2015 American Transplant Congress
Living and Dead Mesenchymal Stem Cells Induce an Immunosuppressive Response in an Experimental Sepsis Model
There is evolving interest in the use of mesenchymal stem cells (MSC) as a cell therapeutic agent after solid organ transplantation. The nature of the…2015 American Transplant Congress
Changes in Immunophenotypes After Conversion from Calcineurin Inhibitors to mTOR Inhibitors in Renal Transplant Recipients
Chronic toxicity of calcineurin inhibitors (CNI) is one of the major causes of chronic allograft loss. Conversion from CNI to mTOR ((mammalian target of rapamycin)…2015 American Transplant Congress
A Cross-Organ Tissue Gene Expression Immune Signature Predates Chronicity
Transplantation Surgery, UC San Francisco, San Francisco, CA.
Purpose Meta-analysis of 796 microarrays led to the discovery of 11 over-expressed genes (BASP1, CD6, CXCL9, CXCL10, INPP5D, ISG20, LCK, NKG7, PSMB9, RUNX3, and TAP1)…2015 American Transplant Congress
Rejection Triggers Liver Transplant Tolerance: Involvement of Mesenchyma-Meidated Immune Control Mechanisms
Successful organ transplantation relies on lifelong immunosuppression, associated with severe side effects. Induction of tolerance is ideal but elusive in clinic. Indeed spontaneous liver transplant…2015 American Transplant Congress
Hepatic Stellate Cells Directly Inhibit B Cells Via PD-L1
Hepatic stellate cells (HSCs) account for one third of the nonparenchymal cells in the liver, which are considered to be critical in maintaining the immunoprivileged…2015 American Transplant Congress
miRNA-181 Promotes Graft Prolongation by Plasmacytoid Dendritic Cells By Increasing T Regulatory Cells and Decreasing B Cells as Revealed By Cytometry By Time-Of-Flight
1Surgery, Stanford University, Stanford, CA; 2Pediatrics, UCSF, San Francisco, CA.
Liver allografts are well tolerated and other solid organ allografts, when transplanted concurrently with livers, show improved outcomes. However, the mechanisms underlying “hepatic tolerance” have…2015 American Transplant Congress
Renal Dysfunction by BK Virus Infection Is Correlated With Activated T Cell Level, Cytokines Level, Gramzymes in Renal Transplantation
Purpose:BK virus (BKV) is known to be associated with nephropathy (BKAN). Here, we investigated the relationships between BKV levels, T-cell activation, cytokines and kidney function…
American Transplant Congress abstracts