Articles tagged "Immunosuppression"

2016 American Transplant Congress
Association of Smoking Habits with Comorbidity 15 Years After Liver Transplantation.
S. Pischke,³ M. Lege,¹ L. Fischer,² U. Herden,² A. Lohse,³ B. Nashan,² M. Sterneck.¹
¹University Transplant Center, University Hospital Hamburg Eppendorf, Hamburg, Germany; ²Department of Hepatobiliary Surgery and Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany; ³Department of Medicine, University Hospital Hamburg Eppendorf, Hamburg, Germany.
Background and aimsThe survival rate of liver transplant (OLT) recipients has strongly improved over the last years. Here we investigate the association between long term…
2016 American Transplant Congress
First Bilateral Hand Transplant in a Child: Short-Term Medical Outcomes and Challenges.
S. Amaral,¹ M. Levine,² B. Chang,² S. Lopez,¹ C. McAndrew,² S. Kessler,¹ A. Shaked,² L. Levin.²
¹Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA; ²Surgery, University of Pennsylvania, Philadelphia, PA.
Background: In July 2015, our center successfully performed the first bilateral hand transplant in a pediatric patient in the United States. The recipient was an…
2016 American Transplant Congress
Early Conversion to Everolimus in De Novo Renal Transplant Recipients: Incidence of Viral Infections in the Randomized-Controlled ELEVATE Study.
H. Hirsch,¹ J. De Fijter,¹ M. van der Giet,¹ M. Zeier,¹ J. Pascual,¹ Y. Avihingsanon,¹ P. Lopez,² J. Aguilar-Sanchez,² J. Kochuparampil,² Z. Wang,³ H. Holdaas,¹ J. Cruzado.¹
¹ELEVATE Study Group, Basel, Switzerland; ²Novartis, Basel, Switzerland; ³Novartis Pharmaceutical Corporation, East Hanover.
BackgroundCytomegalovirus (CMV) and BK polyomavirus (BKPyV) infections are independent risk factors for acute rejection and graft loss. Early conversion from calcineurin inhibitors (CNIs) to everolimus…
2016 American Transplant Congress
Everolimus versus Mycophenolate Mofetil in Combination with Tacrolimus: A Propensity Score Matching Analysis in Liver Transplantation.
P. de Simone,¹ P. Carrai,¹ A. Precisi,² L. Coletti,¹ D. Ghinolfi,¹ F. Filipponi.¹
¹Hepatobiliary Surgery and Liver Transplantation, University of Pisa Medical School Hospitals, Pisa, Italy; ²Laboratory, University of Pisa Medical School Hospital, Pisa, Italy.
Background: No trial has so far investigated everolimus (EVR)-incorporating immunosuppressive regimens versus combined use of tacrolimus (TAC) and mycophenolate mofetil (MMF) in liver transplantation (LT).Materials…
2015 American Transplant Congress
Variables Related to the Development of Donor Specific Antibodies (DSA) Post-Kidney Transplant (KTx): Implications for Late Graft Histology and Survival
F. Cosio,¹ C. Schinstock,¹ M. Stegall.²
¹Medicine, Mayo Clinic, Rochester, MN; ²Surgery, Mayo Clinic, Rochester, MN.
Introduction. The incidence of de novo DSA increases post-KTx. DSA is associated to reduced graft survival likely due to chronic antibody mediated rejection (cAMR). However,…
2015 American Transplant Congress
Reduced Incidence of Cytomegalovirus Infection in Kidney Transplant Recipients Receiving Everolimus
H. Tedesco-Silva,¹ C. Felipe,¹ A. Ferreira,¹ M. Cristelli,¹ T. Sandes- Freitas,¹ N. Oliveira,¹ W. Aguiar,² G. Bassos,¹ M. Franco,³ M. Gerbase- Lima,⁴ E. Campos,⁴ J. Medina-Pestana.¹
¹Nephrology, Hospital do Rim UNIFESP, Sao Paulo, Brazil; ²Urology, Hospital do Rim UNIFESP, Sao Paulo, Brazil; ³Pathology, UNIFESP, Sao Paulo, Brazil; ⁴Immunogenetic, AFIP, Sao Paulo, Brazil.
BACKGROUND: CMV infection is associated with inferior long-term kidney transplant outcomes. This study compared the incidence of CMV infection/disease in de novo kidney transplant recipients…
2015 American Transplant Congress
IL-21 Regulates Creation of Tertiary Lymphoid Organs in Chronic Allograft Rejection
C. Baum,¹ M. Khattar,² P. Schroder,¹ W. Chen,³ S. Stepkowski.¹
¹Medical Microbiology and Immunology, University of Toledo College of Medicine, Toledo, OH; ²Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA; ³Transplant Immunology Research Program, Houston Methodist Research Institute, Houston, TX.
BACKGROUND: IL-21 is a cytokine expressed almost exclusively by cells of the adaptive immune system. This makes it an attractive target for reducing chronic allograft…
2015 American Transplant Congress
Not Only CD28null But Also CD28pos T Cells Contribute to Rejection During Belatacept Treatment
G. de Graav,¹ D. Hesselink,¹ R. Kraaijeveld,¹ M. Dieterich,¹ W. Weimar,¹ M. Clahsen-Van Groningen,² C. Baan.¹
¹Internal Medicine, Erasmus Medical Center, Rotterdam, South Holland, Netherlands; ²Pathology, Erasmus Medical Center, Rotterdam, South Holland, Netherlands.
To explain the underlying immunological mechanisms for rejection under belatacept treatment, the phenotypical and functional characteristics of graft infiltrating lymphocytes were studied during rejection under…
2015 American Transplant Congress
Everolimus-Based Immunosuppression Is Associated With a Reduced Risk of New-Onset Malignancies After Liver Transplantation
P. De Simone,¹ P. Carrai,¹ L. Coletti,¹ D. Ghinolfi,¹ D. Campani,² F. Filipponi.¹
¹Hepatobiliary Surgery and Liver Transplantation, University of Pisa Medical School Hospital, Pisa, Italy; ²Pathology, University of Pisa Medical School Hospital, Pisa, Italy.
Background and aim: The inhibitor of the mammalian target of rapamycin (mTOR) everolimus (EVR) has shown anti-proliferative effects in experimental and clinical models. We investigated…
2015 American Transplant Congress
Aging Enhances Immunosuppressives Capacities of Tacrolimus By Functional Changes of CD4+ T-Cells
F. Krenzien,¹ M. Quante,¹ A. ElKhal,¹ H. Uehara,¹ R. Abdi,² B. Slegtenhorst,¹ H. Biefer,¹ S. Tullius.¹
¹Transplant Surgery Research Laboratory and Division of Transplant Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; ²Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Immunosenescence has broad consequences on alloimmunity and immunosuppression in the elderly may require age-adaptation. Here, we investigated the influence of aging on the effectivity of…