ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "HLA matching"

  • 2019 American Transplant Congress

    Impact of Induction Choice and Early Steroid Withdrawal on Outcomes in HLA Zero Mismatched Kidney Transplant Recipients

    C. Votruba1, K. Holdener1, B. Astor2, F. Aziz2, D. Mandelbrot2

    1Pharmacy, University of Wisconsin Hospitals and Clinics, Madison, WI, 2Nephrology, University of Wisconsin Hospitals and Clinics, Madison, WI

    *Purpose: Ideal induction and immunosuppression therapy for 6-antigen HLA matched deceased and living kidney transplant recipients (KTR) is not well understood.*Methods: All 6-antigen HLA matched…
  • 2019 American Transplant Congress

    Impact of HLA-DR Matching on HLA-DQ Matching Status and the Development of Anti-HLA-DQ De Novo DSA under Calcineurin Inhibitor or Belatacept Immunosuppression

    V. Jucaud1, H. Gebel2, R. Bray2, M. Polinsky3, M. Everly1

    1Terasaki Research Institute, Los Angeles, CA, 2Emory University, Atlanta, GA, 3Bristol-Myers Squibb, Princeton, NJ

    *Purpose: De novo donor-specific HLA antibodies (dnDSA) that develop after kidney transplantation target more frequently allo-HLA-DQ antigens in comparison to other allo-HLA antigens. Yet, organ…
  • 2018 American Transplant Congress

    MICA/B Polymorphisms and the Relationship of the Matching Degree between MICA/B and HLA of Related Donor-Recipient Pairs in Allo-HSCT

    Y. Sun, Y. Hao, J. Jin, L. Ding, F. Liang, N. Liu, J. Long, X. Zhao, Y. Xi.

    Beijing 307 Hospital, Beijing, China.

    Objective: To explore the distribution characteristics of MICA/B gene polymorphism in the Han Chinese and the relationship of the matching degree between MICA/MICB and HLA…
  • 2018 American Transplant Congress

    Mycophenolate Monotherapy is Safe and Effective in HLA-Matched Kidney Transplant Recipients

    A. Hennes, K. Holdener, W. Burlingham, B. Astor, A. Djamali.

    UW Health, Madison, WI.

    Purpose: The ideal minimizing strategy for maintenance immunosuppression in HLA-matched kidney transplant recipients (KTR) is unknown. We hypothesized that mycophenolate (MPA) monotherapy is a safe…
  • 2018 American Transplant Congress

    HLA Mismatching and cPRA Do Not Affect BK Viremia and Nephropathy Risk in Kidney Transplantation: A Retrospective Analysis

    B. Suleiman, S. Saleh, W. Hassan, K. Wang, A. Maibam, A. Karim, A. Hines, X. Mei, A. El-Husseini, M. Yaseen, V. Cornea, A. Castellanos, R. Gedaly, T. Waid.

    Nephrology, University of Kentucky, Lexington, KY.

    Introduction:Nephropathy from BK virus is a significant complication of kidney transplantation and occurs following a period of viremia. Patients who are HLA mismatched and more…
  • 2018 American Transplant Congress

    Shortened Cold Ischemia Time and Reduced Incidence of Delayed Graft Function for Kidney Transplants through Enhanced Tissue Compatibility Testing

    I. Helanterä,1 T. Saarinen,2 J. Peräsaari,2 M. Lempinen,1 J. Lauronen.2

    1Transplantation and Liver Surgery, Helsinki University Hospital, Helsinki, Finland; 2Histocompatibility Laboratory, Finnish Red Cross Blood Service, Helsinki, Finland.

    A. HLA-typing and prospective leukocyte cross-matching needed for deceased donor kidney transplantation (kTX) may delay the onset of surgery. We compared cold ischemia times (CIT)…
  • 2018 American Transplant Congress

    Epitope/Eplet Mismatch in Pediatric Renal Transplantation and Development of Donor Specific Antibody

    R. George,1 H. Sullivan,2 R. Garro,1 P. Winterberg,1 B. Warshaw,1 H. Gebel,2 R. Bray.2

    1Pediatric Nephrology, Emory University & Children's Healthcare of Atlanta, Atlanta, GA; 2Dept. of Pathology, Emory Transplant Center, Emory University, Atlanta, GA.

    Background: De-novo donor specific antibody (DSA) is one of the strongest independent predictors of graft loss with HLA mismatching being a major risk factor for…
  • 2018 American Transplant Congress

    Feasibility of a National Class II Matching Strategy for Pediatric Kidney Transplant Candidates

    T. Blydt-Hansen,1 W. Klement,2 K. Tinckam,3 J. Gill.1

    1University of British Columbia, Vancouver, Canada; 2Canadian Blood Services, Ottawa, Canada; 3University of Toronto, Toronto, Canada.

    Antibody-mediated rejection (AMR) is a major concern for allograft failure, which could be mitigated by allocation of Class II matched donors. Since children have priority,…
  • 2018 American Transplant Congress

    High Frequency of HLA-DQ De Novo Donor Specific Antibodies is Independent of the Number of Mismatches in Heart Transplant

    X. Zhang,1 E. Kransdorf,2 J. Patel,2 J. Kobashigawa.2

    1HLA and Immunogenetics Laboratory/ Comprehensive Transplant Center, Cedars-Sinai Health Systems, Los Angeles, CA; 2Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA.

    Aim: Development of de novo donor specific antibodies (DSA) after heart transplant is associated with an increased risk of allograft failure. The aim of this…
  • 2018 American Transplant Congress

    Shared HLA Specificities between the Blood and Transplant Donor Increases the Risk of De Novo DSA Development Following Blood Transfusion in Transplant Recipients

    S. Hassan,1 F. Regan,2 C. Brown,3 A. Harmer,2 N. Anderson,2 E. Santos,4 P. Brookes,4 D. Taube,1 M. Willicombe.1

    1Renal and Transplant Centre, Imperial College Healthcare NHS Trust, London, United Kingdom; 2Haematology, Imperial College Healthcare NHS Trust, London, United Kingdom; 3Histocompatibility and Immunogenetics, NHS Blood and Transplant, London, United Kingdom; 4Histocompatibility and Immunogenetics, Imperial College Healthcare NHS Trust, London, United Kingdom.

    Introduction: Blood transfusions post-transplant have been shown to be associated with the development of de novo DSA and inferior allograft outcomes. The mechanisms behind this…
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