ATC Abstracts

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Articles tagged "HLA antigens"

  • 2016 American Transplant Congress

    HLA Class II and BK Virus Reactivation in Renal Transplant Recipients.

    P. Shah,1 K. Anderson,2 M. Aubrey,2 C. Roark,2 B. Freed,2 A. Wiseman.1

    1Division of Renal Diseases and Hypertension, University of Colorado School of Medicine, Aurora, CO; 2Division of Immunology, University of Colorado School of Medicine, Aurora, CO.

    BK Viremia (BKV) and subsequent BK nephropathy are associated with renal graft loss. The Human Leukocyte Antigen (HLA) region has been implicated in susceptibility to…
  • 2016 American Transplant Congress

    Blocking MHC Class II on Human Endothelium Mitigates Acute Rejection of Vessel Allografts by Effector Memory T Cells.

    P. Abrahimi,1 L. Qin,2 W. Chang,1 A. Bothwell,1 G. Tellides,2 W. Saltzman,3 J. Pober.1

    1Immunobiology, Yale School of Medicine, New Haven, CT; 2Surgery, Yale School of Medicine, New Haven, CT; 3Biomedical Engineering, Yale University, New Haven, CT.

    Acute allograft rejection is mediated by alloreactive CD8+ T cells that differentiate into cytotoxic lymphocytes (CTL). In most rodent models, CTL differentiate from naïve CD8+…
  • 2016 American Transplant Congress

    Blindspots in HLA Antibody Testing: Recognition Is First Step to Nirvana.

    A. Kher, P. Dorwal, V. Kher.

    Medanta-The Medicity, Gurgaon, Haryana, India.

    This study was conducted to assess population frequency of alleles missing from single antigen bead (SAB) panels & frequency of allelic antibodies (Abs).Methods: All positive…
  • 2016 American Transplant Congress

    Epitope Load Is Predictive of De Novo Donor Specific Antibodies Occurrence in Renal Transplant Recipients After Conversion from Cyclosporine to Everolimus.

    R. Snanoudj,1 C. Suberbielle,2 N. Kamar,3 E. Cassuto,4 S. Caillard,5 J.-L. Taupin,2 D. Anglicheau,1 C. Legendre,1 A. Hertig,6 E. Rondeau.6

    1Necker Hospital, Paris, France; 2Saint-Louis Hospital, Paris, France; 3Rangueil Hospital, Toulouse, France; 4Pasteur Hospital, Nice, France; 5CHRU, Strasbourg, France; 6Tenon Hospital, Paris, France.

    IntroductionThe degree of HLA compatibility between donor and recipient is an important risk factor of developing de novo DSA, but misjudged by the number of…
  • 2016 American Transplant Congress

    Complex Constellation of HLA Antibodies Contributes to Decreasing Trend of Transplant Rate in Candidates with 100% CPRA.

    R. Rajalingam, D. Hyon Gae, D. Kopchaliiska, O. Buenaventura, K. Cunniffe, G. Da Gente, J. Roberts.

    Immunogenetics and Transplantation Laboratory; Department of Surgery, University of California-San Francisco, San Francisco, CA.

    The key component of new KAS is offering an increased priority for sensitized candidates. While transplants (tx) have increased six-fold for recipients with a CPRA…
  • 2016 American Transplant Congress

    Role of Natural Killer Cells in Kidney Transplant Outcome.

    E. Carta,1 R. Littera,2 M. Murgia,1 M. Michittu,1 B. Onano,1 G. Piredda,1 D. Argiolas.1

    1Renal Transplant Unit, Azienda Brotzu, Cagliari, Italy; 2Regional Transplant Coordination, ASL 8, Cagliari, Italy.

    Aim of the study was to evaluate the relationship between killer cell immunoglobulin-like receptor (KIR) phenotype and kidney transplant rejection. NK-target cell interaction depends on…
  • 2015 American Transplant Congress

    Should Current IVIg Preparations Containing High Titers of Anti-HLA-I/-II IgG be Used for Lowering the Anti-HLA IgG in Sensitized Pre-Transplant Patients and Allograft Recipients?

    M. Ravindranath, P. Terasaki, C. Maehara, V. Jucaud.

    HLA antibodies, Terasaki Foundation Laboratory, Los Angeles, CA.

    Sera of non-alloimmunized individuals contain anti-HLA-I & -II IgG. Therefore it is reasonable expect HLA-I/-II reactivity of Intravenous Immunoglobulin (IVIg). However, the titers at which…
  • 2015 American Transplant Congress

    Antibodies Directed Against HLA-DQ Are Significantly Associated to Complement Activation In Vitro

    J. Arreola-Guerra, A. de Santiago, A. Arvizu, N. Gonzalez-Tableros, M. Lopez, M. Vilatoba, L. Morales-Buenrostro, J. Alberu, N. Castelan.

    1Transplantation, 1aNephrology-Mineral Metabolism, Inst Nal de Ciencias Medicas y Nutricion SZ, Mexico City, Distrito Federal, Mexico.

    Background: C1q-binding HLA antibodies (HLAabs) have been related to acute rejection and long-term graft loss. The characteristics of these antibodies and factors associated to complement…
  • 2015 American Transplant Congress

    Phenotype Characterization, Migratory Pathways, Engraftment and Safety Evaluation of Human Cord Blood Derived Ex-Vivo Created Di- Chimeric Cells in NOD SCID Mouse Model: A Preliminary Study

    J. Cwykiel,1 A. Sklodowska,1 W. Malewski,1 M. Cyran,1 H. Karagoz,1 E. Bryndza Tfaily,1 M. Askar,2 M. Siemionow.1

    1Department of Orthopaedics, University of Illinois at Chicago, Chicago, IL; 2Transplant Center, Cleveland Clinic, Cleveland, OH.

    PURPOSE: The aim of this study was to evaluate safety, survival, migration and engraftment of ex-vivo fused human cord blood derived di-chimeric cells (DCC) in…
  • 2015 American Transplant Congress

    Highly Accurate High-Resolution HLA Imputation Using Dense Genotyping Data

    B. Keating,1 Y. Li,1 T. Guettouche,2 K. Olthoff,1 A. Shaked.1

    1Surgery (Division of Transplantation), University of Pennsylvania, Philadelphia, PA; 2Genetics, Children's Hospital of Philadelphia, Philadelphia, PA.

    HLA similarity between donors (D) and recipients (R) of solid organ transplantation (SOT) plays a central role in determining the risk of rejection or graft-versus-host…
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