Articles tagged "Immunosuppression"

2015 American Transplant Congress
Transplantation of Kidneys from Donors With Acute Renal Failure: Five-Year Results from Double Center Experience
C. Ramirez,^1,2 A. Safra,¹ A. Shah,^1,2 C. Doria,¹ W. Maley,¹ A. Frank,¹ C. Gorn,¹ L. Lerner.²
¹Department of Surgery, Division of Transplantation, Thomas Jefferson University Hospital, Philadelphia, PA; ²Department of Kidney Transplantation, Lankenau Medical Center, Wynnewood, PA.
Background: Transplantation of kidneys from deceased donors with acute renal failure (ARF) has been described and represents an underutilized source of renal grafts. We reviewed…
2015 American Transplant Congress
High Intra-Patient Variability in Tacrolimus Trough Blood Levels Increases the Risk of Death-Censored Graft Loss After Kidney Transplantation
E. Rodrigo,¹ D. San Segundo,² J. Ruiz,¹ M. López-Hoyos,² A. Benito,¹ M. de Cos,³ Z. Albines,¹ M. Serrano,¹ M. Arias.¹
¹Nephrology, University Hospital Marqués de Valdecilla, Santander, Cantabria, Spain; ²Immunology, University Hospital Marqués de Valdecilla, Santander, Cantabria, Spain; ³Pharmacology, University Hospital Marqués de Valdecilla, Santander, Cantabria, Spain.
Kidney graft loss rates beyond the first year showed only small improvements over past decades. Advances in maintenance immunosuppressive therapy contributed to the improvements seen…
2015 American Transplant Congress
Do Induction Therapy, Patient-Level and Post-Operative Factors Impact Outcomes in Moderate to High Immunologic Risk Simultaneous Kidney-Pancreas Transplantation in the Era of Stringent HLA Cross-Matching?
V. Rohan, D. Taber, D. Taraskiewicz, S. Nadig, J. Mcgillicuddy, K. Chavin, P. Baliga, C. Bratton.
MUSC, Charleston, SC.
Background: Simultaneous kidney and pancreas transplantation (SPK) is a lifesaving procedure for patients with diabetes mellitus. The success of SPK is dependent upon minimization of…
2015 American Transplant Congress
Effect of Distinct Immunosuppressive Protocols On the Profile of Cytokines Expression in Renal Transplant Recipients of Extended Criteria Donor Kidneys
C. Montoro Mazeti,¹ C. Zangrossi Dezotti,¹ I. Fernandes-Charpiot,^1,2 H. Caldas,¹ M. Baptista,^1,2 M. Abbud Filho.^1,2,3
¹Laboratory of Immunology and Experimental Transplantation, Sao Jose do Rio Preto Medical School, Sao Jose do Rio Preto, SP, Brazil; ²Department of Medicine, Division of Nephrology, Sao Jose do Rio Preto Medical School, Sao Jose do Rio Preto, SP, Brazil; ³Urology and Nephrology Institute, Urology and Nephrology Institute, Sao Jose do Rio Preto, SP, Brazil.
Background: Transplant recipients (RTx) of kidneys classified as extended criteria (ECD) seems to have worst outcomes when compared with RTx of standard kidneys (SCD) and…
2015 American Transplant Congress
NFAT Regulated Cytokine Gene Expression for Immune Monitoring in Kidney Transplant Recipients
V. Tatapudi, A. Webber, C. Leung, F. Vincenti.
Div. of Nephrology, Dept. of Medicine, University of California, San Francisco Medical Center, San Francisco, CA.
Purpose of Study:To demonstrate that profiling kidney transplant recipients (KTR) on Tacrolimus (Tac) based immunosuppression based on quantitative analysis of NFAT (nuclear factor of activated…
2015 American Transplant Congress
Long-Term Follow-Up After Conversion from Twice-Daily Tacrolimus Formulation to Once-Daily Tacrolimus Formulation in Pediatric Kidney Transplantation
C. Choi, A. Han, S. Min, S.-K. Min, T. Lee, I.-M. Jung, S. Kim, J. Ha.
Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea.
PurposeTacrolimus is one of the most frequently used immunosuppressants in pediatric kidney transplantation (KT) as in adult. In Pediatric kidney recipients, it is more important…
2015 American Transplant Congress
Immunomodulatory Effects of Neuropilin-2 On T Cells
H. Nakayama,^1,2 N. Kochupurakkal,¹ S. Bruneau,¹ D. Bielenberg,² M. Klagsbrun,² D. Briscoe.¹
¹Transplant Research Program, Boston Children's Hospital, Boston, MA; ²Vascular Biology Program, Boston Children's Hospital, Boston, MA.
Axonal guidance molecules are expressed within the immune system and elicit anti-inflammatory effects with potential to target auto- and alloimmunity. The neuropilin (NRP) family receptors…
2015 American Transplant Congress
Risk Stratification in Tailoring Induction Therapy in Kidney Transplant Recipients(KTR): Is It Cost-Effective?
B. Sirandas, A. Carlson, N. Kenyon, C. Truax, L. Smith.
Transplant, Univ. of Utah, Salt Lake City, UT.
Intro: Selecting induction therapy based on immunologic risk in KTR has gained popularity but there has yet to be a study evaluating the cost beyond…
2015 American Transplant Congress
Adverse Events of Maintenance Immunosuppression Following Kidney Transplantation Reported in Randomized Controlled Trials: A Systematic Review
M. Howell,^1,2 R. Yeo,² A. Tong,^1,2 J. Craig,^1,2 K. Howard,² G. Wong.^2,3
¹Centre for Kidney Research, The Children's Hospital at Westmead, Westmeand, NSW, Australia; ²School of Public Health, University of Sydney, Sydney, NSW, Australia; ³Centre for Transplant and Renal Research, Westmead Hospital, Westmead, NSW, Australia.
Aim: To evaluate the completeness of reporting of adverse events in randomized controlled trials (RCTs) of maintenance immunosuppression in kidney transplantation.Background: Side effects of maintenance…
2015 American Transplant Congress
Efficacy and Safety of Induction Therapy With Monoclonal Versus Polyclonal Antibodies in Kidney Transplant Recipients in the Last Five Years (2008-2013) in Our Institution
M. Fernández, M. López, M. Ferreira, A. Aguilar, C. Jiménez, R. Selgas.
Nephrology, La Paz Hospital, Madrid, Spain.
Induction immunosuppression in renal transplantation is not clearly defined. We analyze the efficacy and safety of the used regimens at our institution in the last…