ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Highly-sensitized"

  • 2018 American Transplant Congress

    Impact of the New KAS on Transplant Rates in Highly-HLA Sensitized (HS) Patients after Desenstization (DES): 3yrs Post Implementation

    A. Vo, E. Huang, N. Ammerman, S. Williamson, C. Myers, A. Peng, R. Najjar, S. Sethi, K. Lim, S. Jordan.

    Kidney Transplant, Cedars-Sinai Medical Center, LA, CA.

    Introduction: The KAS aims to increase equity in organ allocation for broadly sensitized (HS) patients, especially (CPRA 99-100%). Coupling desensitization (DES) + KAS likely will…
  • 2018 American Transplant Congress

    Follow Up of Patients Treated with the IgG Endopeptidase (IdeS) for Desensitization and HLA Incompatible (HLAi) Kidney Transplantation

    S. Jordan,1 J. Choi,1 E. Huang,1 R. Najjar,1 A. Peng,1 X. Zhang,1 S. Louie,1 M. Haas,2 S. Sethi,1 I. Kim,1 A. Vo.1

    1Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; 2Pathology & Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.

    Introduction:Donor-specific antibodies (DSAs) create an immunologic barrier to transplantation. This prevents transplantation for a significant percentage of highly-HLA sensitized patients (HS). Current desensitization therapies are…
  • 2018 American Transplant Congress

    Molecular Monitoring for Kidney Allograft Injury Following HLA Incompatible Transplantation

    A. Jackson,1 B. Iglehart,1 S. Bagnasco,3 N. Desai.2

    1Medicine, Johns Hopkins University, Baltimore, MD; 2Surgery, Johns Hopkins University, Baltimore, MD; 3Pathology, Johns Hopkins University, Baltimore, MD.

    Elevated donor derived cell free DNA (ddcfDNA) has been shown to correlate with allograft rejection following heart, lung, and kidney transplantation. We investigated whether sequential…
  • 2018 American Transplant Congress

    Impact of De Novo DSA (DnDSA) on Outcomes in HLA-Sensitized (HS) Patients Transplanted after IVIG + Rituximab Desensitization (DES)

    A. Vo,1 O. Aubert,2 H. Edmund,1 A. Peng,1 R. Najjar,1 S. Supreet,1 J. Choi,1 K. Lim,1 S. Jordan.1

    1Kidney Transplant, Cedars-Sinai Medical Center, LA, CA; 2Paris Translational Research Center for Organ Transplantation, Necker Hospital, Paris, France.

    Introduction: Highly-HLA sensitized patients (HS) with donor specific antibodies (DSA) at transplant are at risk for Type 1 ABMR. However, the incidence of Type 2…
  • 2018 American Transplant Congress

    The Clinical Significance of Pretransplant C1q Assay Status in Positive Crossmatch Kidney Transplantation

    J. Lee,1 D. Kim,1 B. Park,2 S. Song,3 J. Lee,4 Y. Jung,1 J. Lee,1 J. Lee,1 B. Kim,5 M. Kim,1 S. Kim,1 Y. Kim,1 K. Huh.1

    1Surgery, Yonsei University College of Medicine, Seoul, Korea; 2Laboratory Medicine, Asan MEdical Center, Seoul, Korea; 3Surgery, Ewha Womans University, School of Medicine, Seoul, Korea; 4Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea; 5Internal Medicine (Nephrology), Yonsei University College of Medicine, Seoul, Korea.

    Background: Patients with a pretransplant donor-specific antibodies (DSA) are at higher risk for antibody-mediated rejection (AMR). However, not all DSA have the same pathogenetic potential.…
  • 2018 American Transplant Congress

    Non Active Desensitization Protocol: Improving Access to Kidney Transplant for Hyperimmunized Patients

    S. Le Bot,1 F. Delbos,2 C. Garandeau,1 S. Malard Castagnet,2 A. Cesbron,2 M. Hourmant.1

    1Nephrology and Transplantation, CHU Hôtel Dieu, Nantes, France; 2Laboratoire HLA, Etablissement Français du Sang, Nantes, France.

    Hyperimmunized patients have a bad access to renal transplantation, despite national priority programs and active desensitization protocols. After having noticed that some HLA antibodies decreased…
  • 2018 American Transplant Congress

    Immuoadsorption-Based Desensitization in Highly Sensitized Patients Awaiting Deceased Donor Kidney Transplantation.

    C. Bureau, P. Galichon, Y. Luque, N. Ouali, E. Rondeau, C. Rafat.

    Urgences Néphrologiques et Transplantation Rénale, Tenon Hospital, APHP, Paris, France.

    An estimated 30% of patients on the waiting list are deemed highly sensitized due to preexisting anti-HLA antibodies often irrevocably precluding kidney transplantation (KT). Immunoadsorption…
  • 2018 American Transplant Congress

    Sharing Works; Avoiding Kidney Transplantation to an Unintended Recipient by Precision Virtual Cross Match with Excellent Outcomes

    G. Roll,1 A. Webber,1 M. Travakol,1 D. Gae,1 L. Mayen,2 V. Corpuz,1 J. Roberts,1 N. Ascher,1 P. Stock,1 R. Rajalingam.1

    1UCSF, San Francisco; 2Donor Network West, San Ramon.

    Aim: It was recently estimated that 19.2% of imported kidneys go into an unintended recipient(UR), most commonly due to a positive crossmatch(AJT 2017, 17:2139) so…
  • 2018 American Transplant Congress

    Kidney Transplant Outcomes in Patients with CPRA Values > 98% after Implementation of the New OPTN/UNOS Kidney Allocation System (KAS): A Single Center Study Update

    N. Kaur,1 M. Kamoun,2 J. Kearns,2 J. Trofe-Clark,1 P. Abt,3 M. Levine,3 S. Goral.1

    1Department of Medicine, Renal-Electrolyte and Hypertension Division, Hospital of the University of Pennsylvania, Philadelphia; 2Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia; 3Surgery, Hospital of the University of Pennsylvania, Philadelphia.

    Background: Sensitized patients in the past have had prolonged waiting times and greater incidence of death while on the waiting list. On December 4, 2014,…
  • 2018 American Transplant Congress

    Complement Activating HLA Class 2 Antibodies Are Associated with Poor Renal Allograft Survival; Multicentre Study

    A. Babu,1,2 O. Shaw,5 N. Khovanova,2 S. Griffin,4 D. Briggs,6 N. Krishnan,1 S. Fletcher,1 C. Imray,1 A. Seitz,3 R. Baker,3 M. Wellberry-Smith,3 B. Clarke,3 K. Cullen,3 F. Edwards,4 T. Rees,4 E. Burrows,4 L. Howe,5 R. Vaughan,5 N. Kessaris,7 N. Mamode,7 A. Dorling,7 D. Zehnder,1 R. Higgins,1,2 D. Mitchell,2 S. Daga.2,3

    1Renal Transplantation, University Hospitals Coventry, Coventry, United Kingdom; 2University of Warwick, Coventry, United Kingdom; 3Renal Transplantation, St James University Hospital, Leeds, United Kingdom; 4Renal Transplantation, University Hospital of Wales, Cardiff, United Kingdom; 5H&I, Viapath,, London, United Kingdom; 6H&I, NHSBT, Birmingham, United Kingdom; 7Renal Transplantation, Guys and St Thomas Hospital, London, United Kingdom.

    IntroductionRole of Class I and II pre-formed complement activating antibodies on renal outcomes is not well defined. In this multicentre study, we looked at the…
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