Articles tagged "Immunosuppression"

2021 American Transplant Congress
Higher Number of Tacrolimus Dose Adjustments and Trough Level Measurements in Kidney Transplant Recipients with CYP3A5*1 Alleles
K. Reininger¹, G. Onyeaghala², T. Anderson-Haag¹, B. Wu², W. Guan², C. R. Dorr², R. Remmel², R. Mannon³, A. Matas², W. Oetting², A. Israni¹, P. Stahler¹, P. Jacobson²
¹Hennepin County Medical Center, Minneapolis, MN, ²University of Minnesota, Minneapolis, MN, ³University of Nebraska Medical Center, Omaha, NE
*Purpose: Tacrolimus (TAC) metabolism is dependent on the functional status of the cytochrome P450 family enzyme CYP3A5 which has three common loss of function (LoF)…
2021 American Transplant Congress
Adenovirus-Specific T Cells for Steering of Immunosuppression After Pediatric Kidney Transplantation in the Randomized Controlled Ivist Trial
T. Ahlenstiel-Grunow¹, X. Liu², R. Schild³, J. Oh³, C. Taylan⁴, L. T. Weber⁴, H. Staude⁵, M. Verboom⁶, C. Schröder⁷, R. Sabau⁷, A. Großhennig², L. Pape¹
¹Pediatrics II, University Hospital of Essen, Essen, Germany, ²Institute of Biostatistics, Hannover Medical School, Hannover, Germany, ³Pediatric Nephrology, University Hospital Hamburg-Eppendorf, Hamburg, Germany, ⁴Pediatric Nephrology, University of Colgne, Köln, Germany, ⁵Pediatric Nephrology, University Hospital of Rostock, Rostock, Germany, ⁶Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany, ⁷Institute for Clinical Pharmacology, Hannover Medical School, Hannover, Germany
*Purpose: Pharmacokinetic monitoring alone is insufficient to estimate the intensity of immunosuppression after pediatric kidney transplantation (Tx). Levels of virus-specific T cells (Tvis) have been…
2021 American Transplant Congress
Harnessing Innate Lymphoid Cells to Prevent Graft-versus Host Disease
K. T. Reid¹, S. Q. Crome²
¹Immunology, University of Toronto, Toronto, ON, Canada, ²Ajmera Transplant Centre, TGHRI, University Health Network, Toronto, ON, Canada
*Purpose: Determine whether human innate lymphoid cells (ILCs) can be isolated, expanded and used in cell-based therapies to prevent Graft-versus Host Disease (GvHD) .*Methods: ILC2s…
2021 American Transplant Congress
Clinical Consequences in Patients Experiencing Leukopenia and Neutropenia After Solid Organ Transplant
A. Diamond¹, N. Diehl², K. Hiryak³, K. Mortia¹, J. Au¹, C. Ruggia-Check¹, H. Clauss⁴
¹Pharmacy, Temple University Hospital, Philadelphia, PA, ²Pharmacy, UPMC Pinnacle Health, Harrisburg, PA, ³Pharmacy, Temple University School of Pharmacy, Philadelphia, PA, ⁴Infectious Diseases, Temple University Hospital, Philadelphia, PA
*Purpose: The incidence of leukopenia and neutropenia in solid organ transplant (SOT) recipients can be influenced by medications required after transplant for immunosuppression and infection…
2021 American Transplant Congress
Sirolimus (srl) versus Everolimus (evr) versus Mycophenolate (mpa) in Kidney Transplant Recipients Receiving Anti-thymocyte Globulin Induction (r-atg), Tacrolimus (tac), and Prednisone
H. Tedesco Silva Junior, C. Felipe, L. Viana, M. Cristelli, N. Tenorio, V. Lima, V. Azevedo, K. Ficher, J. Rezende, R. Foresto, M. Nakamura, Y. Dreige, J. Taddeo, C. Zito, J. Medina
Hospital do Rim, Universidade Federal de São Paulo, São Paulo, Brazil
*Purpose: The aim of this study is to compare the efficacy and safety of SRL versus EVR versus MPA in kidney transplant recipients.*Methods: This is…
2021 American Transplant Congress
Higher Calcineurin Inhibitor Levels Associate with Graft Outcomes in Kidney Recipients with De Novo Donor-specific Antibodies of Either Hla Class I or II
M. Béland, S. De Serres
Nephrology, CHU de Québec- Université Laval, Québec, QC, Canada
*Purpose: The development of de novo anti-HLA donor specific antibodies (dnDSA) is associated with poorer outcomes in kidney transplant recipients. We and other previously reported…
2021 American Transplant Congress
Characterizing Kidney Transplant Recipients with SARS-CoV-2: An Academic Single Center Experience
S. Nahi, A. Shetty, S. Tanna, J. Leventhal
Northwestern University, Chicago, IL
*Purpose: Kidney transplant (KTx) recipients are a unique cohort in regard to SARS-CoV-2 susceptibility and clinical course, owing to their immunosuppressed state and propensity for…
2021 American Transplant Congress
The Impact of De Novo Dose-Adjustment Strategies with Tacrolimus XR (LCP-Tac) in Kidney Transplant Recipients
T. Carcella, F. Bartlett, N. Patel, V. Rohan, D. Taber
Medical University of South Carolina, Charleston, SC
*Purpose: LCP-Tac is a once daily formulation of tacrolimus indicated for the prophylaxis of rejection in de novo kidney transplant recipients. It provides less variable…
2021 American Transplant Congress
Extreme Phenotype Sampling and Next Generation Sequencing to Identify Genetic Variants Associated with Tacrolimus Metabolism in African American Kidney Transplant Recipients
C. R. Dorr¹, B. Guo², B. Wu², J. Abrahante², D. Schladt³, R. Remmel², W. Guan², A. Muthusamy³, G. Onyeaghala³, N. Pankratz², A. Matas², R. Mannon⁴, W. Oetting², P. Jacobson², A. K. Israni³
¹Hennepin Healthcare Research Institute, Minneapolis, MN, ²University of Minnesota, Minneapolis, MN, ³Nephrology, Hennepin Healthcare Research Institute, Minneapolis, MN, ⁴University of Nebraska Medical Center, Omaha, NE
*Purpose: Tacrolimus (TAC) pharmacogenomics studies identified common genetic variants that alter TAC troughs suggesting strategic dosing for specific populations. Common variants and clinical factors explain…
2021 American Transplant Congress
Adjuvant Treatment Shapes the Bone Marrow Myeloid Compartment Towards an Immunosuppressive Phenotype That Can Suppress Allograft Rejection
J. Ge¹, E. Anderson¹, J. F. Markmann², A. Cuenca¹
¹Surgery, Boston Children's Hospital, Boston, MA, ²Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: Myeloid derived suppressor cells (MDSCs) expand in response to inflammatory stimuli and have been shown to suppress adaptive immunity. Preliminary data from our lab…