Articles tagged "Immunosuppression"

2021 American Transplant Congress
Influence of Immunosuppressive Drug Trough Levels on Nk Cells in Liver Transplantation
R. Qin¹, J. Qin², C. Sun³, B. Nashan¹
¹Clinic for Organ Transplantation, The First Affiliated Hospital of the University of Science and Technology of China, Hefei, China, ²Clinic for Organ Transplantation, The First Affiliated Hospital of the University of Science and Technology of China., Hefei, China, ³Division of Life and Medicine, University of Science and Technology of China, Hefei, China
*Purpose: Natural killer (NK) cells are enriched in lymphocytes within the liver and are considered to be main regulators of liver transplantation (LT) rejection and…
2021 American Transplant Congress
Infection Rates in Heart Transplant Recipients With Combined Tacrolimus and Sirolimus at High versus Low Concentrations
S. Goyal, J. Lyons, J. Negrelli, M. Liebo, A. Heroux
Loyola University Medical Center, Maywood, IL
*Purpose: Assess the impact of tacrolimus-sirolimus (TAC/SRL) concentration on infection rate in heart transplant recipients (HTR).*Methods: A retrospective review of HTR on TAC/SRL for ≥…
2021 American Transplant Congress
Belatacept Conversion in Elderly Renal Transplant Recipients
M. Durst¹, D. Felix¹, M. Jorgenson¹, J. Descourouez¹, B. C. Astor², D. Mandelbrot²
¹UW Health, Madison, WI, ²University of Wisconsin School of Medicine and Public Health, Madison, WI
*Purpose: Describe the impact of conversion from a calcineurin inhibitor (CNI) based immunosuppressive regimen to belatacept in elderly renal transplant recipients.*Methods: Adult renal transplant patients…
2021 American Transplant Congress
Post Pediatric Liver Transplant Immunosuppression: What’s the Caregivers’ Perspective?
I. D. Batsis¹, J. C. Bucuvalas¹, E. Eisenberg², J. Lau², S. Feng³, E. Perito⁴
¹Pediatric Hepatology, Mount Sinai Hospital, NY, New York, NY, ²Patient and Family Engaged Partners, SPLIT, New York, NY, ³Pediatric Transplant Surgery, UCSF, San Francisco, CA, ⁴Pediatric Hepatology, UCSF, San Francisco, CA
*Purpose: For children with liver transplants (LT), achieving an “ideal outcome” is a balancing act: too little immunosuppression (IS) begets graft injury; too much IS…
2021 American Transplant Congress
Role of Baseline PD-1 Checkpoint Inhibitor Pathway Expression in Bridge to Liver Transplant Hepatocellular Carcinoma
K. Nunez, T. Sandow, M. Hibino, A. Cohen, P. Thevenot
Ochsner Health, New Orleans, LA
*Purpose: Response to first line liver-directed therapy (LDT) in hepatocellular carcinoma (HCC) has important implications in both bridge to transplant (BTT) success as well as…
2021 American Transplant Congress
Belatacept Exposure Not Associated With Rejection. Can Doses be Lowered without Compromising Efficacy?
M. McGowan¹, A. Bickenbach¹, B. Miyagawa², A. Christianson¹, T. Mizuno², P. West-Thielke³, J. Leone⁴, E. Woodle¹, D. Kaufman⁵, A. Wiseman⁶, A. Matas⁷, A. Vinks², R. Alloway¹
¹U Cincinnati, Cincinnati, OH, ²Cincinnati Children's Med Center, Cincinnati, OH, ³U Illinois, Chicago, IL, ⁴Tampa Gen, Tampa, FL, ⁵U Wisconsin, Madison, OH, ⁶Centura Transplant, Denver, CO, ⁷U Minnesota, Minneapolis, MN
*Purpose: Phase 1 and 2 belatacept(BELA) pharmacokinetic(PK) studies informed dosing in phase 3 studies. PK data from these studies revealed higher BELA troughs on Day…
2021 American Transplant Congress
Nanoparticle Mediated Drug Delivery for Lung Transplantation
P. M. Patel¹, S. Jung², C. L. Miller¹, J. M. O¹, T. Costa¹, A. Dehnadi¹, I. Hanekamp¹, X. F. Li², L. Jiang², H. Ichimura², A. Azimzadeh¹, J. C. Madsen³, R. Abdi²
¹Surgery, Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA, ²Medicine, Transplant Research Center, Brigham and Women's Hospital, Boston, MA, ³Surgery, Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA
*Purpose: Severe primary graft dysfunction (PGD) affects 30% of lung transplant patients. Pulmonary alveolar macrophages play a significant role in lung PGD, but systemic immunotherapy…
2021 American Transplant Congress
Tip60 Inhibitors Enhance Regulatory T Cells (Treg) Induction by Promoting Acetylation of Foxp3
F. Fueyo-Gonzalez¹, G. Vilanova², M. Fribourg¹
¹Department of Medicine, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, ²LaCàN, Universitat Politècnica de Catalunya-BarcelonaTech, Barcelona, Spain
*Purpose: TIP60, a histone/protein acetyltransferase essential for multiple functions in the cell, is involved in Foxp3 acetylation in Treg. Acetylation protects Foxp3 from degradation, and…
2021 American Transplant Congress
Covid vs Non Covid Pneumonia in Kidney Transplant Recipients
R. Prashar, N. Khoury, P. Shrivastava, S. Yeddula, T. Kitajima, E. Ulrich, M. Ramesh, A. Patel, S. Nagai, M. Samaniego-Picota
Henry Ford Hospital, Detroit, MI
*Purpose: Compare clinical characteristics and outcomes in kidney transplant recipients (KTRs) hospitalized with COVID vs Non COVID Pneumonia.*Methods: This is a retrospective case‐control study examining…
2021 American Transplant Congress
Avoiding Tacrolimus Under- and Overexposure with a Dosing Algorithm for Renal Transplant Recipients: A Single Arm Prospective Intervention Trial
M. I. Francke¹, L. M. Andrews², H. L. Le², J. van de Wetering¹, M. C. Clahsen-van Groningen³, T. van Gelder⁴, R. H. van Schaik⁵, B. van der Holt⁶, B. C. de Winter², D. A. Hesselink¹
¹Internal medicine, nephrology and transplantation, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ²Hospital Pharmacy, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ³Pathology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁴Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, Netherlands, ⁵Clinical Chemistry, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁶Hematology, Erasmus MC, University Medical Center, Rotterdam, Netherlands
*Purpose: Bodyweight-based tacrolimus dosing followed by therapeutic drug monitoring is standard clinical care after renal transplantation. However, after transplantation, a meagre 38% of patients is…