/0009/0006), Málaga, Spain, ⁷Nephrology Department, Hospital Universitario Dr. Peset, Valencia, Spain
*Purpose: Steroid withdrawal can improve cardiovascular risk but little is known about its impact on graft histology and donor-specific antibodies.*Methods: 105 patients with a first…
2020 American Transplant Congress
Induction Immunosuppression in Primary Pediatric Liver Transplant Recipients
T. Shaker¹, K. Ramanathan¹, S. Riad², D. Vock³, S. Chinnakotla¹
¹Surgery, Division of Transplantation, University of Minnesota, Minneapolis, MN, ²Division of Renal Diseases and Hypertension, University of Minnesota, Minneapolis, MN, ³Biostatistics, University of Minnesota, Minneapolis, MN
*Purpose: Induction immunosuppression for pediatric liver transplants varies widely among centers. We sought to evaluate the impact of different induction regimens on patient and graft…
2020 American Transplant Congress
Comparison of 4 vs 14 Days Early Steroid Withdrawal in Kidney Transplant Recipients
O. Adebiyi, J. Chen, B. Brady, S. Mietz, T. Taber, D. Mishler, M. Yaqub, W. Goggins, A. Sharfuddin
Indiana University, Indianapolis, IN
*Purpose: The optimal duration, as well as the dose of the initial steroid use, is not known as it varies widely among institutions that have…