Articles tagged "Immunosuppression"

2021 American Transplant Congress
Myeloid YAP-HSF1 Signaling Inhibits NLRP3 Function and RIPK3-mediated Hepatocyte Necroptosis in Liver Ischemia and Reperfusion Injury
Y. Tian, D. Xu, M. Sheng, Y. Zhan, Y. Lin, C. Li, A. J. Coito, R. W. Busuttil, D. G. Farmer, J. W. Kupiec-Weglinski, B. Ke
Surgery, Dumont - UCLA Transplant Ctr, Los Angeles, CA
*Purpose: Yes-associated protein (YAP), a downstream effector of the Hippo pathway, tightly regulates cell growth, survival, and tissue inflammation. Activation of heat shock factor 1…
2021 American Transplant Congress
Conversion from Tacrolimus to Envarsus in Rapid Metabolizers for Prevention of BK Infection
G. Towns, G. Agarwal, C. Kew
Transplant Nephrology, UAB, Birmingham, AL
*Purpose: The incidence of BK virus infection is high among rapid metabolizers (RM) in kidney transplant (KT) patients. RM can be identified using validated and…
2021 American Transplant Congress
Sharp Anti-HLA Antibody Development Due to Concomitant Graft Nephrectomy and Immunosuppression Withdrawal After Early Graft Loss
R. Valero¹, A. Aguilera¹, E. Rodrigo¹, D. San Segundo², M. Lopez-Hoyos², J. Ruiz¹
¹Nefrología, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ²Inmunología, Hospital Universitario Marqués de Valdecilla, Santander, Spain
*Purpose: The number of patients awaiting for retransplantation has been progressively increasing. The presence of anti-HLA antibodies can significantly lengthen the waiting time, limiting the…
2021 American Transplant Congress
Symptoms on MTSOSD Questionnaire in Pancreas Transplantation Recipients
R. Kaur, S. R. Rizvi, B. H. Smith, C. Reid, S. K. McCrady-Spitzer, W. K. Kremers, P. G. Dean, A. Kukla, M. D. Stegall, Y. C. Kudva
Mayo Clinic, Rochester, MN
*Purpose: We used the Modified transplant symptom Occurrence and symptom distress scale (MTSOSD) to study side-effects of immunosuppression after Pancreas transplantation (PT) for patients with…
2021 American Transplant Congress
Impact of Cypa5 Status on the Clinical and Financial Outcomes of Kidney Transplant
J. Obayemi¹, B. Keating², K. Lentine³, M. Schnitzler³, H. Xiao³, V. Dharnidharka⁴, D. Axelrod⁵
¹Univ of Michigan, Ann Arbor, MI, ²Univ of Pennsylvania, Philadelphia, PA, ³Saint Louis Univ, Saint Louis, MO, ⁴Washington Univ, Seattle, WA, ⁵Univ of Iowa, Iowa City, IA
*Purpose: Pharmacogenetic profiling of transplant recipients has demonstrated marked variation in the metabolism of immunosuppressive medications, particularly tacrolimus. Patients of African ancestry have been found…
2021 American Transplant Congress
Immunosuppression Reduction Strategies for Polyoma BK Viremia in Kidney Transplant Patients on Belatacept-Based Immunosuppression
O. Roe¹, E. Meredith¹, A. Reid², A. Basu³
¹Emory University Hospital, Atlanta, GA, ²University of California San Francisco Medical Center, San Francisco, CA, ³Emory Transplant Center, Atlanta, GA
*Purpose: The mainstay of treatment for BK infection is immunosuppression (IS) reduction, however limited literature provides guidance for treatment of patients with a belatacept-based IS…
2021 American Transplant Congress
Belatacept for Kidney Transplantation in the Age of Covid19, is it Safe?
J. Pagan¹, S. Anjan², Y. Natori³, A. Fernandez³, R. Zamora-Gonzalez², A. Mattiazzi¹, L. Mendez¹, G. Guerra¹
¹Nephrology, University of Miami, Miami, FL, ²Infectious Diseases, University of Miami, Miami, FL, ³Infectious Disease, University of Miami, Miami, FL
*Purpose: The COVID19 pandemic has affected kidney transplant recipients (KTR) with a wide spectrum of clinical severity. Up to this point, we have solely seen…
2021 American Transplant Congress
Remote Monitoring Using Mobile Phlebotomy and Donor-derived Cell-free DNA in Kidney Transplant Recipients During the Covid-19 Pandemic
N. Ali¹, J. Miles², V. Tatapudi¹, R. Montgomery¹
¹NYU Langone, New York, NY, ²Medical Science Liason, CareDx, Brisbane, CA
*Purpose: The rapid shift to telemedicine and remote monitoring of kidney transplant recipients (KTRs) during COVID-19 aimed to mitigate exposure risk for this vulnerable population.…
2021 American Transplant Congress
The Impact of High Kdpi on 1-year Post-transplant Graft Function and Survival in a Brazilian Cohort
H. Tedesco Silva Junior, R. Demarchi Foresto, M. Hazin, B. Cassão, A. Aquino, J. Taddeo, C. Rosso Felipe, L. Requião Moura, J. Medina
Núcleo de Ensino e Pesquisa, Hospital do Rim, Universidade Federal de São Paulo, São Paulo, Brazil
*Purpose: To evaluate the impact of High Kidney Donor Profile Index (KDPI) on 1-year post-transplant renal function and graft survival.*Methods: This retrospective cohort analyzed 3,059…
2021 American Transplant Congress
Pill Burden in Belatacept versus Tacrolimus-Based Immunosuppression
S. Gattis, L. Lakhani, A. Basu
Emory Healthcare, Atlanta, GA
*Purpose: Medication non-adherence is a major barrier amongst renal transplant recipients, and improvement can be seen after reduction in pill burden. Belatacept versus tacrolimus-based immunosuppression…