Articles tagged "Immunosuppression"

2015 American Transplant Congress
Post-Kidney Transplant Infections in Desensitized Patients Receiving Thymoglobulin or Daclizumab Induction: Results of a Randomized Clinical Trial
B. Orandi,¹ J. Locke,² E. Kraus,³ B. Lonze,¹ N. Desai,¹ N. Dagher,¹ N. Alachkar,³ C. Simpkins,⁴ F. Naqvi,³ D. Segev,¹ R. Montgomery,¹ R. Avery.³
¹Department of Surgery, Johns Hopkins University, Baltimore; ²Department of Surgery, University of Alabama--Birmingham, Birmingham; ³Department of Medicine, Johns Hopkins University, Baltimore; ⁴Department of Surgery, Dartmouth, Lebanon.
Live donor kidney transplant recipients requiring desensitization for donor-specific antibody, who were enrolled in a single-center randomized trial of thymoglobulin vs. daclizumab induction, were evaluated…
2015 American Transplant Congress
Evaluation of Donor-Specific Antibodies Through 7 Years With Belatacept in BENEFIT and BENEFIT-EXT
R. Bray,¹ H. Gebel,¹ R. Townsend,² U. Meier-Kriesche,² C. Larsen.¹
¹Emory University, Atlanta; ²Bristol-Myers Squibb, Lawrenceville.
Purpose: The development of donor-specific antibody (DSA) is linked to an increased risk of antibody-mediated rejection and graft failure. The 3 year intent-to-treat results from…
2015 American Transplant Congress
Impact of Human Mutant TGF-β1/Fc Protein On Memory and Regulatory CD4+T Cells Following Lymphodepletion in Rhesus Monkeys
H. Guo,¹ L. Lu,¹ R. Wang,² H. Abdulkerim,² R. Keith,² A. Thomson,¹ M. Ezzelarab.¹
¹Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA; ²MassBiologics, University of Massachusetts Medical School, Boston, MA.
Background:Tolerance to allografts is essential to avoid chronic immunosuppression and to promote long term graft function. Transforming growth factor- β plays a key role in…
2015 American Transplant Congress
Effect of Everolimus on Cardiovascular Parameters in De Novo Kidney Transplant Recipients: 12-Month Results from the ELEVATE Study
H. Holdaas,¹ M. van der Giet,¹ J. de Fijter,¹ A. Speziale,² C. Escrig,² G. Junge,² Z. Wang,³ J. Cruzado.¹
¹For the ELEVATE Study, Oslo, Norway; ²Novartis, Basel, Switzerland; ³Novartis Corporation, East Hanover, NJ.
Background: Long-term exposure to calcineurin inhibitors (CNIs) contributes to an unfavorable cardiovascular (CV) risk profile, including inferior renal allograft function and premature graft loss with…
2015 American Transplant Congress
Anti-CD122 + Costimulation Blockade Prolongs Allograft Survival
D. Mathews,¹ L. Higginbotham,¹ Y. Dong,¹ C. Breeden,¹ C. Larsen,¹ J. Tso,² A. Adams.¹
¹Emory Transplant Center, Emory University, Atlanta, GA; ²JN Bioscience, Mountanview, CA.
Introduction: Effective T cell activation and effector function requires (1) cognate antigen recognition (2) appropriate costimulation and (3) successful cytokine signaling. Recently approved strategies to…
2015 American Transplant Congress
Diverticulitis in Immunosuppressed Patients – A Fatal Outcome Requiring a New Approach?
A. Brandl, T. Kratzer, E. Braunwarth, S. Weiss, M. Maglione, S. Schneeberger, R. Kafka-Ritsch.
Visceral, Transplant and Thoracic Surgery, Medical University, Innsbruck, Austria.
PurposeThe purpose of this study was to evaluate in-hospital mortality and morbidity associated with diverticulitis in immunosuppressed patients compared to non-immunosuppressed patients, and to identify…
2015 American Transplant Congress
Analysis of Causes of Graft Loss Among Kidney Transplant Patients Receiving Tacrolimus Vs Cyclosporine
M. Kamel,¹ M. Posadas Salas,¹ D. Taber,² M. Kadian,¹ M. Salazar,¹ P. Mohan,¹ T. Srinivas.¹
¹Department of Medicine, Medical University of South Carolina, Charleston, SC; ²Department of Surgery, Medical University of South Carolina, Charleston, SC.
Tacrolimus (FK) has surpassed cyclosporine (CYA) as the calcineurin inhibitor (CNI) of choice for the vast majority of kidney transplant (KTX) programs. Yet, CYA continues…
2015 American Transplant Congress
Belatacept in a Community Hospital Adult Kidney Transplant Program
D. Nikolaenko, Q. Chaudhry, H. Smith, C. Shadur.
Iowa Methodist Medical Center, Des Moines, IA.
PURPOSE:This is a retrospective look (08/2011-11/2014) on data collected from patients transplanted at Iowa Methodist Transplant Center.METHODS:All patients were EBV positive. They were induced with…
2015 American Transplant Congress
Eomesodermin Expression By Alloreactive Non-Human Primate CD8+ Memory T Cells: Influence of CTLA4Ig and Regulatory DC Infusion in Renal Allograft Recipients
M. Ezzelarab,¹ L. Lu,¹ H. Guo,¹ A. Zahorchak,¹ W. Shufesky,¹ D. Cooper,¹ A. Morelli,^1,2 A. Thomson.^1,2
¹Surgery - Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA; ²Immunology, University of Pittsburgh, Pittsburgh, PA.
Background:Memory T cells (Tmem), particularly those resistant to costimulation blockade (CoSB), are considered a major barrier to transplant tolerance. The T-box transcription factor Eomesodermin (Eomes)…
2015 American Transplant Congress
The Influence of Immunosuppressive Drugs On the Epithelial Microenvironment in Solid Organ Transplantation – Identification of Biomarker Candidates for Rejection Vs. Tolerance
A. Akhdar,¹ B. Mueller,² C. Neudoerfl,¹ F. Lehner,³ M. Stevanovic-Meyer,¹ K. Daemen,¹ J. Keil,¹ H. Haller,⁴ C. Blume,^4,5 C. Falk.^1,6
¹Institute of Transplant Immunology, IFB-Tx, Hanover Medical School, Hanover, Germany; ²MorphoSys, Munich, Germany; ³Department of General, Visceral and Transplantation Surgery, Hanover Medical School, Hanover, Germany; ⁴Department of Nephrology and Hypertension, Hanover Medical School, Hanover, Germany; ⁵Institute of Technical Chemistry, Leibniz University Hanover, Hanover, Germany; ⁶German Center for Infection Research, Braunschweig, Germany.
In the context of kidney transplantation, NK cells may play an important role by targeting the allogeneic organ due to "missing-self recognition", which leads to…