2019 American Transplant Congress
Hyperglycemia Aggravates Acute Liver Injury by Promoting Macrophage NLRP3 Activation via AMPK/mTOR-Dependent Autophagy Inhibition
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: The detrimental effects of diabetes mellitus/hyperglycemia include an increase in the oxidative stress response and an enhanced inflammatory response. Despite an increased understanding of…2019 American Transplant Congress
Inpatient versus Outpatient Management of Hyperglycemia in Post-Transplant Patients Following High Dose Steroid Pulses for Acute Rejection
1University of Connecticut, School of Pharmacy, Storrs, CT, 2Yale New Haven Hospital, New Haven, CT
*Purpose: Acute cellular rejection (ACR) occurs in approximately ten percent of all transplant patients and is typically treated with multiple infusions of high-dose steroids (HDS).…2019 American Transplant Congress
Use of GLP-1 Receptor Agonists in Kidney Transplant Recipients with Type 2 Diabetes
*Purpose: GLP-1 receptor agonists have been shown to improve glucose control and diabetes-related comorbidities, including obesity, cardiovascular disease and chronic kidney disease, in non-transplant patients.…2019 American Transplant Congress
Pharmacist-Led Management of Post-Transplant Hyperglycemia Reduces Hospitalizations
*Purpose: Renal transplant recipients (RTRs) are at risk of developing post-transplant hyperglycemia (PTHG), defined as blood glucose > 180 mg/dL within the first 45 days…2019 American Transplant Congress
Insulin Resistance as a Surrogate Marker for Post-Transplantation Diabetes Mellitus
Department of Medicine, Division of Nephrology, Federal University of São Paulo, São Paulo, Brazil
*Purpose: Post-transplantation diabetes mellitus (PTDM) adversely impact patient and kidney allograft survival. Further knowledge of the risk factors involved in the onset and progression of…2019 American Transplant Congress
Prevalence of Diabetes after Transplant in a Single Center
*Purpose: The investigators aim to study the prevalence of post kidney transplant diabetes (NODAT) in a single Asian pediatric centre and to identify clinical factors…2019 American Transplant Congress
Prevention of Diabetes in the NOD Mice Reconstituted with Bone Marrow Cells from Allogeneic CD4 Knockout, CD8 Knockout or B-Cell Knockout B6 Mice
University of Louisville, Louisville, KY
*Purpose: Type 1 diabetes (T1D) is an autoimmune disorder characterized by destruction of the pancreatic beta cells by both humoral- and cell-mediated immune mechanisms. Transplantation…2019 American Transplant Congress
Prevention of Islet Allo- and Xenograft Rejection with Immunoglobulin M Immunotherapy
Surgery, University of Virginia, Charlottesville, VA
*Purpose: To investigate if IgM therapy mitigates islet allo- and xenotransplant rejection and promotes permanent islet survival.*Methods: 1) New onset diabetic NOD mice (n=14) were…2018 American Transplant Congress
Hyperglycemia Aggravates Hepatic Ischemia and Reperfusion Injury by Inhibiting Liver Resident Macrophage M2 Polarization via C/EBP-Homologous Protein-Mediated Endoplasmic Reticulum Stress
Anesthesiology, First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Background:Aggravated liver ischemia and reperfusion (IR) injury has been observed in hyperglycemic hosts, but its underlying mechanism remains undefined. The aim of the study was…2018 American Transplant Congress
The Price of Diabetes Medication Management in Kidney Transplantation: Similar Rates of Readmissions, but More Healthcare Utilization
Medical University of South Carolina, Charleston, SC.
Background: The aim of this study was to determine whether changing diabetes (DM) medications during the index admission for kidney transplant (KT) is significantly associated…
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