2021 American Transplant Congress
Association of Immune Cell Markers with Adverse Outcomes in the First 6 Months Post-pediatric Heart Transplantation
*Purpose: Immunosuppression titration post-orthotopic heart transplant (OHT) is limited to trough level monitoring and does not provide data pertaining to overall state of immunosuppression. Additional…2021 American Transplant Congress
Continuous 24-Hour Antithymocyte Globulin (ATG) for Renal Allograft Rejection: Results of a Randomized Controlled Trial
Houston Methodist Hospital, Houston, TX
*Purpose: For acute renal allograft rejection (AR), ATG is generally administered in the inpatient setting because of the need for intravenous access, patient monitoring, and…2021 American Transplant Congress
Impact of Once-Daily Extended-Release Tacrolimus Intrapatient Variability in Stable Adolescent and Young Adult Renal Transplant Recipients – 3 Year Results
1Children's Hospital Colorado, Denver, CO, 2Helen DeVos Children’s Hospital, Grand Rapids, MI
*Purpose: Successful renal transplantation requires complex medication regimens that rely heavily on strict adherence to be effective. Variability in immunosuppression exposure, specifically tacrolimus, is associated…2021 American Transplant Congress
COVID-19 Transmission within One Year from Pancreas and Kidney Recipients
University of Minnesota, Minneapolis, MN
*Purpose: The current pandemic has created uncertainty surrounding the transmission of COVID-19. It was recently published that in the general population, household contacts have a…2021 American Transplant Congress
Myeloid Foxo1-β-catenin Axis Regulates Hedgehog/Gli1 Signaling and Controls NLRP3-Mediated Innate Immune Responses in Sterile Inflammatory Liver Injury
Surgery, Dumont - UCLA Transplant Center, Los Angeles, CA
*Purpose: Foxo1 plays important roles in cell metabolism, oxidative stress, inflammation, and apoptosis. Activation of Hedgehog/Gli1 signaling regulates cell growth, differentiation, and immune function. However,…2021 American Transplant Congress
The Metagenomic Landscape of Renal Transplant
1Emory University, Atlanta, GA, 2Surgery, Emory University, Atlanta, GA
*Purpose: The selective targeting of T cells in transplant immunosuppression medications leads to a high rate of viral infections. Different immunosuppression regimens have been shown…2021 American Transplant Congress
Immunosuppression and Cancer Risk in Kidney Transplant Recipients: A Retrospective Cohort Study
1McGill University, Montreal, QC, Canada, 2McGill University Health Centre, Montreal, QC, Canada
*Purpose: Kidney transplant recipients (KTR) have an elevated risk of cancer. We sought to estimate to what extent does the immunosuppression regimen increase KTRs’ susceptibility…2021 American Transplant Congress
Belatacept-Resistant T Cells are Activated by IFNα-IRF7 Pathway
*Purpose: Second signal of activation play an important role in activation of T lymphocytes. Their control by checkpoint inhibitor is efficient in auto-immune disease and…2021 American Transplant Congress
Leukopenia in the Renal Transplant Population
1Emory University, Atlanta, GA, 2Surgery, Emory University, Atlanta, GA
*Purpose: Leukopenia is a common complication for transplant patients on immunosuppression, but etiologies, timing, and outcomes are only superficially understood.*Methods: All patients undergoing kidney transplant…2021 American Transplant Congress
Deceased Donor Transplantation Across Positive Flow Crossmatch – A Single Center Experience
University of Illinois at Chicago, Chicago, IL
*Purpose: Transplantation across a positive flow crossmatch (+FXM) has been established as a lifesaving measure in the living donor setting. Time required for desensitization limits…
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