2019 American Transplant Congress
Autoantibody Production Significantly Decreased with APRIL/BLyS Blockade in Murine Chronic Rejection Kidney Transplant Model
University of Wisconsin, Madison, WI
*Purpose: Chronic antibody mediated rejection (cAMR) remains a significant barrier to achieving long-term graft survival in kidney transplantation. Alloantibody production from B lymphocytes and plasma…2019 American Transplant Congress
Kidney & Pancreas Transplant Waitlist Management – A Tiered System Approach
Transplant, UCI Health, Orange, CA
*Purpose: Developed and implemented an innovative kidney & pancreas transplant waitlist management system in order to more effectively and efficiently re-evaluate patients on a transplant…2019 American Transplant Congress
Long Term Outcomes Using Tocilizumab For The Treatment Of Chronic Antibody Mediated Rejection
*Purpose: Limited options exist for the treatment of kidney allograft rejection and preservation of allograft function. We reported our experience with anti-IL-6R (tocilizumab, TCZ) as…2019 American Transplant Congress
Compatible Pairs in Paired Kidney Exchange – Are There Winners and Loosers?
*Purpose: To understand patterns of participation for compatible pairs and their impact in increasing paired donation in a national registry.*Methods: Favorable pairs (FP) are defined…2019 American Transplant Congress
Three-Year Outcomes of Highly-Sensitized Kidney Transplant Recipients Desensitized with Imlifidase (IdeS)
1Cedars Sinai Medical Center, Los Angeles, CA, 2Hansa Medical, Lund, Sweden
*Purpose: The HLA-incompatible (HLAi) barrier has been traversed using desensitization therapies with IVIg, rituximab and/or plasmapheresis, although antibody-mediated rejection (ABMR) continues to be observed in…2019 American Transplant Congress
B Cell Derived Exosomes Are Associated with Antibody Mediated Rejection in Kidney Transplant Recipients Desensitized for a Positive Cross-Match
*Purpose: Kidney transplant recipients undergoing desensitization for a positive cross-match are at very high risk of developing Antibody-Mediated Rejection (AMR). Because of desensitization, peripheral circulating…2019 American Transplant Congress
Characterization of HLA Antibodies by C3d Assay and IgG Subclasses in Sensitized Kidney Transplant Patients
Instituto Nacional de Ciencias Medicas y Nutricion SZ, Mexico City, Mexico
*Purpose: To determine the detection rate of IgG subclasses (IgGsc) and C3d-binding HLA-antibodies (abs) in a cohort of highly sensitized kidney transplant patients.*Methods: We evaluated,…2019 American Transplant Congress
Validation of Gene Expression Signatures Associated with Antibody-Mediated Rejection (ABMR) in Renal Allograft Biopsies (Bx) of HLA-Sensitized Patients
*Purpose: "Thoroughly validated gene transcripts” in renal Bx was adopted as one of the criteria for ABMR diagnosis in the latest Banff classification. Previously, we…2019 American Transplant Congress
Vaccination And Allosensitization In Solid Organ Transplant Candidates
*Purpose: Clinical practice guidelines recommend vaccinating patients awaiting solid organ transplantation (SOT) against vaccine-preventable infections, but there is little evidence to suggest that vaccination reduces…2019 American Transplant Congress
Rejection, Infectious, and Renal Outcomes with Perioperative Desensitization in Orthotopic Heart Transplant Recipients
University of Maryland Medical Center, Baltimore, MD
*Purpose: Pre-transplant allosensitization remains a significant barrier to organ allocation and a paucity of evidence exists to demonstrate the efficacy and safety of perioperative desensitization…
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