Articles tagged "Immunosuppression"

2015 American Transplant Congress
Comparison of Efficacy and Renal Function in KidneyTransplant Recipients Receiving Tacrolimus (TAC)-Based Immunosuppressive Regimens in Combination With Everolimus (EVR) or Mycophenolate (MPA)
A. Ferreira,¹ C. Felipe,¹ P. Ueno,¹ P. Hannun,¹ P. Ruppel,¹ T. Sandes-Freitas,¹ H. Proença,³ J. Medina- Pestana,¹ H. Tedesco-Silva.¹
¹Nephrology, Hospital do Rim UNIFESP, Sao Paulo, Brazil; ²Pathology, UNIFESP, Sao Paulo, Brazil.
Introduction: Acute rejection and renal function are associated with long-term renal allograft survival. We evaluated these outcomes in patients receiving reduced TAC exposure combined with…
2015 American Transplant Congress
Pharmacokinetics of Mycophenolic Acid (MPA) in Elderly Compared to Young Recipients in the First Year After Renal Transplantation. Data from the NEverOLd Trial
P. Romano,¹ F. Agena,² P. Ebner,¹ A. Triboni,² F. Ramos,² N. Galante,² F. Lemos,² N. Sumita,¹ E. David-Neto.²
¹Division of Central Laboratory, – Hospital das Clinicas – University of São Paulo School of Medicine, Sao Paulo, Brazil; ²Renal Transplantation Service, – Hospital das Clinicas – University of São Paulo School of Medicine, Sao Paulo, Brazil.
Elderly (≥60years) recipients are nowadays receiving renal transplants more frequently. The pharmacokinetics studies (PK) of immunosuppressive drugs in healthy volunteers, rarely, if ever, include old…
2015 American Transplant Congress
Comparison of T Regulatory (Treg) Cell Function Pre- and Post-Lung Transplantation Shows a Major Negative Impact of Immunosuppression on Treg Function
T. Akimova,¹ J. Diamond,² D. Wilkes,³ D. Lederer,⁴ J. Christie,² W. Hancock.¹
¹Path & Lab Med, CHOP & UPenn, Philadelphia; ²Pulm, Allergy & Crit Care Med, UPenn, Philadelphia; ³Med, Microbiol & Immunol, Indiana Uni Sch of Med & Thoracic Transplant Prog, Indianapolis; ⁴Medicine, Columbia Uni, New York.
Aim: Clinical lung Tx recipients do not have sustained long-term survival outcomes comparable to that of other recipients of solid organ allografts, despite generally comparable…
2015 American Transplant Congress
Stable and Unstable Chimerism During Immunosuppressive Drug Withdrawal in Tolerant Recipients of HLA Matched Combined Kidney and Hematopoietic Cell Transplants
T. Pham,¹ S. Busque,¹ J. Scandling,² J. Shizuru,² S. Asha,¹ S. Strober.²
¹Surgery, Stanford University, Palo Alto, CA; ²Medicine, Stanford University, Palo Alto, CA.
Our previous studies showed that 75-80% of HLA matched recipients of combined kidney and hematopoietic cell transplants conditioned with total lymphoid irradiation (TLI) and anti-thymocyte…
2015 American Transplant Congress
Everolimus and Early Calcineurin Inhibitor Withdrawal Is Associated With Superior Renal Function: 5-Year Follow-Up of the Randomized PROTECT Liver Transplantation Study
M. Sterneck, G. Kaiser, N. Heyne, N. Richter, F. Rauchfuss, A. Pascher, P. Schemmer, L. Fischer, C. Klein, S. Nadalin, F. Lehner, U. Settmacher, D. Gotthardt, M. Loss, S. Ladenburger, P. Wimmer, M. Dworak, H. Schlitt.
PROTECT Study Group, Novartis Pharma GmbH, Germany.
Purpose: At the end of the 12-month (M) PROTECT core study (NCT00378014), de novo liver transplant recipients (LTxR) who switched from a calcineurin inhibitor (CNI)…
2015 American Transplant Congress
Proximal Tubular Dysfunction Is Common After the First Year of Kidney Transplantation
G. Ensergueix,¹ J. Allard,¹ F. Saint-Marcoux,² B. Marin,³ S. Bodeau,² J.-C. Aldigier,¹ P. Marquet,² M. Essig.¹
¹Nephrology, Dialysis, Transplantation, University Hospital, Limoges, France; ²Pharmacology, Toxicology, University Hospital, Limoges, France; ³Epidemiology, Biostatistics, Methodology, University Hospital, Limoges, France.
Background: After the initial period of kidney transplantation, the prevalence of proximal tubular dysfunction (PTD) and its consequences are unknown. The aim of this study…
2015 American Transplant Congress
Improved Renal Function Post-Liver Transplant With Earlier Everolimus Conversion
S. Lin,¹ M. Zimmerman,² V. Lewis,¹ S. Biggins,³ C. Ruller,⁴ I. Kam,⁴ T. Nydam.⁴
¹Pharmacy Dept, University of Colorado Hospital, Aurora; ²Division of Transplant Surgery, Medical College of Wisconsin, Wisconsin; ³Division of Gastroenterology/Hepatology, University of Colorado, Aurora; ⁴Division of Transplant Surgery, University of Colorado, Aurora.
Calcineurin inhibitors (CNI) play an important role in preventing acute rejection (AR) post-liver transplant. Its long-term use is limited by development of nephrotoxicity. Optimal timing…
2015 American Transplant Congress
The Effect of Compatibility of ABO Blood Type Antigens on Graft Survival of Intestinal Transplants
J. Cai,¹ A. Qing,² G. Wu,³ M. Everly,¹ P. Terasaki.¹
¹Terasaki Foundation Lab, Los Angeles; ²Lincoln High School, Stockton; ³The 4th Military Medical University, Xi-An, China.
Due to the introduction of new immunosuppressive agents and development of pre- and post-transplant patient management, ABO blood group incompatibility is no longer considered an…
2015 American Transplant Congress
Impacts of Mycophenolate Mofetile Addition to Very Low Exposure Everolimus and Calcineurine Inhibitor Based Immunosuppression in De Novo Kidney Transplantation
Y. Watarai,¹ M. Okada,¹ K. Futamura,¹ K. Ito,¹ T. Yamamoto,¹ M. Tsujita,¹ T. Hiramitsu,¹ N. Goto,¹ S. Narumi,¹ T. Kobayashi.²
¹Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan; ²Applied Immunity, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Purpose: Prospective randomized study of MMF addition to everolimus (EVR) based immunosuppression was evaluated in clinical outcomes as well as protocol biopsies findings and donor…
2015 American Transplant Congress
Costimulation Blockade Prevents Rejection of Vascularized Composite Allografts
B. Oh,¹ G. Furtmüller,¹ M. Fryer,¹ J. Grahammer,² S. Schneeberger,² D. Cooney,¹ W. Lee,¹ G. Brandacher.¹
¹Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; ²Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria.
[Background] Vascularized composite allotransplantation (VCA) is an emerging new era in transplant medicine and has become a valid therapeutic option after devastating tissue loss. The…