Articles tagged "Immunosuppression"

2021 American Transplant Congress
Leukopenia in the Renal Transplant Population
A. Johnson¹, G. Karadkhele², C. Larsen¹
¹Emory University, Atlanta, GA, ²Surgery, Emory University, Atlanta, GA
*Purpose: Leukopenia is a common complication for transplant patients on immunosuppression, but etiologies, timing, and outcomes are only superficially understood.*Methods: All patients undergoing kidney transplant…
2021 American Transplant Congress
Deceased Donor Transplantation Across Positive Flow Crossmatch – A Single Center Experience
M. Campara, A. Lichvar, J. Benken, S. Patel, C. Muran, D. Pierce, I. Tang, P. Di Cocco, J. Almario Alvarez, M. Spaggiari, E. Benedetti, I. Tzvetanov
University of Illinois at Chicago, Chicago, IL
*Purpose: Transplantation across a positive flow crossmatch (+FXM) has been established as a lifesaving measure in the living donor setting. Time required for desensitization limits…
2021 American Transplant Congress
Development Following Pediatric Kidney Transplantation
L. Pape, J. Prüfe
Pediatrics II, University Hospital of Essen, Essen, Germany
*Purpose: Kidney transplantation for children suffering CKD5 has been established in Germany approximately 50 years ago. While in the early decades the focus was merely…
2021 American Transplant Congress
Elevated Tacrolimus Levels in Hospitalized Organ Transplant Recipients with COVID-19
K. Mecadon¹, A. Hardesty², K. Vieira³, R. Rogers³, B. Merhi⁴, A. J. Osband⁵, G. Bayliss⁴, R. Gohh⁴, P. Morrissey⁵, D. Farmakiotis³
¹Department of Pharmacy, Rhode Island Hospital, Providence, RI, ²Department of Internal Medicine, Residency, Warren Alpert Medical School of Brown University, Providence, RI, ³Division of Infectious Diseases, Warren Alpert Medical School of Brown University, Providence, RI, ⁴Division of Nephrology, Warren Alpert Medical School of Brown University, Providence, RI, ⁵Department of Surgery (Transplantation), Warren Alpert Medical School of Brown University, Providence, RI
*Purpose: The effect of COVID-19 on immunosuppressant drug levels in organ transplant recipients (OTRs) has not been adequately studied.*Methods: We retrospectively studied hospitalized adult (>18-year-old)…
2021 American Transplant Congress
Myeloid Foxo1-β-catenin Axis Regulates Hedgehog/Gli1 Signaling and Controls NLRP3-Mediated Innate Immune Responses in Sterile Inflammatory Liver Injury
D. Xu, C. Li, M. Sheng, Y. Lin, Y. Tian, Y. Zhan, A. J. Coito, R. W. Busuttil, D. G. Farmer, J. W. Kupiec-Weglinski, B. Ke
Surgery, Dumont - UCLA Transplant Center, Los Angeles, CA
*Purpose: Foxo1 plays important roles in cell metabolism, oxidative stress, inflammation, and apoptosis. Activation of Hedgehog/Gli1 signaling regulates cell growth, differentiation, and immune function. However,…
2021 American Transplant Congress
The Metagenomic Landscape of Renal Transplant
A. Johnson¹, G. Karadkhele², C. Larsen²
¹Emory University, Atlanta, GA, ²Surgery, Emory University, Atlanta, GA
*Purpose: The selective targeting of T cells in transplant immunosuppression medications leads to a high rate of viral infections. Different immunosuppression regimens have been shown…
2021 American Transplant Congress
Immunosuppression and Cancer Risk in Kidney Transplant Recipients: A Retrospective Cohort Study
R. Sapir-Pichhadze¹, C. Laprise¹, X. Zhang¹, M. Abrahamowicz¹, M. Beauchamp², A. Della Vecchia¹, L. Azoulay¹, E. Franco¹, B. Nicolau¹
¹McGill University, Montreal, QC, Canada, ²McGill University Health Centre, Montreal, QC, Canada
*Purpose: Kidney transplant recipients (KTR) have an elevated risk of cancer. We sought to estimate to what extent does the immunosuppression regimen increase KTRs’ susceptibility…
2021 American Transplant Congress
Belatacept-Resistant T Cells are Activated by IFNα-IRF7 Pathway
F. Herr, K. Bargiel, A. Vernochet, A. Durrbach
UMR1186, Villejuif, France
*Purpose: Second signal of activation play an important role in activation of T lymphocytes. Their control by checkpoint inhibitor is efficient in auto-immune disease and…
2021 American Transplant Congress
Immunosuppression is Not Associated with High-risk Immunologic Parameters in Transplant Recipients with the Sars-cov2 Virus
S. Merl, R. Jones, B. Shonts, D. Rust, M. Sykes, J. Weiner
Medicine/Surgery, Columbia University Medical Center, New York, NY
*Purpose: The factors associated with severe COVID-19 disease in transplant patients are poorly understood. Despite concern that patients with weakened immune responses have increased risk…
2021 American Transplant Congress
Immunosuppression Regimen and Risk of Posttransplant Diabetes Among Older Kidney Transplant Recipients
K. Lentine¹, J. Ahn², M. McAdams Demarco², H. Xiao¹, S. Bunnapradist³, D. Segev², D. Axelrod¹, S. Bae², V. Dharnidharka⁴, Y. Caliskan¹, S. Chang⁴, G. Hess⁵, J. Snyder⁶, M. Schnitzler¹
¹Saint Louis Univ, Saint Louis, MO, ²Johns Hopkins, Baltimore, MD, ³Univ of California, Los Angeles, Los Angeles, CA, ⁴Washington Univ, Saint Louis, MO, ⁵Drexel Univ, Philadelphia, PA, ⁶SRTR, Minneapolis, MN
*Purpose: Posttransplant diabetes mellitus (PTDM) is a common complication after kidney transplantation (KTx), which may be exacerbated by immunosuppressive therapy (ISx). Older adults tend to…