Articles tagged "Immunosuppression"

2021 American Transplant Congress
Modification in Immunosuppression Regimens to Safely Perform Kidney Transplants Amid the Covid-19 Pandemic
L. Von Stein, O. Witkowsky, L. Samidurai, K. Flores, M. Doraiswamy, T. Pesavento, P. Singh
The Ohio State University Wexner Medical Center, Columbus, OH
*Purpose: In the USA, there was a 51.1% reduction in kidney transplant (KTx) since March 2020 due to concerns for contraction of COVID-19 in transplant…
2021 American Transplant Congress
The Learning Curve Associated with De Novo Tacrolimus XR Use in a Racially Diverse Kidney Transplant Population
F. Bartlett, T. Carcella, N. Patel, V. Rohan, D. Taber
Medical University of South Carolina, Charleston, SC
*Purpose: Tacrolimus XR (LCP-Tac) was approved for de novo dosing in kidney transplant recipients in 2018. In 2020, our center was challenged with a nationwide…
2021 American Transplant Congress
CD47-Mediated Gli1/Notch1 Signaling is a Key Regulator of Mesenchymal Stem Cell Immunomodulation in Liver Inflammatory Injury
D. Xu, M. Sheng, Y. Lin, Y. Tian, Y. Zhan, C. Li, A. J. Coito, R. W. Busuttil, D. G. Farmer, J. W. Kupiec-Weglinski, B. Ke
Surgery, Dumont - UCLA Transplant Center, Los Angeles, CA
*Purpose: The CD47-signal regulatory protein alpha (SIRPα) signaling pathway plays important roles in immune homeostasis and tissue inflammatory response. Gli1, the downstream effector of the…
2021 American Transplant Congress
CHBP Induces Stronger Immunosuppressive CD127⁺ M-MDSC via Erythropoietin Receptor
C. Yang
Urology, Zhongshan Hospital, Fudan University, Shanghai, China
*Purpose: Erythropoietin (EPO) is not only an erythropoiesis hormone, but also an immune regulatory cytokine. The receptors of EPO, (EPOR)2 and tissue protective receptor (TPR),…
2021 American Transplant Congress
Observational Study of the Clinical Characteristics and Short-term Outcomes of Kidney Transplant Recipients Diagnosed with Coronavirus-19 Infection (sars-cov2) Requiring Hospitalization in New Orleans
S. Giusti¹, S. Chazin², P. Vaitla³, K. Atiemo⁴, M. Atari¹, A. Paramesh⁴, H. Jeon⁴, A. Vijay⁴, A. Torres⁵, M. Killackey⁴, R. Thimmisetty⁶, J. Garces⁶
¹Tulane University Section of Nephrology & Hypertension, New Orleans, LA, ²Tulane University School of Medicine, New Orleans, LA, ³University of Mississippi Medical Center, Jackson, MS, ⁴Tulane Transplant Institute, New Orleans, LA, ⁵Ochsner Medical Center, New Orleans, LA, ⁶Ochsner Multi-Organ Transplant Institute, New Orleans, LA
*Purpose: Kidney transplant recipients are at increased risk of severe disease and death caused by Coronavirus-19 infection. The role of immunosuppressive medications in the clinical…
2021 American Transplant Congress
Evaluation of Conversion to Extended-Release Tacrolimus in Abdominal Organ and Thoracic Transplant Recipients
A. Diamond¹, N. Agarwal², A. Younas², N. Sifontis², J. Au¹, C. Ruggia-Check¹
¹Pharmacy, Temple University Hospital, Philadelphia, PA, ²Pharmacy, Temple University School of Pharmacy, Philadelphia, PA
*Purpose: An established approach for conversion from immediate-release tacrolimus (IR TAC) to extended-release tacrolimus (LCPT) in kidney transplantation exists, but is lacking in other organ…
2021 American Transplant Congress
Albumin Level Prior to Liver-Directed Therapy is a Risk Factor of Waitlist Tumor Progression Independent of HCC Burden
P. Thevenot, K. Nunez, T. Sandow, M. Hibino, P. Wright, J. Patel, D. Fort, A. Cohen
Ochsner Health, New Orleans, LA
*Purpose: Milan Criteria, α-fetoprotein (AFP), and MELD score at diagnosis influence prognosis in bridge to transplant (BTT) hepatocellular carcinoma (HCC). With HCC surveillance many patients…
2021 American Transplant Congress
Leflunomide Therapy for Treatment of Bk Viremia in Pediatric Kidney Transplant Recipients
A. Aldieri¹, M. Chandran², D. Matossian³, B. Magella⁴, D. Lazear⁴, M. Bock², E. Blanchette²
¹Children's Hospital Colorado, Denver, CO, ²Children's Hospital Colorado, Aurora, CO, ³Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁴Cincinnati Children's Hospital Medical Center, Cincinnati, OH
*Purpose: BK viremia (BKV) after kidney transplantation (KT) poses significant risk for BK virus-associated nephropathy (BKVN) and impacts graft survival. Conventional treatment involves reduction of…
2021 American Transplant Congress
The Role of Notch2 in Antibody-mediated Alloimmune Response
R. Benedetti Gassen¹, N. Murakami², T. J Borges¹, A. Al Jurdi¹, A. Alessandrini¹, L. V Riella¹
¹Center of Transplantation Science, Massachusetts General Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, MA
*Purpose: Antibody mediated rejection is the leading cause of chronic allograft rejection. Developing a novel therapeutic target to inhibit chronic rejection is an urgent need…
2021 American Transplant Congress
Double Negative T Cells Mediate Cd39-Dependent Protection in Hepatic Ischemia and Reperfusion Injury
H. Jin, M. Li, C. Zhang, G. Sun, D. Zhang
Beijing Key Laboratory of Tolerance Induction and Organ Protection in Transplantation, Beijing Friendship Hospital, Capital Medical University, Beijing, China
*Purpose: Hepatic ischemia and reperfusion injury (HIRI) is a significant cause of morbidity and mortality following liver transplantation and major hepatic resections. Double negative T…