ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Immunosuppression"

  • 2015 American Transplant Congress

    Calcineurin (CNI) Exposure Reduces the Risk of Post-Transplant DSA After Deceased Donor Kidney Transplantation

    R. Pelletier, A. Rajab, G. Bumgardner, M. Henry.

    General Surgery, The Ohio State University, Columbus, OH.

    We use ATG induction with immediate rapamune (Rapa) and delayed CNI immunosuppression following kidney transplantation. Mycophenolic acid (MPA) is substituted for CNI to avoid renal…
  • 2015 American Transplant Congress

    Superior Renal Function in an Everolimus-Based Calcineurin Inhibitor Free Regimen Compared to Standard Cyclosporine/Mycophenolate and Low Cyclosporine/Everolimus: Follow-Up of the HERAKLES Study at Month 48

    K. Budde,1 C. Sommerer,1 P. Weithofer,1 O. Witzke,1 M. Guba,1 J. Jacobi,1 B. Vogt,3 I. Hauser,1 R. Stahl,1 P. Reinke,1 T. Rath,1 D. Baeumer,2 M. Porstner,2 M. Zeier,1 F. Lehner,1 W. Arns.1

    1Herakles Study Group, Germany; 2Novartis, Pharma, Germany; 3Herakles Study Group, Switzerland.

    Aim: To follow up on renal function (GFR) at month (Mo) 48 after kidney transplantation (Tx) in patients (pts) on immunosuppressive regimen with different calcineurin…
  • 2015 American Transplant Congress

    Long-Term Follow-Up After Conversion from Twice-Daily Tacrolimus Formulation to Once-Daily Tacrolimus Formulation in Pediatric Kidney Transplantation

    C. Choi, A. Han, S. Min, S.-K. Min, T. Lee, I.-M. Jung, S. Kim, J. Ha.

    Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea.

    PurposeTacrolimus is one of the most frequently used immunosuppressants in pediatric kidney transplantation (KT) as in adult. In Pediatric kidney recipients, it is more important…
  • 2015 American Transplant Congress

    Immunomodulatory Effects of Neuropilin-2 On T Cells

    H. Nakayama,1,2 N. Kochupurakkal,1 S. Bruneau,1 D. Bielenberg,2 M. Klagsbrun,2 D. Briscoe.1

    1Transplant Research Program, Boston Children's Hospital, Boston, MA; 2Vascular Biology Program, Boston Children's Hospital, Boston, MA.

    Axonal guidance molecules are expressed within the immune system and elicit anti-inflammatory effects with potential to target auto- and alloimmunity. The neuropilin (NRP) family receptors…
  • 2015 American Transplant Congress

    Risk Stratification in Tailoring Induction Therapy in Kidney Transplant Recipients(KTR): Is It Cost-Effective?

    B. Sirandas, A. Carlson, N. Kenyon, C. Truax, L. Smith.

    Transplant, Univ. of Utah, Salt Lake City, UT.

    Intro: Selecting induction therapy based on immunologic risk in KTR has gained popularity but there has yet to be a study evaluating the cost beyond…
  • 2015 American Transplant Congress

    Influence of Race on P-Glycoprotein Function in Peripheral Blood Mononuclear Cells

    K. Tornatore,1 H. Minderman,2 K. O'Loughlin,2 K. Attwood,3 D. Brazeau,4 R. Venuto.5

    1NYS Center of Excellence in Bioinformatics & Life Science, School of Pharmacy, Buffalo; 2Flow Cytometry Laboratories, Roswell Park Cancer Institute, Buffalo; 3Biostatistics, School of Public Health, Buffalo; 4University of New England; School of Pharmacy, Portland, ME; 5Medicine, School of Medicine; University at Buffalo, Buffalo, NY.

    Purpose: African Americans (AA) renal transplant recipients (RTR) have poorer long term allograft survival compared to Caucasians(C) which may be attributed to racial differences in…
  • 2015 American Transplant Congress

    Three Year Outcomes of Renal Allograft Transplants in African American Recipients Receiving Alemtuzumab for Induction Immunosuppression

    P. Vaitla, H. Bohorquez, A. Cohen, A. Cruz, U. Patel, S. Anders, C.-S. Catherine, A. Moiz, S. Guisti, I. Carmody, G. Loss, D. Bruce, T. Reichman, J. Garces.

    Ochsner Clinic Foundation, New Orleans, LA.

    Background:Induction with Alemtuzumab is well documented to reduce the incidence and severity of acute rejection episodes, which may improve graft survival. Limited data are available…
  • 2015 American Transplant Congress

    Primary and Secondary Vaccine Responses in a Non-Human Primate Model of Cardiac Allotransplantation

    S. Dahi,1 E. Kang,1 T. Zhang,1 B. Vanhove,2 A. Azimzadeh,1 R. Pierson III.1

    1Department of Surgery, University of Maryland School of Medicine, Baltimore, MD; 2INSERM, Nantes, France.

    Purpose: To compare the effect of calcineurin- versus costimulation-based immunosuppression on primary and secondary vaccine responses in non-human primate heart transplant recipients.Background: Antibody response following…
  • 2015 American Transplant Congress

    Evaluating the Benefits of Everolimus on Cardiac Allograft Vasculopathy: Further Evidence from Results of Imputations for Missing IVUS Data from A2310 Study

    P. Lopez,1 G. Dong,2 Z. Wang.2

    1Novartis Pharma AG, Basel, Switzerland; 2Novartis Pharmaceuticals, East Hanover, NJ; 3Novartis Pharmaceuticals, East Hanover, NJ.

    Purpose: A2310 IVUS study showed that everolimus (EVR) provides cardiac allograft vasculopathy (CAV) benefit compared to mycophenolate mofetil (MMF) by assessing the mean change in…
  • 2015 American Transplant Congress

    Transplantation of Kidneys from Donors With Acute Renal Failure: Five-Year Results from Double Center Experience

    C. Ramirez,1,2 A. Safra,1 A. Shah,1,2 C. Doria,1 W. Maley,1 A. Frank,1 C. Gorn,1 L. Lerner.2

    1Department of Surgery, Division of Transplantation, Thomas Jefferson University Hospital, Philadelphia, PA; 2Department of Kidney Transplantation, Lankenau Medical Center, Wynnewood, PA.

    Background: Transplantation of kidneys from deceased donors with acute renal failure (ARF) has been described and represents an underutilized source of renal grafts. We reviewed…
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