ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Immunosuppression"

  • 2015 American Transplant Congress

    Induction Avoidance in 2-Haplotype-Matched White Living Kidney Transplantation

    Z. Brifkani,1 T. Alhamad,1 T. Horwedel,2 R. Delos Santos,1 T. Maw,1 D. Brennan.1

    1Transplant Nephrology, Washington University in St. Louis, St. Louis, MO; 2Barnes Jewish Hospital, St. Louis, MO.

    Background: We hypothesize that 2-haplotype matched white living kidney transplant recipients carry a low immunologic risk for rejection, and therefore do not give induction therapy…
  • 2015 American Transplant Congress

    Medication Non-Adherence in Those Waiting for a Transplant

    M. Wakefield,1 D. Murillo,2 C. Russell,3 C. Ashbaugh,1 S. Potts,2 L. Blakley,2 A. Deere.1

    1Department of Surgery, University of Missouri, Columbia, MO; 2Transplant Institute, Research Hospital, Kansas City, MO; 3School of Nursing and Health Studies, University of Missouri-Kansas City, Kansas City, MO.

    Purpose: Though poor medication adherence among adult kidney transplant patients is alarmingly high with distressing consequences, no one has systematically examined medication non-adherence in those…
  • 2015 American Transplant Congress

    Assessment of Viral-Specific Memory T Cell Responses and Infection Rates in HLA-Sensitized (HS) Kidney Transplant Patients (Tx Pts) Treated With Everolimus & Low-Dose Tacrolimus (Eve/Tac)

    S. Ge, J. Kahwaji, M. Chu, A. Karasyov, M. Castro, E. Hayrapetyan, D. Lovato, D. Thomas, J. Choi, S. Louie, A. Vo, S. Jordan, M. Toyoda.

    Transplant Immunology & Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles.

    Background: mTOR inhibitors stimulate viral-specific memory CD8+ T cell differentiation and increase viral clearance in infected Tx pts. HS pts desensitized (DES) with IVIG +…
  • 2015 American Transplant Congress

    24 Month Post Transplantation Follow Up of the Certitem Trial

    E. Rondeau,1 E. Cassuto,2 V. Vuiblet,3 C. Legendre,4 P. Merville,5 Y. Le Meur,6 B. Moulin,7 P. Westeel,8 B. Hurault De Ligny,9 A. Lécuyer,10 M. Tindel,11 N. Kamar.12

    1Hôpital Tenon, Paris, France; 2Hôpital Pasteur, Nice, France; 3Hôpital Maison Blanche, Reims, France; 4Hôpital Necker, Paris, France; 5Hôpital Pellegrin, Bordeaux, France; 6Hôpital La Cavale Blanche, Brest, France; 7Nouvel Hôpital Civil, Strasbourg, France; 8Hôpital Sud, Amiens, France; 9CHU, Caen, France; 10Novartis Pharma S.A.S, Rueil-Malmaison, France; 11Keyrus Biopharma, Levallois-Perret, France; 12Hôpital Rangueil, Toulouse, France.

    Background: CERTITEM has evaluated the effect of everolimus/calcineurin inhibitors free (CNI free) on fibrosis progression and results have been reported at 12 months (M12). Data…
  • 2015 American Transplant Congress

    Calcineurin Inhibitors (CNI) Minimization Associated With Mammalian Target of Rapamycin Inhibitors (i-mTOR) to Improve Renal Function in Renal Grafts from Uncontrolled Donation After Cardiac Death Donors (UDCDD)

    M. Molina,1 E. Gutierrez,1 S. González-Sanchidrian,2 E. González,1 J. Cabrera,1 N. Polanco,1 A. Hernández,1 A. Sevillano,1 M. Praga,1 A. Andres.1

    1Nephrology, Hospital 12 de Octubre, Madrid, Spain; 2Nephrology, Hospital San Pedro de Alcántara, Caceres, Spain.

    INTRODUCTION: Ischemia injury in kidneys grafts from UDCDD could produce a poor renal function. Minimized blood levels of CNI associated with i-mTOR therapy could avoid…
  • 2015 American Transplant Congress

    Incidence of Hepatitis B Virus Reactivation in Kidney Transplant Patients Who Received Rituximab Administration

    K. Omoto, M. Okumi, D. Toki, T. Shimizu, H. Ishida, K. Tanabe.

    Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.

    OBJECTIVE:The efficacy of antiviral prophylaxis for rituximab (RIT)-associated hepatitis B virus (HBV) reactivation in patients with lymphoma has been recently reported. However, the immunological effect…
  • 2015 American Transplant Congress

    Efficacy and Safety of Three Different Treatment Regimen in De Novo Renal Transplant Patients: Month 48 Follow-Up Results of the HERAKLES Trial

    C. Sommerer,1 K. Budde,1 V. Kliem,1 O. Witzke,1 M. Guba,1 J. Jacobi,1 B. Vogt,3 I. Hauser,1 P. Reinke,1 R. Stahl,1 T. Rath,1 M. Porstner,2 D. Baeumer,2 M. Zeier,1 W. Arns,1 F. Lehner.1

    1Herakles Study Group, Germany; 2Novartis Pharma, Nuremberg, Germany; 3Herakles Study Group, Switzerland.

    Aim: To compare safety and efficacy of 3 different immunosuppressive (IS) regimen 4years after renal transplantation (Tx).Methods: 802 patients (pts) were included in this 1year,…
  • 2015 American Transplant Congress

    Clinical and Pathologic Predictors of Response to Belatacept Conversion

    S. Patel, H. Morris, D. Cohen, S. Mohan, L. Ratner, R. Crew.

    Columbia Universtiy, New York.

    INTRO: Calcineurin inhibitors have improved kidney transplant and recipient survival, their use has significant nephrotoxicity. Belatacept is a recently approved immunosuppressant that is not nephrotoxic…
  • 2015 American Transplant Congress

    Belatacept-Treated Patients Had Better Graft Survival at 7-Years Post-Transplant Compared With Cyclosporine-Treated Patients: Final Results from BENEFIT

    F. Vincenti,1 J. Grinyó,2 L. Rostaing,3 K. Rice,4 S. Steinberg,5 M. Moal,6 M. Polinsky,7 U. Meier-Kriesche,7 C. Larsen.8

    1Univ of Calif, San Francisco; 2Univ Hosp Bellvitge, Barcelona, Spain; 3Univ Hosp and INSERM U563,IFR-BMT, Toulouse, France; 4Baylor Univ Med Ctr, Dallas; 5Sharp Memorial Hosp, San Diego; 6Hôp de La Cavale Blanche, Brest, France; 7BMS, Lawrenceville; 8Emory Univ Transpl Ctr, Atlanta.

    Background: At 3yrs, improvement in renal function was seen in kidney transplant recipients treated with belatacept (bela) vs cyclosporine (CsA) in BENEFIT. Here we report…
  • 2015 American Transplant Congress

    Clinical Utility of Allospecific CD154+T-Cells in Children With Liver Or Intestine Transplantation (LTx, ITx)

    K. Soltys, G. Bond, G. Mazariegos, C. Ashokkumar, K. Dirling, L. O'Toole, P. Kachmar, T. Hartle, D. Martin, C. Trautz, R. Sindhi.

    Hillman Center for Pediatric Transplantation, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.

    Background: Allospecific CD154+T-cytotoxic memory (CD154+TcM) have completed investigational evaluation as predictors of acute cellular rejection in children with LTx or ITx.Purpose: To evaluate CD154+TcM** as…
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