Articles tagged "Immunosuppression"

2021 American Transplant Congress
Peripheral Lymphocyte Profiling and Increased Risk of EBV Infection in Pediatric Liver Transplant Recipients
V. M. Novara Gennuso¹, T. Miloh²
¹Pediatrics, Miller School of Medicine- University of Miami, Miami, FL, ²Pediatrics, Miami Transplant Institute, Miami, FL
*Purpose: Epstein-Barr virus “EBV” infection and post-transplant lymphoproliferative disorders “PTLD” are significant comorbidities in the post-transplant “PT” setting, especially in pediatrics. The synergy among T…
2020 American Transplant Congress
Single-Cell RNA Sequencing to Assess the Effect of IL-6 Receptor Blockade in Kidney Transplantation
A. Zarinsefat, P. Rashmi, A. Da Silva, T. Sigdel, S. Chandran, Q. Tang, J. Ye, F. Vincenti, M. Sarwal
University of California San Francisco, San Francisco, CA
*Purpose: Prospective randomized study of IL-6R blockade with Tocilizumab for treatment of subclinical inflammation (SCI) in renal transplantation, reveals unique profiles of resting and stimulated…
2020 American Transplant Congress
Impact on Graft Histology of Steroid Withdrawal versus Standard Immunosuppression: Randomized, Parallel Group, Controlled Clinical Trial in Low Immunological Risk Kidney Transplant Patients
E. Gutiérrez Vílchez¹, T. Vázquez¹, V. López¹, M. León², E. Sola¹, J. Sellares³, M. Cobo⁴, J. Cruzado⁵, A. Torío⁶, J. Kanter⁷, P. Ruiz-Esteban¹, D. Hernández¹
¹Nephrology Service, Regional University Hospital, University of Malaga, IBIMA, REDinREN (RD16/0009/0006), Málaga, Spain, ²Pathology Department, Regional University Hospital, University of Malaga, IBIMA, REDinREN (RD16/0009/0006), Málaga, Spain, ³Nephrology Department, Hospital Vall de Hebron, Barcelona, Spain, ⁴Cardiology Department, Hospital Marqués de Valdecilla, Santander, Spain, ⁵Nephrology Department, Hospital de Bellvitge, Barcelona, Spain, ⁶Immunology, Regional University Hospital, University of Malaga, IBIMA, REDinREN (RD16/0009/0006), Málaga, Spain, ⁷Nephrology Department, Hospital Universitario Dr. Peset, Valencia, Spain
*Purpose: Steroid withdrawal can improve cardiovascular risk but little is known about its impact on graft histology and donor-specific antibodies.*Methods: 105 patients with a first…
2020 American Transplant Congress
Induction Immunosuppression in Primary Pediatric Liver Transplant Recipients
T. Shaker¹, K. Ramanathan¹, S. Riad², D. Vock³, S. Chinnakotla¹
¹Surgery, Division of Transplantation, University of Minnesota, Minneapolis, MN, ²Division of Renal Diseases and Hypertension, University of Minnesota, Minneapolis, MN, ³Biostatistics, University of Minnesota, Minneapolis, MN
*Purpose: Induction immunosuppression for pediatric liver transplants varies widely among centers. We sought to evaluate the impact of different induction regimens on patient and graft…
2020 American Transplant Congress
Comparison of 4 vs 14 Days Early Steroid Withdrawal in Kidney Transplant Recipients
O. Adebiyi, J. Chen, B. Brady, S. Mietz, T. Taber, D. Mishler, M. Yaqub, W. Goggins, A. Sharfuddin
Indiana University, Indianapolis, IN
*Purpose: The optimal duration, as well as the dose of the initial steroid use, is not known as it varies widely among institutions that have…
2020 American Transplant Congress
A Two-Step Cell-Based Assay Predicts Immunosuppression-Related Adverse Events in Kidney Transplant Recipients
F. Bouchard-Boivin, O. Désy, S. Béland, S. De Serres
Transplantation Unit, Renal Division, Medecine Department, Laval University, Québec, QC, Canada
*Purpose: No clinical tool is available to dynamically access immunosuppression status, which results in serious, often life-threatening adverse effects of immunosuppressants. We recently validated that…
2020 American Transplant Congress
A Single Centre Experience of Conversion from Immediate Release Tacrolimus (IR-tac) to Extended Release Envarsus
S. Chong¹, E. Kent², C. Beligaswatta², P. Gudka², C. Magee², M. Harber², R. Motallebzadeh¹, G. Jones²
¹Centre for Transplantation, Department of Renal Medicine, University College London & Royal Free London NHS Foundation Trust, London, United Kingdom, ²Department of Renal Medicine, University College London & Royal Free London NHS Foundation Trust, London, United Kingdom
*Purpose: IR-Tac is first line maintenance immunosuppression in kidney transplant recipients. Its rapid absorption of 1-2 hours can lead to peak levels (Tmax ) within…
2020 American Transplant Congress
The Importance of Annual Medicare Part D Plan Evaluation in Heart Transplantation
L. M. Lourenco
Pharmacy Services, University of Chicago Medicine, Chicago, IL
*Purpose: The Medicare open enrollment period is from Oct 15 to Dec 7, annually. The purpose of this project was to objectively measure the benefit…
2020 American Transplant Congress
Efficacy and Possible Risk of De Novo Use of Everolimus for Primary Kidney Transplantation
S. Narumi¹, Y. Watarai¹, N. Goto², T. Hiramtsu¹, M. Okada¹, K. Futamura², T. Tomosugi¹, A. Kanda², T. Kobayashi³
¹Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya City, Aichi Prefecture, Japan, ²Transplant Nephrology, Nagoya Daini Red Cross Hospital, Nagoya City, Aichi Prefecture, Japan, ³Transplant Surgery, Aichi Medical University School of Medicine, Nagakute City, Aichi Prefecture, Japan
*Purpose: Transplant outcome and protocol stay rate of everolimus were investigated to clarify efficacy and risk of everolimus based regimens at a single institute.*Methods: During…
2020 American Transplant Congress
Case Series of Belatacept for Calcineurin Inhibitor Sparing after Lung Transplantation
H. Patel, C. R. Ensor, R. D. Davis, L. Bogar, D. Colella, M. Kildea, J. Kim, A. Satterthwaite, D. Ventura, C. Gries
AdventHealth, Orlando, FL
*Purpose: Belatacept is a recombinant soluble fusion protein which selectively blocks T-cell co-stimulation. It received initial FDA approval for prophylaxis of organ rejection in Epstein-Barr…