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Articles tagged "HLA matching"

  • 2019 American Transplant Congress

    Predictors and Outcomes of Acute Graft-versus-Host Disease after Liver Transplant

    A. Caines1, S. Nagai2, R. Salgia1

    1Gastroenterology and Hepatology, Henry Ford Health System, Detroit, MI, 2Transplant Surgery, Henry Ford Health System, Detroit, MI

    *Purpose: Graft-versus-Host Disease (GVHD) is a rare complication of liver transplant (LT) that has an estimated incidence of 0.1%-2% per year and is associated with…
  • 2019 American Transplant Congress

    Development of a Recurrence Risk Score in IgA Nephropathy after Kidney Transplantation: Role of Recipient Age and HLA-B Mismatch

    L. M. Rodas Marin1, E. Ruiz2, A. García3, M. Blasco1, P. Ventura1, E. de Soussa1, O. Viñas4, F. Diekmann1, L. Quintana1

    1Nephrology and Renal Trasplantation, Hospital Clinic, Barcelona, Spain, 2Immunology, Hospital Clinic, Barcelona, Spain, 3Pathology, Hospital Clinic, Barcelona, Spain, 4Inmunology, Hospital Clinic, Barcelona, Spain

    *Purpose: Recurrence of IgA nephropathy is an important and growing cause of kidney allograft dysfunction. The purpose of this observational retrospective study was to characterize…
  • 2018 American Transplant Congress

    Shared HLA Specificities between the Blood and Transplant Donor Increases the Risk of De Novo DSA Development Following Blood Transfusion in Transplant Recipients

    S. Hassan,1 F. Regan,2 C. Brown,3 A. Harmer,2 N. Anderson,2 E. Santos,4 P. Brookes,4 D. Taube,1 M. Willicombe.1

    1Renal and Transplant Centre, Imperial College Healthcare NHS Trust, London, United Kingdom; 2Haematology, Imperial College Healthcare NHS Trust, London, United Kingdom; 3Histocompatibility and Immunogenetics, NHS Blood and Transplant, London, United Kingdom; 4Histocompatibility and Immunogenetics, Imperial College Healthcare NHS Trust, London, United Kingdom.

    Introduction: Blood transfusions post-transplant have been shown to be associated with the development of de novo DSA and inferior allograft outcomes. The mechanisms behind this…
  • 2018 American Transplant Congress

    HLA Eplet Mismatch and Donor Specific Antibodies in Kidney Transplantation

    S. Wan,1,2 S. Angel de Wilde,2 B. Rosales,2 S. Chadban,1,2 K. Wyburn.1,2

    1Department of Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia; 2Sydney Medical School, University of Sydney, Sydney, Australia.

    BACKGROUND: Although HLA matching improves graft survival in kidney transplant recipients (KTx), eplet mismatches provide higher resolution information, and could better predict the development of…
  • 2018 American Transplant Congress

    The Results of Plasmapheresis and Anti-CD20 Based Desensitization without Intravenous Immunoglobulin in Positive Crossmatch Kidney Transplants

    H. Kwon, Y. KIm, J. Choi, S. Shin, J. Jung, M. Cho, J. Kim, D. Han.

    Asan Medical Center, Seoul, Korea.

    This study examined the mid-term clinical outcomes in positive crossmatch kidney transplants (XMKT) for patients who received desensitization with plasmapheresis (PP) and anti-CD20 based regimens…
  • 2018 American Transplant Congress

    Temporal Changes in Impact of HLA Mismatch among Pediatric Kidney Transplant Recipients

    J. Ruck, A. Massie, N. Desai, D. Segev, J. Garonzik-Wang.

    Johns Hopkins University School of Medicine, Baltimore, MD.

    U.S. pediatric deceased-donor kidney transplantation (pDDKT) allocation now deemphasizes HLA matching to improve equality in access to transplantation, but other national systems still consider HLA…
  • 2018 American Transplant Congress

    ABO Incompatible Deceased Donor Kidney Transplantation – Time to Remove the Barrier

    J. Melancon,1 M. Nayebpour,2 K. Mahendran,1 H. Spivak,1 N. Koizumi.2

    1Transplant Institute and Division of Transplant Surgery, The George Washington University Hospital, Washington, DC; 2George Mason University, Washington, DC.

    Objective: To propose a new allocation system for deceased donor kidney transplants that would decrease cold ischemia time, increase HLA matching, decrease kidney discard rates…
  • 2018 American Transplant Congress

    Induction Type and Outcomes in HLA-DR Mismatch Kidney Transplantation

    K. Sureshkumar, S. Hussain, B. Chopra.

    Nephrology and Hypertension, Allegheny General Hospital, Pittsburgh, PA.

    In kidney transplantation, donor-recipient HLA-DR mismatch is considered high immunologic risk portending inferior outcomes. We sought to explore the impact of induction type used on…
  • 2018 American Transplant Congress

    Correlation of Kidney Transplant Human Leukocyte Antigen Eplet Mismatching to De Novo Donor Specific Antibody Production and Post-Transplant Outcomes

    R. Samudralwar,1 K. Szempruch,1 C. Reuter,3 B. Franz,4 R. Lee,1 E. Weimer,4 R. Detwiler,2 T. Kozlowski,2 J. Schmitz.4

    1Department of Pharmacy, Universitty of North Carolina Medical Center, Chapel Hill, NC; 2Department of Surgery, Universitty of North Carolina Medical Center, Chapel Hill, NC; 3Department of Pharmacy, Ochsner Health System, New Orleans, LA; 4Department of Pathology, University of North Carolina Medical Center, Chapel Hill, NC.

    Human Leukocyte Antigen (HLA) eplet mismatches (EMM) are associated with the development of de novo donor specific antibody (dnDSA) in kidney transplant recipients (KTRs). There…
  • 2018 American Transplant Congress

    HLA Typing, Panel Reactive Antibody and Donor Specific Antigen Tests Are Not Necessary for Successful Parathyroid Allotransplantation

    E. Kanimdan,1 B. Goncu,2 Y. Gelmez,3 O. Idiz,4 C. Toka,5 B. Ozdemir,2 H. Basoglu,6 N. Ozten Kandas,7 E. Yucesan,8 Y. Ersoy,5 R. Kazancioglu,9 E. Aysen.5

    1Bezmialem Vakif University, Faculty of Medicine, Department of Medical Biology, Istanbul, Turkey; 2Bezmialem Vakif University, Experimental Research Center, Istanbul, Turkey; 3Istanbul University, Aziz Sancar Institute of Experimental Medicine, Department of Immunology, Istanbul, Turkey; 4Istanbul Training and Research Hospital, Department of General Surgery, Istanbul, Turkey; 5Bezmialem Vakif University, Faculty of Medicine, Department of General Surgery, Istanbul, Turkey; 6Bezmialem Vakif University, Faculty of Medicine, Department of Biophysics, Istanbul, Turkey; 7Bezmialem Vakif University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Istanbul, Turkey; 8Bezmialem Vakif University, Institute of Life Sciences and Biotechnology, Istanbul, Turkey; 9Bezmialem Vakif University, Faculty of Medicine, Department of Internal Medicine, Istanbul, Turkey.

    Permanent hypoparathyroidism(PH) is incurable condition and requires life long drug therapy.Unique therapeutic option is parathyroid allotransplantation(PA).Some studies use routinely but emprically HLA typing,PRA(panel reactive antibody)…
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