Articles tagged "Immunosuppression"

2021 American Transplant Congress
Clinical Consequences in Patients Experiencing Leukopenia and Neutropenia After Solid Organ Transplant
A. Diamond¹, N. Diehl², K. Hiryak³, K. Mortia¹, J. Au¹, C. Ruggia-Check¹, H. Clauss⁴
¹Pharmacy, Temple University Hospital, Philadelphia, PA, ²Pharmacy, UPMC Pinnacle Health, Harrisburg, PA, ³Pharmacy, Temple University School of Pharmacy, Philadelphia, PA, ⁴Infectious Diseases, Temple University Hospital, Philadelphia, PA
*Purpose: The incidence of leukopenia and neutropenia in solid organ transplant (SOT) recipients can be influenced by medications required after transplant for immunosuppression and infection…
2021 American Transplant Congress
Sirolimus (srl) versus Everolimus (evr) versus Mycophenolate (mpa) in Kidney Transplant Recipients Receiving Anti-thymocyte Globulin Induction (r-atg), Tacrolimus (tac), and Prednisone
H. Tedesco Silva Junior, C. Felipe, L. Viana, M. Cristelli, N. Tenorio, V. Lima, V. Azevedo, K. Ficher, J. Rezende, R. Foresto, M. Nakamura, Y. Dreige, J. Taddeo, C. Zito, J. Medina
Hospital do Rim, Universidade Federal de São Paulo, São Paulo, Brazil
*Purpose: The aim of this study is to compare the efficacy and safety of SRL versus EVR versus MPA in kidney transplant recipients.*Methods: This is…
2021 American Transplant Congress
Higher Calcineurin Inhibitor Levels Associate with Graft Outcomes in Kidney Recipients with De Novo Donor-specific Antibodies of Either Hla Class I or II
M. Béland, S. De Serres
Nephrology, CHU de Québec- Université Laval, Québec, QC, Canada
*Purpose: The development of de novo anti-HLA donor specific antibodies (dnDSA) is associated with poorer outcomes in kidney transplant recipients. We and other previously reported…
2021 American Transplant Congress
Characterizing Kidney Transplant Recipients with SARS-CoV-2: An Academic Single Center Experience
S. Nahi, A. Shetty, S. Tanna, J. Leventhal
Northwestern University, Chicago, IL
*Purpose: Kidney transplant (KTx) recipients are a unique cohort in regard to SARS-CoV-2 susceptibility and clinical course, owing to their immunosuppressed state and propensity for…
2021 American Transplant Congress
The Impact of De Novo Dose-Adjustment Strategies with Tacrolimus XR (LCP-Tac) in Kidney Transplant Recipients
T. Carcella, F. Bartlett, N. Patel, V. Rohan, D. Taber
Medical University of South Carolina, Charleston, SC
*Purpose: LCP-Tac is a once daily formulation of tacrolimus indicated for the prophylaxis of rejection in de novo kidney transplant recipients. It provides less variable…
2021 American Transplant Congress
Extreme Phenotype Sampling and Next Generation Sequencing to Identify Genetic Variants Associated with Tacrolimus Metabolism in African American Kidney Transplant Recipients
C. R. Dorr¹, B. Guo², B. Wu², J. Abrahante², D. Schladt³, R. Remmel², W. Guan², A. Muthusamy³, G. Onyeaghala³, N. Pankratz², A. Matas², R. Mannon⁴, W. Oetting², P. Jacobson², A. K. Israni³
¹Hennepin Healthcare Research Institute, Minneapolis, MN, ²University of Minnesota, Minneapolis, MN, ³Nephrology, Hennepin Healthcare Research Institute, Minneapolis, MN, ⁴University of Nebraska Medical Center, Omaha, NE
*Purpose: Tacrolimus (TAC) pharmacogenomics studies identified common genetic variants that alter TAC troughs suggesting strategic dosing for specific populations. Common variants and clinical factors explain…
2021 American Transplant Congress
Adjuvant Treatment Shapes the Bone Marrow Myeloid Compartment Towards an Immunosuppressive Phenotype That Can Suppress Allograft Rejection
J. Ge¹, E. Anderson¹, J. F. Markmann², A. Cuenca¹
¹Surgery, Boston Children's Hospital, Boston, MA, ²Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: Myeloid derived suppressor cells (MDSCs) expand in response to inflammatory stimuli and have been shown to suppress adaptive immunity. Preliminary data from our lab…
2021 American Transplant Congress
Influence of Immunosuppressant Management on Mortality in Kidney Transplant Recipients Hospitalized with COVID-19
Y. Fenig, A. Santeusanio, M. Menon, C. Liu, M. Rana, R. Shapiro
Mount Sinai Hospital, New York, NY
*Purpose: Kidney transplant recipients are thought to be at high risk for mortality from COVID-19 due to the necessity for chronic immunosuppressive therapy to prevent…
2021 American Transplant Congress
Effect of Early Steroid Withdrawal on Posttransplant Diabetes Mellitus Among Kidney Transplant Recipients Differs by Recipient Age
J. Ahn¹, S. Bae¹, M. Schnitzler², G. Hess³, K. Lentine², D. Segev¹, M. McAdams-DeMarco¹
¹Johns Hopkins University, Baltimore, MD, ²Saint Louis University, St. Louis, MO, ³Drexel University, Philadelphia, PA
*Purpose: Posttransplant diabetes mellitus (PTDM) is a major complication after kidney transplantation (KT) often attributable to immunosuppression. The risk of PTDM may increase with more…
2021 American Transplant Congress
Varicella Hepatitis Mimicking Immune Checkpoint Inhibitor-induced Liver Toxicity
M. J. Weiss¹, X. Zhang², E. K. Spengler¹
¹Gastroenterology and Hepatology, University of Wisconsin, Madison, WI, ²Pathology, University of Wisconsin, Madison, WI
*Purpose: Nivolumab is an anti-PD-1 monoclonal antibody belonging to a class of immune checkpoint inhibitors (ICI) used for many malignancies. A major limitation to their…