Articles tagged "Highly-sensitized"

2019 American Transplant Congress
Differences in Wait Time, Graft Quality and Outcome for Pediatric Kidney Recipients in the Post-Kidney Allocation System Era
P. Singer, K. Eng, L. Castellanos Reyes, C. Sethna, L. Teperman, E. Grodstein
Northwell Health, Manhasset, NY
*Purpose: Though a purpose of the kidney allocation system (KAS) enacted in 2014 was to prioritize the transplantation of highly sensitized recipients, we explored the…
2019 American Transplant Congress
BK Virus Infection among Kidney Transplant Recipients with High Immunological Risk and Strong Immunosupression
G. Ledesma, M. O. Lopez, G. Carreño, M. J. Santana, M. A. Vaca, E. Gonzalez, C. Jimenez
Nephrology, Hospital Universitario La Paz, Madrid, Spain
*Purpose: BK virus infection represents one of the main viral infections within the first year after kidney transplantation, closely linked to the degree of immunosupresion.…
2019 American Transplant Congress
Autoantibody Production Significantly Decreased with APRIL/BLyS Blockade in Murine Chronic Rejection Kidney Transplant Model
N. Bath, X. Ding, B. Verhoven, S. Reese, N. Wilson, A. Sukhwal, R. Redfield III
University of Wisconsin, Madison, WI
*Purpose: Chronic antibody mediated rejection (cAMR) remains a significant barrier to achieving long-term graft survival in kidney transplantation. Alloantibody production from B lymphocytes and plasma…
2019 American Transplant Congress
Kidney & Pancreas Transplant Waitlist Management – A Tiered System Approach
H. L. Busch
Transplant, UCI Health, Orange, CA
*Purpose: Developed and implemented an innovative kidney & pancreas transplant waitlist management system in order to more effectively and efficiently re-evaluate patients on a transplant…
2019 American Transplant Congress
Long Term Outcomes Using Tocilizumab For The Treatment Of Chronic Antibody Mediated Rejection
J. Choi¹, E. Huang¹, O. Aubert², A. Vo¹, A. Peng¹, R. Najjar¹, S. Sethi¹, N. Ammerman¹, K. Lim¹, D. Puliyanda¹, A. Loupy², S. Jordan¹
¹Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA, ²Paris Translational Center for Organ Transplantation, Paris, France
*Purpose: Limited options exist for the treatment of kidney allograft rejection and preservation of allograft function. We reported our experience with anti-IL-6R (tocilizumab, TCZ) as…
2019 American Transplant Congress
Compatible Pairs in Paired Kidney Exchange – Are There Winners and Loosers?
V. Chipman¹, B. Lee¹, M. Cooper², M. C. Cuffy³, M. Ronin⁴, G. Hil⁴, S. Flechner⁵, A. Thomas⁶, D. A. Mandelbrot⁷, A. D. Waterman⁸, C. E. Freise¹, G. R. Roll¹
¹UCSF, San Francisco, CA, ²Georgetown Univ, Washington, DC, ³UC Hospital, Cincinnati, OH, ⁴NKR, Babylon, NY, ⁵Cleavland Clinic, Cleavland, OH, ⁶Johns Hopkins, Baltimore, MD, ⁷Univ of Wisconsin, Madison, WI, ⁸UCLA and Terasaki Research Institute, Los Angeles, CA
*Purpose: To understand patterns of participation for compatible pairs and their impact in increasing paired donation in a national registry.*Methods: Favorable pairs (FP) are defined…
2019 American Transplant Congress
Three-Year Outcomes of Highly-Sensitized Kidney Transplant Recipients Desensitized with Imlifidase (IdeS)
E. Huang¹, J. Choi¹, A. Vo¹, A. Peng¹, R. Najjar¹, S. Sethi¹, C. Kjellman², L. Winstedt², N. Ammerman¹, S. C. Jordan¹
¹Cedars Sinai Medical Center, Los Angeles, CA, ²Hansa Medical, Lund, Sweden
*Purpose: The HLA-incompatible (HLAi) barrier has been traversed using desensitization therapies with IVIg, rituximab and/or plasmapheresis, although antibody-mediated rejection (ABMR) continues to be observed in…
2019 American Transplant Congress
B Cell Derived Exosomes Are Associated with Antibody Mediated Rejection in Kidney Transplant Recipients Desensitized for a Positive Cross-Match
D. Cucchiari¹, V. Tubita², M. J. Ramirez-Bajo², J. Rovira², F. E. Borràs³, L. Carreras-Planella³, A. Hertig⁴, F. Oppenheimer¹, F. Diekmann¹, I. Revuelta¹
¹Renal Transplant Unit, Hospital Clínic, Barcelona, Spain, ²Laboratori Experimental de Nefrologia i Trasplantament, IDIBAPS, Barcelona, Spain, ³REMAR-IVECAT group, IGTP, Badalona, Spain, ⁴Department of Nephrology and Kidney Transplantation, Hôpital Tenon, Paris, France
*Purpose: Kidney transplant recipients undergoing desensitization for a positive cross-match are at very high risk of developing Antibody-Mediated Rejection (AMR). Because of desensitization, peripheral circulating…
2019 American Transplant Congress
Characterization of HLA Antibodies by C3d Assay and IgG Subclasses in Sensitized Kidney Transplant Patients
A. Casillas-Abundis, J. M. Arreola-Guerra, J. Alberu, M. I. Solis-G, L. Llorente, J. Granados, M. Vilatoba, R. Cruz-Martinez, L. Morales-Buenrostro, A. G. Contreras
Instituto Nacional de Ciencias Medicas y Nutricion SZ, Mexico City, Mexico
*Purpose: To determine the detection rate of IgG subclasses (IgGsc) and C3d-binding HLA-antibodies (abs) in a cohort of highly sensitized kidney transplant patients.*Methods: We evaluated,…
2018 American Transplant Congress
Sharing Works; Avoiding Kidney Transplantation to an Unintended Recipient by Precision Virtual Cross Match with Excellent Outcomes
G. Roll,¹ A. Webber,¹ M. Travakol,¹ D. Gae,¹ L. Mayen,² V. Corpuz,¹ J. Roberts,¹ N. Ascher,¹ P. Stock,¹ R. Rajalingam.¹
¹UCSF, San Francisco; ²Donor Network West, San Ramon.
Aim: It was recently estimated that 19.2% of imported kidneys go into an unintended recipient(UR), most commonly due to a positive crossmatch(AJT 2017, 17:2139) so…

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