Articles tagged "Immunosuppression"

2021 American Transplant Congress
Peripheral Blood Hematopoietic Chimerism: A Robust Biomarker for Transplantation Tolerance
D. Tollerud¹, E. Gornstein¹, J. Leventhal², K. V. Ravindra³, S. Ildstad¹
¹Talaris Therapeutics, Louisville, KY, ²Division of Organ Transplantation, Northwestern Medical Group, Chicago, IL, ³Department of Surgery, Duke University Medical Center, Durham, NC
*Purpose: Despite the development of highly effective immunosuppressive medications, organ rejection and the toxicity of the drugs themselves remain significant obstacles to long-term graft and…
2021 American Transplant Congress
Impact Analysis of Virtual Transplant Ambulatory Pharmacist During Covid-19
L. Park, G. Waldman, J. Kim, C. Rogers, J. Clark
Massachusetts General Hospital, Boston, MA
*Purpose: During the COVID-19 pandemic, transplant centers were challenged to meet the demand for new telemedicine strategies. High-risk immunocompromised patients, such as lung transplant recipients…
2021 American Transplant Congress
Impaired Antibody Responses to Spike Protein Antigens of Sars-cov-2 in Solid Organ Transplant (sot) Recipients
C. Ashokkumar¹, S. Nadig², V. Rohan², A. Kroemer³, H. Dhani³, S. Rao⁴, R. Sindhi⁵
¹Plexision, pittsburgh, PA, ²Medical University of South Carolina, Charleston, SC, ³MedStar Georgetown Transplant Institute, Georgetown, DC, ⁴DHR Health Institute for Research and Development, Texas, TX, ⁵University of Pittsburgh, Pittsburgh, PA
*Purpose: Chronic immunosuppression can impair antibody responses after natural infection and vaccination in SOT recipients. It is not known whether antibody responses are impaired in…
2021 American Transplant Congress
Iguratimod Prevents Antibody-mediated Rejection by Regulating Germinal Center Formation and Antibody Production
H. Zhang, A. Chandraker, P. Sage, N. Murakami
Transplantation Research Center, Brigham and Women's Hospital, Boston, MA
*Purpose: Antibody-mediated rejection (ABMR) is a major cause of chronic renal allograft failure without effective treatment, and developing a novel therapy is an urgent need.…
2021 American Transplant Congress
Impact of New Onset Diabetes After Transplantation on Heart Transplant Recipients
W. Kang¹, W. Keattiyoat², M. Kim¹, C. Bhardwaj²
¹Department of Internal Medicine, University of Illinois College of Medicine at Peoria, Peoria, IL, ²Department of Cardiology, University of Illinois College of Medicine at Peoria, Peoria, IL
*Purpose: The purpose of this study is to investigate New Onset Diabetes After Transplantation (NODAT) incidence and its impact on post-transplant prognosis in adult heart…
2021 American Transplant Congress
A Question with Multiple Answers: Do Renal Transplant Recipients Require Steroid Maintenance Following Thymoglobulin Induction?
A. Aala, H. Patel, F. Cardarelli
Beth Israel Deaconess Medical Center, Boston, MA
*Purpose: Anti-thymocyte globulin (ATG) has been used with good results in renal transplantation as induction therapy, followed by triple immunosuppression with calcineurin inhibitors, antimetabolites, and…
2021 American Transplant Congress
Use of Donor-Derived Cell-Free DNA for Assessment of Allograft Rejection After Change in Maintenance Immunosuppression Regimens in the First Year Post Kidney Transplant
M. Walsh, V. Peev, L. Lineberger, M. Brokhof, N. Kenyon, N. Alvey
Rush University Medical Center, Chicago, IL
*Purpose: The purpose of this study was to investigate whether the use of donor-derived cell-free DNA (dd-cfDNA) is an effective screening tool for allograft rejection…
2021 American Transplant Congress
Bamlanivimab for Covid-19 in Kidney Transplant Patients
M. Y. Jan, S. El-Sayegh, M. S. Yaqub, D. P. Mishler, O. Adebiyi, M. D. Anderson, T. E. Taber, A. Sharfuddin
Nephrology, Indiana University School of Medicine, Indianapolis, IN
*Purpose: Treatment options for patients with COVID 19 have limited efficacy in reducing severity and duration of viral symptoms as well as progression to severe…
2021 American Transplant Congress
Polyfunctional T-cell Impairment to Sars-cov-2 Coronavirus in Solid Organ Transplant Recipients with Acute Covid-19 Infection
A. Favà¹, L. Donadeu², V. Pernin³, M. Meneghini¹, E. Crespo², N. Sabé⁴, L. Lladó⁵, J. Gonzalez-Costello⁶, O. Thaunat⁷, O. Bestard¹
¹Kidney Transplantation Unit, Bellvitge University Hospital- IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain, ²Experimental Nephrology Laboratory, IDIBELL, Bellvitge University Hospital, L'Hospitalet de Llobregat. Barcelona, Spain, ³Kidney Transplant Unit, Hospital de Montpellier, Montpellier, France, ⁴Infectious Disease Department, Bellvitge University Hospital, L'Hospitalet de Llobregat. Barcelona, Spain, ⁵Liver Transplant Unit, Bellvitge University Hospital, L'Hospitalet de Llobregat. Barcelona, Spain, ⁶Heart Transplantation Unit, Bellvitge University Hospital, L'Hospitalet de Llobregat. Barcelona, Spain, ⁷Department of Transplantation, Edouard Herriot Hospital Lyon, Lyon, France
*Purpose: The emerged COVID-19 pandemic caused by SARS-CoV-2 has paralyzed the world, due to its high infectivity and fatal outcomes, especially among more vulnerable individuals.…
2021 American Transplant Congress
Higher Number of Tacrolimus Dose Adjustments and Trough Level Measurements in Kidney Transplant Recipients with CYP3A5*1 Alleles
K. Reininger¹, G. Onyeaghala², T. Anderson-Haag¹, B. Wu², W. Guan², C. R. Dorr², R. Remmel², R. Mannon³, A. Matas², W. Oetting², A. Israni¹, P. Stahler¹, P. Jacobson²
¹Hennepin County Medical Center, Minneapolis, MN, ²University of Minnesota, Minneapolis, MN, ³University of Nebraska Medical Center, Omaha, NE
*Purpose: Tacrolimus (TAC) metabolism is dependent on the functional status of the cytochrome P450 family enzyme CYP3A5 which has three common loss of function (LoF)…