2015 American Transplant Congress
Reduced Intensity Immunosuppression Protocol Lowers Drug Costs and May Decrease Incidences of BK Viremia and Readmissions After Kidney and Kidney/Pancreas Transplant
Purpose: To evaluate the effects of a reduced intensity immunosuppression protocol on drug costs and rates of BK viremia and readmissions.Methods: In response to high…2015 American Transplant Congress
Long-Term Results After Heart Transplantation – A Randomized Trial Comparing Tacrolimus Versus Cyclosporine A in Combination With Mycophenolate Mofetil After a Mean Duration of 15 Years
Purpose. Development of cardiac allograft vasculopathy (CAV), renal dysfunction and malignancies are the main risks due to long-term immunosuppressive therapy after heart transplantation (HTx). We…2015 American Transplant Congress
Short- and Long-Term Outcomes of Mycophenolate Versus Azathioprine in a Large Cohort of Renal Transplant Recipients
1Barnes-Jewish Hospital, St. Louis; 2Washington University School of Medicine, St. Louis.
Purpose: Early studies comparing mycophenolate mofetil (MMF) to azathioprine (AZA) post-renal transplantation demonstrated superiority of MMF over AZA for the prevention of acute rejection (AR).…2015 American Transplant Congress
CFZ533: Assessment of Immunomodulatory Activity Following Single Doses of a Novel Anti-CD40 mAb in Healthy Volunteers
Blocking the CD40-CD154 pathway has been shown to effectively prolong renal allograft survival in non-human primates. CFZ533 is a novel, fully human, Fc-silent, anti-CD40 monoclonal…2015 American Transplant Congress
Adherence Time-Profiles of Renal Transplant Patients During the Three First Years Post-Transplantation
Non-adherence to immunosuppressants (IS) has been reported to increase morbidity and mortality of transplant patients.Our objective was to investigate adherence to IS in renal transplant…2015 American Transplant Congress
Forty-Seven Consecutive Simultaneous Liver-Kidney Transplants With Steroid Free Immunosuppression After Rabbit Antithymocyte Globulin Induction
Introduction: Utilization of rabbit antithymocyte globulin (RATG) induction as part of a steroid free immunosuppression protocol in orthotopic liver transplantation has gained wide acceptance in…2015 American Transplant Congress
DNA Methytransferase 1 Inhibition Potently Suppresses T Cell Cycle Progression Through Demethylation of the Key Cell Cycle Inhibitors p15, p16, p21 and p27
Background: Epigenetic mechanisms like acetylation and methylation have been gradually appreciated to play a critical role in the generation and function of various immune cells.…2015 American Transplant Congress
Living and Dead Mesenchymal Stem Cells Induce an Immunosuppressive Response in an Experimental Sepsis Model
There is evolving interest in the use of mesenchymal stem cells (MSC) as a cell therapeutic agent after solid organ transplantation. The nature of the…2015 American Transplant Congress
Induction Avoidance in 2-Haplotype-Matched White Living Kidney Transplantation
Background: We hypothesize that 2-haplotype matched white living kidney transplant recipients carry a low immunologic risk for rejection, and therefore do not give induction therapy…2015 American Transplant Congress
Medication Non-Adherence in Those Waiting for a Transplant
Purpose: Though poor medication adherence among adult kidney transplant patients is alarmingly high with distressing consequences, no one has systematically examined medication non-adherence in those…
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