ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "HLA matching"

  • 2019 American Transplant Congress

    Human Leukocyte Antigen Class I (HLA-I) Antibodies in Patients Undergoing Liver Transplantation: Implications for Platelet Transfusion Support

    M. Wong1, R. Narra2, M. Selim1, M. A. Zimmerman1, A. Padmanabhan3, J. C. Hong1

    1Div. of Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI, 2Div. of Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI, 3Medical College of Wisconsin and BloodCenter of Wisconsin, Milwaukee, WI

    *Purpose: Liver transplantation is a high platelet transfusion (PLT) setting due to the elevated incidence of thrombocytopenia and bleeding. HLA-I antibodies are thought to have…
  • 2019 American Transplant Congress

    The Impact of Eplet Mismatches on Kidney Transplant Outcome: A Single-Center Cohort Study

    A. Senev1, M. Coemans1, V. Van Sandt2, B. Sprangers3, D. Kuypers3, M. Emonds2, M. Naesens3

    1Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium, 2Histocompatibility and Immunogenetics Laboratory, Belgian Red Cross-Flanders, Mechelen, Belgium, 3University Hospitals Leuven, Leuven, Belgium

    *Purpose: It has been shown that HLA-matching at classic antigen-level for HLA-A, -B and -DRB1 loci, provides benefits in matching and outcome after solid organ…
  • 2018 American Transplant Congress

    ABO Incompatible Deceased Donor Kidney Transplantation – Time to Remove the Barrier

    J. Melancon,1 M. Nayebpour,2 K. Mahendran,1 H. Spivak,1 N. Koizumi.2

    1Transplant Institute and Division of Transplant Surgery, The George Washington University Hospital, Washington, DC; 2George Mason University, Washington, DC.

    Objective: To propose a new allocation system for deceased donor kidney transplants that would decrease cold ischemia time, increase HLA matching, decrease kidney discard rates…
  • 2018 American Transplant Congress

    Induction Type and Outcomes in HLA-DR Mismatch Kidney Transplantation

    K. Sureshkumar, S. Hussain, B. Chopra.

    Nephrology and Hypertension, Allegheny General Hospital, Pittsburgh, PA.

    In kidney transplantation, donor-recipient HLA-DR mismatch is considered high immunologic risk portending inferior outcomes. We sought to explore the impact of induction type used on…
  • 2018 American Transplant Congress

    Correlation of Kidney Transplant Human Leukocyte Antigen Eplet Mismatching to De Novo Donor Specific Antibody Production and Post-Transplant Outcomes

    R. Samudralwar,1 K. Szempruch,1 C. Reuter,3 B. Franz,4 R. Lee,1 E. Weimer,4 R. Detwiler,2 T. Kozlowski,2 J. Schmitz.4

    1Department of Pharmacy, Universitty of North Carolina Medical Center, Chapel Hill, NC; 2Department of Surgery, Universitty of North Carolina Medical Center, Chapel Hill, NC; 3Department of Pharmacy, Ochsner Health System, New Orleans, LA; 4Department of Pathology, University of North Carolina Medical Center, Chapel Hill, NC.

    Human Leukocyte Antigen (HLA) eplet mismatches (EMM) are associated with the development of de novo donor specific antibody (dnDSA) in kidney transplant recipients (KTRs). There…
  • 2018 American Transplant Congress

    HLA Typing, Panel Reactive Antibody and Donor Specific Antigen Tests Are Not Necessary for Successful Parathyroid Allotransplantation

    E. Kanimdan,1 B. Goncu,2 Y. Gelmez,3 O. Idiz,4 C. Toka,5 B. Ozdemir,2 H. Basoglu,6 N. Ozten Kandas,7 E. Yucesan,8 Y. Ersoy,5 R. Kazancioglu,9 E. Aysen.5

    1Bezmialem Vakif University, Faculty of Medicine, Department of Medical Biology, Istanbul, Turkey; 2Bezmialem Vakif University, Experimental Research Center, Istanbul, Turkey; 3Istanbul University, Aziz Sancar Institute of Experimental Medicine, Department of Immunology, Istanbul, Turkey; 4Istanbul Training and Research Hospital, Department of General Surgery, Istanbul, Turkey; 5Bezmialem Vakif University, Faculty of Medicine, Department of General Surgery, Istanbul, Turkey; 6Bezmialem Vakif University, Faculty of Medicine, Department of Biophysics, Istanbul, Turkey; 7Bezmialem Vakif University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Istanbul, Turkey; 8Bezmialem Vakif University, Institute of Life Sciences and Biotechnology, Istanbul, Turkey; 9Bezmialem Vakif University, Faculty of Medicine, Department of Internal Medicine, Istanbul, Turkey.

    Permanent hypoparathyroidism(PH) is incurable condition and requires life long drug therapy.Unique therapeutic option is parathyroid allotransplantation(PA).Some studies use routinely but emprically HLA typing,PRA(panel reactive antibody)…
  • 2018 American Transplant Congress

    MICA/B Polymorphisms and the Relationship of the Matching Degree between MICA/B and HLA of Related Donor-Recipient Pairs in Allo-HSCT

    Y. Sun, Y. Hao, J. Jin, L. Ding, F. Liang, N. Liu, J. Long, X. Zhao, Y. Xi.

    Beijing 307 Hospital, Beijing, China.

    Objective: To explore the distribution characteristics of MICA/B gene polymorphism in the Han Chinese and the relationship of the matching degree between MICA/MICB and HLA…
  • 2018 American Transplant Congress

    Mycophenolate Monotherapy is Safe and Effective in HLA-Matched Kidney Transplant Recipients

    A. Hennes, K. Holdener, W. Burlingham, B. Astor, A. Djamali.

    UW Health, Madison, WI.

    Purpose: The ideal minimizing strategy for maintenance immunosuppression in HLA-matched kidney transplant recipients (KTR) is unknown. We hypothesized that mycophenolate (MPA) monotherapy is a safe…
  • 2018 American Transplant Congress

    HLA Mismatching and cPRA Do Not Affect BK Viremia and Nephropathy Risk in Kidney Transplantation: A Retrospective Analysis

    B. Suleiman, S. Saleh, W. Hassan, K. Wang, A. Maibam, A. Karim, A. Hines, X. Mei, A. El-Husseini, M. Yaseen, V. Cornea, A. Castellanos, R. Gedaly, T. Waid.

    Nephrology, University of Kentucky, Lexington, KY.

    Introduction:Nephropathy from BK virus is a significant complication of kidney transplantation and occurs following a period of viremia. Patients who are HLA mismatched and more…
  • 2018 American Transplant Congress

    Shortened Cold Ischemia Time and Reduced Incidence of Delayed Graft Function for Kidney Transplants through Enhanced Tissue Compatibility Testing

    I. Helanterä,1 T. Saarinen,2 J. Peräsaari,2 M. Lempinen,1 J. Lauronen.2

    1Transplantation and Liver Surgery, Helsinki University Hospital, Helsinki, Finland; 2Histocompatibility Laboratory, Finnish Red Cross Blood Service, Helsinki, Finland.

    A. HLA-typing and prospective leukocyte cross-matching needed for deceased donor kidney transplantation (kTX) may delay the onset of surgery. We compared cold ischemia times (CIT)…
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