Articles tagged "Immunosuppression"

2020 American Transplant Congress
HMGB1 Antagonizes the Immunosuppressive Effect of MSCs in AKI
S. Cai¹, S. Wang², W. Zhang², A. Chandraker¹, C. Yang², T. Zhu²
¹Renal Division, Brigham and Women's Hospital, Boston, MA, ²Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China
*Purpose: Kidney ischemia reperfusion injury (IRI) is a common cause of acute kidney injury and an unavoidable consequence of kidney transplantation and still lacks specific…
2020 American Transplant Congress
Autophagy-Lysosome Inhibitor Chloroquine Prevents CTLA-4 Degradation of T Cells and Attenuates Acute Rejection in Murine Skin and Heart Transplantation
J. Wu
Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
*Purpose: The immune checkpoint cytotoxic T lymphocyte antigen-4 (CTLA-4), which was induced upon T cell activation but degraded quickly, has been targeted in the clinical…
2020 American Transplant Congress
Early Steroid Withdrawal in HIV+ Kidney Transplant Recipients is Associated with Increased Acute Rejection by 1 Year
W. A. Werbel¹, S. Bae², S. Yu³, F. Al-Ammary⁴, C. M. Durand¹, D. L. Segev³
¹Infectious Diseases, Johns Hopkins University, Baltimore, MD, ²Epidemiology, Johns Hopkins University, Baltimore, MD, ³Surgery, Johns Hopkins University, Baltimore, MD, ⁴Nephrology, Johns Hopkins University, Baltimore, MD
*Purpose: Kidney transplantation among HIV+ recipients (HIV+ KT) is increasing, with excellent outcomes. Acute rejection (AR), however, is 2-3-fold more common than in HIV- KT.…
2020 American Transplant Congress
Mycophenolic Acid Exposure in Young, Middle Age and Older Stable Renal Transplant Recipients
K. Tornatore¹, K. Attwood², R. Venuto³
¹School of Pharmacy; University at Buffalo, Williamsville Buffalo, NY, ²School of Pharmacy; University at Buffalo Department of Biostatistics; Roswell Park Comprehensive Cancer Center, Buffalo, NY, ³School of Medicine; University at Buffalo, Buffalo, NY
*Purpose: Mycophenolic acid (MPA) is an essential drug in maintenance immunosuppressive regimens. In spite of increased kidney transplants in the elderly, limited pharmacokinetic investigations comparing…
2020 American Transplant Congress
Kidney Transplant Results Comparing Two Formulations of Prolonged-Release Tacrolimus: Paired Study of Kidney Donors
V. Lopez Jimenez, J. Alonso Titos, J. Gamez España, M. Cabello Díaz, D. Hernández Marrero
Nephrology Department, Regional University Hospital, University of Malaga, IBIMA, REDinREN (RD16/0009/0006), Málaga, Spain
*Purpose: Although the formulations of prolonged-release tacrolimus (Advagraf® and Envarsus®) are effective after kidney transplantation in terms of efficacy and safety, no paired analysis has…
2020 American Transplant Congress
Integrated Multicohort Analysis of Transcriptome Profiles Identifies Blood Gene Signature to Distinguish Rejection from Infection in Patients with Solid Organ Transplants
L. C. Murphy, A. Rao, M. Donato, P. Khatri
School of Medicine, Stanford University, Stanford, CA
*Purpose: Allograft rejection and infection are now leading causes of morbidity and mortality in transplant recipients. Current diagnosis relies on nonspecific markers of graft injury,…
2020 American Transplant Congress
Treatment of De Novo Renal Transplant Recipients with Calcineurin Inhibitor (CNI)-Free, Belatacept+Everolimus-Based Immunosuppression
V. R. Peddi¹, B. Marder², L. Gaite³, J. Oberholzer⁴, R. Goldberg⁵, T. Pearson⁶, H. Yang⁷, L. Allamassey⁸, S. Gao⁸, M. Polinsky⁸, R. N. Formica⁹
¹California Pacific Medical Center, San Francisco, CA, ²Colorado Kidney Care, Denver, CO, ³Hospital Marqués de Valdecilla, Cantabria, Spain, ⁴UVA Health, Charlottesville, VA, ⁵Saint Barnabas Medical Center, Livingston, NJ, ⁶Emory University School of Medicine, Atlanta, GA, ⁷UPMC Pinnacle, Harrisburg, PA, ⁸Bristol-Myers Squibb, Princeton, NJ, ⁹Yale University School of Medicine, New Haven, CT
*Purpose: Compared with CNI-based immunosuppression, kidney transplant recipients receiving belatacept-based treatment present with a favorable metabolic profile, reduced chronic allograft nephropathy, and improved renal function,…
2020 American Transplant Congress
Medication Knowledge Retention and Adherence Following Transplant: Is There Room for Improvement?
M. H. Cooper¹, A. W. Rogers¹, T. L. Menser², J. C. Krisl¹
¹Department of Pharmacy, Houston Methodist Hospital, Houston, TX, ²Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX
*Purpose: Transplant recipients’ complex medication regimens following transplant can lead to non-adherence, which has been linked to increased rates of acute rejection and graft loss.…
2020 American Transplant Congress
Clinical Outcomes in Kidney Transplant Recipients Following Implementation of a Strategic Maintenance Reduction Protocol
H. Perkins, K. Foster, N. Patel, H. Meadows, F. Bartlett, C. Perez, J. McGillicuddy, N. Pilch, M. Casey, M. A. Posadas-Salas, D. Taber
Pharmacy, Medical University of South Carolina, Charleston, SC
*Purpose: Post-transplant complications are commonly due to over-immunosuppression, particularly as it relates to infections. The purpose of this study was to assess clinical outcomes in…
2020 American Transplant Congress
Association of Discharge Immunosuppressive Regimen with Treated Acute Rejection and Bronchiolitis Obliterans Syndrome in Adult Lung Transplantation: An Analysis of Organ Procurement and Transplantation Network Data
W. S. Cherikh¹, B. J. Plucinski¹, S. Palmer², W. E. Fitzsimmons³
¹United Network for Organ Sharing, Richmond, VA, ²Duke University Hospital, Durham, NC, ³Fitzsimmons LLC, Vernon Hills, IL
*Purpose: The optimal immunosuppressive (IS) regimen after lung (LU) transplant is unknown. We conducted the current analysis to compare the effect of four different discharge…