Articles tagged "HLA-DR allopeptides"

2022 American Transplant Congress
Bystander Suppression: Enhancing the Power of Ex Vivo Expanded Antigen Specific Regulatory Cell Lines
S. Tripathi¹, P. L. Martin-Moreno², G. J. Kavalam³, B. Schreiber³, A. Wagaa-Gasser¹, A. Chandraker⁴
¹Renal, Brigham and Women's Hospital, Boston, MA, ²Nephrology, Clinica Universidad de Navarra, Ripagaina, Spain, ³Brigham and Women's Hospital, Boston, MA, ⁴Medicine, Brigham and Women's Hospital, Boston, MA
*Purpose: The potential of T regulatory cell (Treg) based therapies in transplantation has been demonstrated in various preclinical models. Multiple clinical trials are currently undergoing…
2022 American Transplant Congress
Production of Exosomal IL35 from Alloreactive Treg Cells: A Basis for Potent Immunotherapy and Tolerance in Human Kidney Transplantation
W. J. Burlingham¹, E. Jankowska-Gan², J. Fechner¹, C. Little¹, S. Tripathi³, B. Schreiber³, A. Chandraker³, D. Foley⁴
¹Surgery-Transplant Division, University of Wisconsin, Madison, WI, ²Surgery-Transplant Division, University of Wisconsin-Madison, Madison, WI, ³Surgery-Transplant Division, Brigham & Women's Hospital, Boston, MA, ⁴University of Wisconsin, Madison, WI
*Purpose: Treg cells make a variety of immunosuppressive products—cytokines such as IL10, TGFβ, and IL35, and enzymes such as the CD39/CD73 pair that convert extracellular…
2018 American Transplant Congress
The Overriding Importance of HLA-DR Donor-Specific Antibody That is Correlated to CAV after Heart Transplant
E. Kransdorf, J. Patel, M. Kittleson, S. Dimbil, R. Levine, D. Geft, D. Chang, L. Czer, J. Kobashigawa.
Cedars Sinai Medical Center, Los Angeles.
Purpose: Class II donor specific anti-HLA antibodies (DSA) have been correlated to subsequent CAV development. More specifically, HLA-DQ has been most reported for CAV development.…