2021 American Transplant Congress
Myeloid Foxo1-β-catenin Axis Regulates Hedgehog/Gli1 Signaling and Controls NLRP3-Mediated Innate Immune Responses in Sterile Inflammatory Liver Injury
Surgery, Dumont - UCLA Transplant Center, Los Angeles, CA
*Purpose: Foxo1 plays important roles in cell metabolism, oxidative stress, inflammation, and apoptosis. Activation of Hedgehog/Gli1 signaling regulates cell growth, differentiation, and immune function. However,…2021 American Transplant Congress
The Metagenomic Landscape of Renal Transplant
1Emory University, Atlanta, GA, 2Surgery, Emory University, Atlanta, GA
*Purpose: The selective targeting of T cells in transplant immunosuppression medications leads to a high rate of viral infections. Different immunosuppression regimens have been shown…2021 American Transplant Congress
Immunosuppression and Cancer Risk in Kidney Transplant Recipients: A Retrospective Cohort Study
1McGill University, Montreal, QC, Canada, 2McGill University Health Centre, Montreal, QC, Canada
*Purpose: Kidney transplant recipients (KTR) have an elevated risk of cancer. We sought to estimate to what extent does the immunosuppression regimen increase KTRs’ susceptibility…2021 American Transplant Congress
Belatacept-Resistant T Cells are Activated by IFNα-IRF7 Pathway
*Purpose: Second signal of activation play an important role in activation of T lymphocytes. Their control by checkpoint inhibitor is efficient in auto-immune disease and…2021 American Transplant Congress
Leukopenia in the Renal Transplant Population
1Emory University, Atlanta, GA, 2Surgery, Emory University, Atlanta, GA
*Purpose: Leukopenia is a common complication for transplant patients on immunosuppression, but etiologies, timing, and outcomes are only superficially understood.*Methods: All patients undergoing kidney transplant…2021 American Transplant Congress
Deceased Donor Transplantation Across Positive Flow Crossmatch – A Single Center Experience
University of Illinois at Chicago, Chicago, IL
*Purpose: Transplantation across a positive flow crossmatch (+FXM) has been established as a lifesaving measure in the living donor setting. Time required for desensitization limits…2021 American Transplant Congress
Development Following Pediatric Kidney Transplantation
Pediatrics II, University Hospital of Essen, Essen, Germany
*Purpose: Kidney transplantation for children suffering CKD5 has been established in Germany approximately 50 years ago. While in the early decades the focus was merely…2021 American Transplant Congress
Elevated Tacrolimus Levels in Hospitalized Organ Transplant Recipients with COVID-19
*Purpose: The effect of COVID-19 on immunosuppressant drug levels in organ transplant recipients (OTRs) has not been adequately studied.*Methods: We retrospectively studied hospitalized adult (>18-year-old)…2021 American Transplant Congress
Immunosuppression in Uterine Transplant Recipients: Experience from the Largest Uterine Transplant Program
Baylor University Medical Center at Dallas, Dallas, TX
*Purpose: Uterus transplantation (UT) is an emerging treatment in the field of total uterine infertility. There is no consensus on the optimal immunosuppression regimen in…2021 American Transplant Congress
Kidney Donor Risk Index: Significance as a Predictor of Kidney Transplant Outcomes Beyond Allograft Survival, Analysis of 18 Adjusted Regression Models Involving Adult Deceased Donor Kidney Recipients
University of Florida, Gainesville, FL
*Purpose: We aimed to study the role of kidney donor recipient index (KDRI) as a predictor for multiple transplant-related outcomes in adult deceased-donor (DD) kidney…
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