Articles tagged "Hyperglycemia"

2019 American Transplant Congress
Prevention of Diabetes in the NOD Mice Reconstituted with Bone Marrow Cells from Allogeneic CD4 Knockout, CD8 Knockout or B-Cell Knockout B6 Mice
Y. Huang, H. Xu, Y. Wen, S. Ildstad
University of Louisville, Louisville, KY
*Purpose: Type 1 diabetes (T1D) is an autoimmune disorder characterized by destruction of the pancreatic beta cells by both humoral- and cell-mediated immune mechanisms. Transplantation…
2019 American Transplant Congress
Prevention of Islet Allo- and Xenograft Rejection with Immunoglobulin M Immunotherapy
M. Ma, P. Chhabra, K. Brayman
Surgery, University of Virginia, Charlottesville, VA
*Purpose: To investigate if IgM therapy mitigates islet allo- and xenotransplant rejection and promotes permanent islet survival.*Methods: 1) New onset diabetic NOD mice (n=14) were…
2019 American Transplant Congress
FK506 Influence Glucose Metabolism by Short Chain Fatty Acid
W. Jiao¹, Z. Zhang¹, L. Liu², X. Hu¹
¹Urology, Capital Medical University Beijing Chaoyang Hospital, Beijing, China, ²GI Divison, West China Hospital, Beijing, China
*Purpose: FK506 is one of the most common immunosuppressant drugs in organ transplantation, which have been demonstrated to cause glucose metabolism disorder and alterd the…
2019 American Transplant Congress
Belatacept Based Simultaneous Calcineurin Inhibitor Avoidance/Early Corticosteroid Withdrawal is Associated with Low New Onset Diabetes Risk
A. R. Shields¹, P. West-Thielke², E. S. Woodle¹, D. B. Kaufman³, J. Lipscomb⁴, J. P. Leone⁵, A. Wiseman⁶, E. King⁴, A. J. Matas⁷, R. R. Alloway for the BEST Study Group⁴
¹Transplant Surgery, U of Cincinnati, Cincinnati, OH, ²UIC, Chicago, IL, ³Transplant Surgery, U of Wisconsin, Madison, WI, ⁴U of Cincinnati, Cincinnati, OH, ⁵Tampa General, Tampa, FL, ⁶U of Colorado, Denver, CO, ⁷U Minnesota, Minneapolis, MN
*Purpose: Calcineurin inhibitor (CNI) and/or corticosteroid (CCS) therapy are associated with significant risk of new onset diabetes after transplantation (NODAT). An important consideration for simultaneous…
2019 American Transplant Congress
The Impact of Sleeve Gastrectomy Following Liver Transplant in Patients with Non-Alcoholic Steatosis: A Five-Year Experience
M. C. Morris¹, A. D. Jung¹, Y. Kim¹, V. K. Dhar¹, S. Shah¹, D. Schauer², E. Smith², T. Diwan¹
¹Surgery, University of Cincinnati, Cincinnati, OH, ²Medicine, University of Cincinnati, Cincinnati, OH
*Purpose: Non-alcoholic steatohepatitis (NASH) cirrhosis is an increasingly common indication for liver transplantation (LT) in the United States and obese patients continue to be at…
2019 American Transplant Congress
Blood Group Incompatible Living Donor Kidney Transplantation in Patients with End-Stage Kidney Disease Due to Diabetes Kidney Disease
J. Uchida¹, A. Kosoku¹, K. Kabei¹, S. Nishide¹, H. Shimada¹, K. Maeda², Y. Yoshikawa³, T. Iwai¹, N. Kuwabara¹, T. Naganuma¹, N. Kumada⁴, Y. Takemoto¹, T. Nakatani¹
¹Urology, Osaka City University Graduate School of Medicine, Osaka, Japan, ²Nursing, Osaka City University Hospital, Osaka, Japan, ³Osaka City University, Osaka, Japan, ⁴Urology, Suita Municipal Hospital, Suita, Japan
*Purpose: Diabetes is a growing public health problem, and diabetes kidney disease (DKD) is the most prevalent chronic kidney disease and the major cause of…
2019 American Transplant Congress
HbA1c as a Noninvasive Predictor of Chronic Histopathologic Changes in Living Donors for Kidney Transplantation
K. Tanaka¹, S. Nishida¹, K. Kinoshita¹, Y. Hidaka¹, M. Toyoda², A. Inadome³, A. Takeda⁴, H. Yokomizo⁵, S. Uekihara⁶, J. Shoji⁷, S. Yamanaga¹
¹Surgery, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan, ²general medicine, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan, ³Urology, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan, ⁴Nephrology, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Japan, ⁵Surgery, Japanese Red Cross Kumamoto Hospital, kumamoto, Japan, ⁶general medicine, Japanese Red Cross Kumamoto Hospital, kumamoto, Japan, ⁷Nephrology, UCSF Connie Frank Transplant Center, San francisco, CA
*Purpose: The degree of chronic histopathologic changes in renal allografts, including interstitial fibrosis, tubular atrophy, and arteriolar hyalinosis, can have clinical implications in long-term allograft…
2019 American Transplant Congress
Impact of Hepatitis C Viremia on Post-Transplant Diabetes Mellitus Development in Liver Transplant Recipients
K. Klein¹, J. Nelson², B. Crowther¹, C. Guerra³, E. Kincaide¹, K. V. Speeg⁴, N. Alkhouri⁵, R. Hall¹
¹University Health System, The University of Texas at Austin, College of Pharmacy, Pharmacotherapy Division, Austin, TX, The University of Texas Health Science Center at San Antonio, San Antonio, TX, ²University Health System, San Antonio, TX, ³The University of Texas Health Science Center at San Antonio, University of the Incarnate Word Feik School of Pharmacy, San Antonio, TX, ⁴University Health System, The University of Texas Health Science Center at San Antonio, San Antonio, TX, ⁵University Health System, The University of Texas Health Science Center at San Antonio, Texas Liver Institute, San Antonio, TX
*Purpose: Compare incidence of post-transplant diabetes mellitus (PTDM) in hepatitis C virus (HCV) patients with and without viremia at the time of orthotopic liver transplantation…
2018 American Transplant Congress
Hyperglycemia Aggravates Hepatic Ischemia and Reperfusion Injury by Inhibiting Liver Resident Macrophage M2 Polarization via C/EBP-Homologous Protein-Mediated Endoplasmic Reticulum Stress
Z. Rao, J. Sun, X. Pan, Z. Chen, H. Sun, P. Zhang, M. Gao, Z. Ding, C. Liu.
Anesthesiology, First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Background:Aggravated liver ischemia and reperfusion (IR) injury has been observed in hyperglycemic hosts, but its underlying mechanism remains undefined. The aim of the study was…
2018 American Transplant Congress
The Price of Diabetes Medication Management in Kidney Transplantation: Similar Rates of Readmissions, but More Healthcare Utilization
J. Hardcopf, H. Meadows, N. Pilch, C. Perez, N. Patel, J. Fleming, H. Corbo, T. Harrison, B. O'Brien, D. DuBay, D. Taber.
Medical University of South Carolina, Charleston, SC.
Background: The aim of this study was to determine whether changing diabetes (DM) medications during the index admission for kidney transplant (KT) is significantly associated…