Articles tagged "Immunosuppression"

2015 American Transplant Congress
Eomesodermin Expression By Alloreactive Non-Human Primate CD8+ Memory T Cells: Influence of CTLA4Ig and Regulatory DC Infusion in Renal Allograft Recipients
M. Ezzelarab,¹ L. Lu,¹ H. Guo,¹ A. Zahorchak,¹ W. Shufesky,¹ D. Cooper,¹ A. Morelli,^1,2 A. Thomson.^1,2
¹Surgery - Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA; ²Immunology, University of Pittsburgh, Pittsburgh, PA.
Background:Memory T cells (Tmem), particularly those resistant to costimulation blockade (CoSB), are considered a major barrier to transplant tolerance. The T-box transcription factor Eomesodermin (Eomes)…
2015 American Transplant Congress
The Influence of Immunosuppressive Drugs On the Epithelial Microenvironment in Solid Organ Transplantation – Identification of Biomarker Candidates for Rejection Vs. Tolerance
A. Akhdar,¹ B. Mueller,² C. Neudoerfl,¹ F. Lehner,³ M. Stevanovic-Meyer,¹ K. Daemen,¹ J. Keil,¹ H. Haller,⁴ C. Blume,^4,5 C. Falk.^1,6
¹Institute of Transplant Immunology, IFB-Tx, Hanover Medical School, Hanover, Germany; ²MorphoSys, Munich, Germany; ³Department of General, Visceral and Transplantation Surgery, Hanover Medical School, Hanover, Germany; ⁴Department of Nephrology and Hypertension, Hanover Medical School, Hanover, Germany; ⁵Institute of Technical Chemistry, Leibniz University Hanover, Hanover, Germany; ⁶German Center for Infection Research, Braunschweig, Germany.
In the context of kidney transplantation, NK cells may play an important role by targeting the allogeneic organ due to "missing-self recognition", which leads to…
2015 American Transplant Congress
2-Year Results on Renal Function and Safety for Everolimus plus Reduced-Exposure Calcineurin Inhibitor in Living Donor Kidney Transplant Recipients
T. Yagisawa,¹ N. Ishikawa,¹ N. Goto,² I. Nakajima,³ O. Kamisawa,⁴ S. Fuchinoue.³
¹Division of Renal and Transplantation, Jichi Medical University, Shimotsuke, Japan; ²Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan; ³Surgery, Kidney Center, Tokyo Women's University, Tokyo, Japan; ⁴Medical Division, Novartis Pharma K.K., Tokyo, Japan.
Purpose: The long-term effects of everolimus (EVR) with reduced cyclosporine (rCsA) exposure over 24 months on renal function and safety (viral infection) were assessed in…
2015 American Transplant Congress
T-Cell Immune Function Vs. Gene Expression Profiling for Heart Transplant Rejection
M. Luu, M. Kittleson, J. Patel, F. Liou, S. Siddiqui, L. Piponniau, A. Hage, D. Chang, L. Czer, A. Trento, J. Kobashigawa.
Cedars-Sinai Heart Institute, Los Angeles, CA.
Purpose: Non-invasive immune monitoring of heart transplant (HTx) patients (pts) is increasing in use. The AlloMap® blood test has proven helpful in surveillance of cardiac…