Articles tagged "Immunosuppression"

2022 American Transplant Congress
Development of a Patient-Reported Outcome Measure of Neurological Side Effects from Immunosuppression in Kidney Transplant Recipients
C. Hurt¹, G. J. Greene¹, J. Friedewald², D. P. Ladner², A. Waterman³, D. Cella¹, D. Peipert¹
¹Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Surgery and J.C. Walter Jr. Transplant Center, Houston Methodist Hospital, Houston, TX
*Purpose: Though kidney transplant is the optimal treatment for most individuals with end stage kidney disease, recipients experience significant side effects associated with their required…
2022 American Transplant Congress
Impact of Immunosuppressive Medications on SARS-CoV-2 Vaccination Response in Kidney Transplant Patients
O. Sogbein¹, A. Rizvi², M. Mujtaba³, M. Kueht⁴, J. Fair⁴, A. Gamilla-Crudo³, S. Hussain⁵
¹Internal Medicine, Division of Nephrology, University of Texas Medical Branch, Galveston, TX, ²Internal Medicine, Nephrology, University of Texas Medical Branch at Galveston, Galveston, TX, ³University of Texas Medical Branch, Galveston, TX, ⁴Surgery, University of Texas Medical Branch, Galveston, TX, ⁵University of Texas Medical Branch, Houston, TX
*Purpose: The COVID-19 pandemic portends significant morbidity and mortality in immunocompromised individuals. Vaccination against COVID-19 among immunocompromised population is an essential step to minimize deadly…
2022 American Transplant Congress
Recipient and Grafts Outcomes in Simultaneous Kidney and Pancreas Transplantation with Steroid Avoidance in the United States
A. Cerise¹, A. Dinesh², V. Humphreville², S. Jackson³, R. Kandaswamy², S. Riad⁴
¹Surgery, University of Minnesota, Minnesota, MN, ²Surgery, University of Minnesota, Minneapolis, MN, ³Analytics, MHealth-Fairview, Minneapolis, MN, ⁴Medicine, University of Minnesota, Eden Prairie, MN
*Purpose: Steroid avoidance in kidney transplantation has been proven non-inferior. Data on steroid avoidance in simultaneous pancreas-kidney (SPK) is scant.*Methods: We utilized the Scientific Registry…
2022 American Transplant Congress
Use of Dd-cfdna to Guide Tapering of Immunosuppression Therapy in Kidney Transplant Recipients
G. Osuchukwu¹, A. Trevino¹, L. Beretich², S. McCormick², N. Kaur², R. White², P. Gauthier²
¹Victoria Kidney and Dialysis Associates, Victoria, TX, ²Natera, Inc., Austin, TX
*Purpose: Continuous administration of immunosuppressive therapy (IST) is required to avoid allograft rejection in transplant recipients. However, these therapeutic interventions can lead to significant side…
2022 American Transplant Congress
How Does Anti-CD38 Antibody Treatment (Daratumumab) Impact Immunological Assessment in Solid Organ Transplantation?
S. Ho¹, K. Putnam², C. Peiter², W. Herczyk², J. Gerlach³, E. Campagnaro⁴, Y. Lu⁴, K. Woodside⁴, M. Cusick⁴
¹Gift of Hope Organ & Tissue Donor Network, Itasca, IL, ²Gift of Life Michigan, Ann Arbor, MI, ³Michigan State University, East Lansing, MI, ⁴University of Michigan Medicine, Ann Arbor, MI
*Purpose: We report the first case of Dara interference of routine pre-transplant (Tx) crossmatch (XM) repeatedly causing aberrant false positives which inadvertently delayed Tx for…
2021 American Transplant Congress
Myeloid Foxo1-β-catenin Axis Regulates Hedgehog/Gli1 Signaling and Controls NLRP3-Mediated Innate Immune Responses in Sterile Inflammatory Liver Injury
D. Xu, C. Li, M. Sheng, Y. Lin, Y. Tian, Y. Zhan, A. J. Coito, R. W. Busuttil, D. G. Farmer, J. W. Kupiec-Weglinski, B. Ke
Surgery, Dumont - UCLA Transplant Center, Los Angeles, CA
*Purpose: Foxo1 plays important roles in cell metabolism, oxidative stress, inflammation, and apoptosis. Activation of Hedgehog/Gli1 signaling regulates cell growth, differentiation, and immune function. However,…
2021 American Transplant Congress
The Metagenomic Landscape of Renal Transplant
A. Johnson¹, G. Karadkhele², C. Larsen²
¹Emory University, Atlanta, GA, ²Surgery, Emory University, Atlanta, GA
*Purpose: The selective targeting of T cells in transplant immunosuppression medications leads to a high rate of viral infections. Different immunosuppression regimens have been shown…
2021 American Transplant Congress
Immunosuppression and Cancer Risk in Kidney Transplant Recipients: A Retrospective Cohort Study
R. Sapir-Pichhadze¹, C. Laprise¹, X. Zhang¹, M. Abrahamowicz¹, M. Beauchamp², A. Della Vecchia¹, L. Azoulay¹, E. Franco¹, B. Nicolau¹
¹McGill University, Montreal, QC, Canada, ²McGill University Health Centre, Montreal, QC, Canada
*Purpose: Kidney transplant recipients (KTR) have an elevated risk of cancer. We sought to estimate to what extent does the immunosuppression regimen increase KTRs’ susceptibility…
2021 American Transplant Congress
Belatacept-Resistant T Cells are Activated by IFNα-IRF7 Pathway
F. Herr, K. Bargiel, A. Vernochet, A. Durrbach
UMR1186, Villejuif, France
*Purpose: Second signal of activation play an important role in activation of T lymphocytes. Their control by checkpoint inhibitor is efficient in auto-immune disease and…
2021 American Transplant Congress
Leukopenia in the Renal Transplant Population
A. Johnson¹, G. Karadkhele², C. Larsen¹
¹Emory University, Atlanta, GA, ²Surgery, Emory University, Atlanta, GA
*Purpose: Leukopenia is a common complication for transplant patients on immunosuppression, but etiologies, timing, and outcomes are only superficially understood.*Methods: All patients undergoing kidney transplant…