Articles tagged "Immunosuppression"

2022 American Transplant Congress
Impact of Biliary Reconstruction on Tacrolimus Absorption in Pediatric Liver Transplant
M. Chandran¹, D. Yoeli¹, A. Sater², M. Adams¹, F. Karrer¹
¹Children's Hospital Colorado, Aurora, CO, ²University of Colorado, Aurora, CO
*Purpose: Tacrolimus (FK506) oral bioavailability in pediatric liver transplant recipients (LTR) is poor. Enteral FK506 is primarily absorbed in the small intestine and subject to…
2022 American Transplant Congress
Real-Life Tacrolimus Levels Are Associated with Biopsy-Proven Acute Rejection After the First Year Post-Kidney Transplantation
S. Meziyerh, T. van Gelder, D. van der Helm, P. J. van der Boog, J. W. de Fijter, D. J. Moes, A. P. de Vries
LUMC, Leiden, Netherlands
*Purpose: Evidence to recommend specific target concentrations for immunosuppression beyond the first year of kidney transplantation (KT) is limited. We correlated real-life exposure data of…
2022 American Transplant Congress
Use of Organ-Specific Chimeric Antigen Receptor Promotes Liver Recruitment of Regulatory T Cells
E. Landmann¹, P. Ruiz¹, A. Kurt¹, E. Kodela¹, M. Martinez-Llordella², A. Sanchez-Fueyo¹
¹King's College London, London, United Kingdom, ²Quell Therapeutics, London, United Kingdom
*Purpose: Owing to their potent immune-modulatory properties, regulatory T cells (Tregs) have been explored as novel cell therapy to induce allograft tolerance, with first clinical…
2022 American Transplant Congress
Results of a Pilot Adherence Activity for Pharmacy Learners on a Solid Organ Transplant Service
J. Zumbrunnen
Pharmacy, Emory University Hospital, Atlanta, GA
*Purpose: The purpose was to determine if the ability of pharmacy learners to educate patients and help overcome barriers to medication adherence is improved after…
2022 American Transplant Congress
The Promise Of Tolerance In Living Donor Kidney Transplant (LDKT): A Retrospective, Real-world Assessment Of The Safety And Efficacy Of LDKT With FCR001 Investigational Cell-therapy Compared With Standard Of Care (SOC)
N. Krieger¹, J. R. Leventhal², B. Ho³, M. Richards⁴, D. Schaumberg⁴, S. Ildstad⁵, D. Axelrod⁶
¹Talaris Therapeutics, Inc, Wellesley, MA, ²SURGERY, Northwestern Medicine, Chicago, IL, ³Comprehensive Transplant Ctr, Chicago, IL, ⁴Evidera, Bethesda, MD, ⁵Talaris Therapeutics, Inc., Louisville, KY, ⁶University of Iowa, Iowa City, IA
*Purpose: FCR001 (FCR) is a cell therapy derived from mobilized donor PBMCs including hematopoietic progenitor cells, facilitating cells, and αβ T cells, intended to establish…
2021 American Transplant Congress
Effects of Timing of Everolimus Transition on Renal Outcomes in Liver Transplant Recipients
M. Leick¹, H. Belleau², T. McCashland³
¹Nebraska Medicine, Omaha, NE, ²Bryan Health, Lincoln, NE, ³University of Nebraska Medical Center, Omaha, NE
*Purpose: The purpose of this study is to evaluate the effects of the timing of everolimus transition on renal outcomes in liver transplant recipients.*Methods: This…
2021 American Transplant Congress
Laminins Differentially Regulate Adaptive Alloimmune Responses
L. Li¹, M. Shirkey¹, W. Piao¹, Y. Xiong¹, V. Saxena¹, T. Zhang¹, J. Iyyathurai², R. Lakhan¹, R. Abdi³, J. Bromberg¹
¹Surgery, UMB, Baltimore, MD, ²CVID, UMB, Baltimore, MD, ³Harvard University, Boston, MA
*Purpose: Lymph node (LN) stromal cell expressed laminin α4 (Lama4) and laminin α5 (Lama5) fibers are associated with tolerance and immunity, respectively. They regulate cell…
2021 American Transplant Congress
Selective Regulatory T Cell Expansion by a Novel IL-2 Mutein Prolongs Skin Transplant Survival in Mice
T. J. Borges¹, O. Effe¹, R. B. Gassen¹, A. Al Jurdi¹, I. T. Lape¹, G. J. Babcock², S. M. Carlson², J. C. Madsen¹, L. V. Riella¹
¹Center For Transplantation Sciences, Massachusetts General Hospital, Charlestown, MA, ²Visterra, Inc., Waltham, MA
*Purpose: Long-term immunosuppression predisposes transplant patients to a greater risk of infection, malignancy and kidney toxicity. Hence, alternative methods to regulate the immune system are…
2021 American Transplant Congress
Myeloid YAP-HSF1 Signaling Inhibits NLRP3 Function and RIPK3-mediated Hepatocyte Necroptosis in Liver Ischemia and Reperfusion Injury
Y. Tian, D. Xu, M. Sheng, Y. Zhan, Y. Lin, C. Li, A. J. Coito, R. W. Busuttil, D. G. Farmer, J. W. Kupiec-Weglinski, B. Ke
Surgery, Dumont - UCLA Transplant Ctr, Los Angeles, CA
*Purpose: Yes-associated protein (YAP), a downstream effector of the Hippo pathway, tightly regulates cell growth, survival, and tissue inflammation. Activation of heat shock factor 1…
2021 American Transplant Congress
Conversion from Tacrolimus to Envarsus in Rapid Metabolizers for Prevention of BK Infection
G. Towns, G. Agarwal, C. Kew
Transplant Nephrology, UAB, Birmingham, AL
*Purpose: The incidence of BK virus infection is high among rapid metabolizers (RM) in kidney transplant (KT) patients. RM can be identified using validated and…