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Articles tagged "Immunosuppression"

  • 2016 American Transplant Congress

    Evaluation of Patient-Reported Nonadherence with Tacrolimus Level Variability in Renal Transplant Recipients.

    N. Parrish,1 T. Kaiser,2 A. McCann,1 J. Aladimi,2 J. Harris,3 A. Govil,2 B. Abu Jawdeh,2 G. Mogilishetty,2 R. Alloway,2 E. Woodle.2

    1Pharmacy Services, University of Cincinnati Medical Center, Cincinnati, OH; 2Medicine, University of Cincinnati, Cincinnati, OH; 3Transplant, University of Cincinnati Medical Center, Cincinnati, OH.

    Medication nonadherence (NA) continues to be a major cause of graft loss post-transplant. Several methods for prospective adherence monitoring have been described including patient interview…
  • 2016 American Transplant Congress

    Predictive Model for Medication Errors in a Chronic Kidney Transplant Clinic.

    K. Covert,1 C. Mardis,1 J. Fleming,1 A. Mardis,1 H. Meadows,1 N. Pilch,1 P. Mohan,2 M. Posadas,2 M. Salazar,2 T. Srinivas,2 G. Mour,2 D. Taber.1

    1Pharmacy, The Medical University of South Carolina, Charleston, SC; 2Transplant Nephrology, The Medical University of South Carolina, Charleston, SC.

    Medication errors are associated with increased incidence of infection, rejection, and graft loss in kidney transplant recipients. This study aims to create a model to…
  • 2016 American Transplant Congress

    Impact of Low Dose Tacrolimus with Everolimus Regimen on Renal Pathology and T-Regulatory Cells in Kidney Transplant.

    A. Shetty,1 T. Opas,1 J. Mathew,1 V. Mas,2 J. Leventhal,1 N. Sustento-Reodica,1 L. Gallon.1

    1Northwestern University, Feinberg School of Medicine, Chicago, IL; 2University of Virginia, Charlottesville, VA.

    Calcineurin inhibitors (CNI) serve as the cornerstone of immunosuppression (IS) after kidney transplant. However chronic CNI nephrotoxicity has been implicated in allograft dysfunction. We hypothesize…
  • 2016 American Transplant Congress

    Increasing Tacrolimus Time-in-Therapeutic Range Is Associated with Less Cellular Rejection in Lung Transplant Recipients.

    C. Ensor, K. Harrigan, R. Venkataramanan, M. Morrell, C. Moore, J. Hayanga, M. Crespo, J. DCunha, A. Zeevi, J. McDyer.

    University of Pittsburgh, Pittsburgh, PA.

    Purpose: To describe the effect of tacrolimus (FK) time-in-therapeutic range (TTR) on incidence of cellular rejection (ACR) within the first year after lung transplantation (LT).Methods:…
  • 2015 American Transplant Congress

    Immunomodulatory Effects of Neuropilin-2 On T Cells

    H. Nakayama,1,2 N. Kochupurakkal,1 S. Bruneau,1 D. Bielenberg,2 M. Klagsbrun,2 D. Briscoe.1

    1Transplant Research Program, Boston Children's Hospital, Boston, MA; 2Vascular Biology Program, Boston Children's Hospital, Boston, MA.

    Axonal guidance molecules are expressed within the immune system and elicit anti-inflammatory effects with potential to target auto- and alloimmunity. The neuropilin (NRP) family receptors…
  • 2015 American Transplant Congress

    Risk Stratification in Tailoring Induction Therapy in Kidney Transplant Recipients(KTR): Is It Cost-Effective?

    B. Sirandas, A. Carlson, N. Kenyon, C. Truax, L. Smith.

    Transplant, Univ. of Utah, Salt Lake City, UT.

    Intro: Selecting induction therapy based on immunologic risk in KTR has gained popularity but there has yet to be a study evaluating the cost beyond…
  • 2015 American Transplant Congress

    Influence of Race on P-Glycoprotein Function in Peripheral Blood Mononuclear Cells

    K. Tornatore,1 H. Minderman,2 K. O'Loughlin,2 K. Attwood,3 D. Brazeau,4 R. Venuto.5

    1NYS Center of Excellence in Bioinformatics & Life Science, School of Pharmacy, Buffalo; 2Flow Cytometry Laboratories, Roswell Park Cancer Institute, Buffalo; 3Biostatistics, School of Public Health, Buffalo; 4University of New England; School of Pharmacy, Portland, ME; 5Medicine, School of Medicine; University at Buffalo, Buffalo, NY.

    Purpose: African Americans (AA) renal transplant recipients (RTR) have poorer long term allograft survival compared to Caucasians(C) which may be attributed to racial differences in…
  • 2015 American Transplant Congress

    Three Year Outcomes of Renal Allograft Transplants in African American Recipients Receiving Alemtuzumab for Induction Immunosuppression

    P. Vaitla, H. Bohorquez, A. Cohen, A. Cruz, U. Patel, S. Anders, C.-S. Catherine, A. Moiz, S. Guisti, I. Carmody, G. Loss, D. Bruce, T. Reichman, J. Garces.

    Ochsner Clinic Foundation, New Orleans, LA.

    Background:Induction with Alemtuzumab is well documented to reduce the incidence and severity of acute rejection episodes, which may improve graft survival. Limited data are available…
  • 2015 American Transplant Congress

    Primary and Secondary Vaccine Responses in a Non-Human Primate Model of Cardiac Allotransplantation

    S. Dahi,1 E. Kang,1 T. Zhang,1 B. Vanhove,2 A. Azimzadeh,1 R. Pierson III.1

    1Department of Surgery, University of Maryland School of Medicine, Baltimore, MD; 2INSERM, Nantes, France.

    Purpose: To compare the effect of calcineurin- versus costimulation-based immunosuppression on primary and secondary vaccine responses in non-human primate heart transplant recipients.Background: Antibody response following…
  • 2015 American Transplant Congress

    Evaluating the Benefits of Everolimus on Cardiac Allograft Vasculopathy: Further Evidence from Results of Imputations for Missing IVUS Data from A2310 Study

    P. Lopez,1 G. Dong,2 Z. Wang.2

    1Novartis Pharma AG, Basel, Switzerland; 2Novartis Pharmaceuticals, East Hanover, NJ; 3Novartis Pharmaceuticals, East Hanover, NJ.

    Purpose: A2310 IVUS study showed that everolimus (EVR) provides cardiac allograft vasculopathy (CAV) benefit compared to mycophenolate mofetil (MMF) by assessing the mean change in…
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