Articles tagged "Immunosuppression"

2021 American Transplant Congress
Development Following Pediatric Kidney Transplantation
L. Pape, J. Prüfe
Pediatrics II, University Hospital of Essen, Essen, Germany
*Purpose: Kidney transplantation for children suffering CKD5 has been established in Germany approximately 50 years ago. While in the early decades the focus was merely…
2021 American Transplant Congress
Elevated Tacrolimus Levels in Hospitalized Organ Transplant Recipients with COVID-19
K. Mecadon¹, A. Hardesty², K. Vieira³, R. Rogers³, B. Merhi⁴, A. J. Osband⁵, G. Bayliss⁴, R. Gohh⁴, P. Morrissey⁵, D. Farmakiotis³
¹Department of Pharmacy, Rhode Island Hospital, Providence, RI, ²Department of Internal Medicine, Residency, Warren Alpert Medical School of Brown University, Providence, RI, ³Division of Infectious Diseases, Warren Alpert Medical School of Brown University, Providence, RI, ⁴Division of Nephrology, Warren Alpert Medical School of Brown University, Providence, RI, ⁵Department of Surgery (Transplantation), Warren Alpert Medical School of Brown University, Providence, RI
*Purpose: The effect of COVID-19 on immunosuppressant drug levels in organ transplant recipients (OTRs) has not been adequately studied.*Methods: We retrospectively studied hospitalized adult (>18-year-old)…
2021 American Transplant Congress
Immunosuppression in Uterine Transplant Recipients: Experience from the Largest Uterine Transplant Program
N. Wilson, R. Patel, L. Johannesson, G. Testa, T. Sam
Baylor University Medical Center at Dallas, Dallas, TX
*Purpose: Uterus transplantation (UT) is an emerging treatment in the field of total uterine infertility. There is no consensus on the optimal immunosuppression regimen in…
2021 American Transplant Congress
Kidney Donor Risk Index: Significance as a Predictor of Kidney Transplant Outcomes Beyond Allograft Survival, Analysis of 18 Adjusted Regression Models Involving Adult Deceased Donor Kidney Recipients
A. Santos, E. Bueno, M. A. Leghrouz
University of Florida, Gainesville, FL
*Purpose: We aimed to study the role of kidney donor recipient index (KDRI) as a predictor for multiple transplant-related outcomes in adult deceased-donor (DD) kidney…
2021 American Transplant Congress
Clinical Value of Surveillance Biopsies in Pediatric Liver Transplantation: A Single Center Experience with >800 Biopsies
B. Rocque¹, A. Zaldana¹, C. Weaver², J. Huang¹, A. Barbetta¹, V. Shakhin², C. Goldbeck¹, G. Yanni², R. Kohli², Y. Genyk¹, J. Emamaullee¹
¹Surgery, University of Southern California Keck School of Medicine, Los Angeles, CA, ²Pediatrics, Children’s Hospital-Los Angeles, Los Angeles, CA
*Purpose: While pediatric liver transplantation (LT) results in excellent long-term outcomes, a high incidence of early acute cellular rejection (ACR) and late graft fibrosis persists.…
2021 American Transplant Congress
Suppression of T Cell Proliferation by Activated Nonhuman Primate B Cells
K. Lee, K. Deng, G. Huai, F. Qiang, C. Rickert, J. Lei, C. Leguern, J. Markmann
Massachusetts General Hospital, Boston, MA
*Purpose: We previously generated Toll-like receptor (TLR)-activated B cells in rodent settings. These B cells can suppress T cell proliferation via in vitro mixed lymphocytes…
2021 American Transplant Congress
Immunosuppression is Not Associated with High-risk Immunologic Parameters in Transplant Recipients with the Sars-cov2 Virus
S. Merl, R. Jones, B. Shonts, D. Rust, M. Sykes, J. Weiner
Medicine/Surgery, Columbia University Medical Center, New York, NY
*Purpose: The factors associated with severe COVID-19 disease in transplant patients are poorly understood. Despite concern that patients with weakened immune responses have increased risk…
2021 American Transplant Congress
Immunosuppression Regimen and Risk of Posttransplant Diabetes Among Older Kidney Transplant Recipients
K. Lentine¹, J. Ahn², M. McAdams Demarco², H. Xiao¹, S. Bunnapradist³, D. Segev², D. Axelrod¹, S. Bae², V. Dharnidharka⁴, Y. Caliskan¹, S. Chang⁴, G. Hess⁵, J. Snyder⁶, M. Schnitzler¹
¹Saint Louis Univ, Saint Louis, MO, ²Johns Hopkins, Baltimore, MD, ³Univ of California, Los Angeles, Los Angeles, CA, ⁴Washington Univ, Saint Louis, MO, ⁵Drexel Univ, Philadelphia, PA, ⁶SRTR, Minneapolis, MN
*Purpose: Posttransplant diabetes mellitus (PTDM) is a common complication after kidney transplantation (KTx), which may be exacerbated by immunosuppressive therapy (ISx). Older adults tend to…
2021 American Transplant Congress
Single Center Experience on SARS-CoV-2 Testing of Symptomatic and Asymptomatic Pediatric Kidney Transplant Recipients
H. Pizzo¹, P. R. Soni², S. Nadipuram², J. Garrison¹, D. Puliyanda¹
¹Pediatric Nephrology, Cedars-Sinai Medical Center, Los Angeles, CA, ²Pediatric Infectious Disease, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: As of late November 2020, there have been 61.5 million cases of SARS-CoV-2 (COVID-19) worldwide resulting in 1.44 million deaths. Despite the outstanding number…
2021 American Transplant Congress
Impact of Covid-19 Infection on Tacrolimus Levels in Solid Organ Transplant Recipients
K. Heagler, K. Tejani, S. Sanchez
Loyola University Medical Center, Maywood, IL
*Purpose: Immunocompromised patients are considered to be at high-risk for infection with SARS-CoV-2 (COVID-19). There have been observations within the transplant community that patients infected…