ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Highly-sensitized"

  • 2019 American Transplant Congress

    Autoantibody Production Significantly Decreased with APRIL/BLyS Blockade in Murine Chronic Rejection Kidney Transplant Model

    N. Bath, X. Ding, B. Verhoven, S. Reese, N. Wilson, A. Sukhwal, R. Redfield III

    University of Wisconsin, Madison, WI

    *Purpose: Chronic antibody mediated rejection (cAMR) remains a significant barrier to achieving long-term graft survival in kidney transplantation. Alloantibody production from B lymphocytes and plasma…
  • 2019 American Transplant Congress

    Kidney & Pancreas Transplant Waitlist Management – A Tiered System Approach

    H. L. Busch

    Transplant, UCI Health, Orange, CA

    *Purpose: Developed and implemented an innovative kidney & pancreas transplant waitlist management system in order to more effectively and efficiently re-evaluate patients on a transplant…
  • 2019 American Transplant Congress

    Long Term Outcomes Using Tocilizumab For The Treatment Of Chronic Antibody Mediated Rejection

    J. Choi1, E. Huang1, O. Aubert2, A. Vo1, A. Peng1, R. Najjar1, S. Sethi1, N. Ammerman1, K. Lim1, D. Puliyanda1, A. Loupy2, S. Jordan1

    1Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA, 2Paris Translational Center for Organ Transplantation, Paris, France

    *Purpose: Limited options exist for the treatment of kidney allograft rejection and preservation of allograft function. We reported our experience with anti-IL-6R (tocilizumab, TCZ) as…
  • 2019 American Transplant Congress

    Compatible Pairs in Paired Kidney Exchange – Are There Winners and Loosers?

    V. Chipman1, B. Lee1, M. Cooper2, M. C. Cuffy3, M. Ronin4, G. Hil4, S. Flechner5, A. Thomas6, D. A. Mandelbrot7, A. D. Waterman8, C. E. Freise1, G. R. Roll1

    1UCSF, San Francisco, CA, 2Georgetown Univ, Washington, DC, 3UC Hospital, Cincinnati, OH, 4NKR, Babylon, NY, 5Cleavland Clinic, Cleavland, OH, 6Johns Hopkins, Baltimore, MD, 7Univ of Wisconsin, Madison, WI, 8UCLA and Terasaki Research Institute, Los Angeles, CA

    *Purpose: To understand patterns of participation for compatible pairs and their impact in increasing paired donation in a national registry.*Methods: Favorable pairs (FP) are defined…
  • 2019 American Transplant Congress

    Three-Year Outcomes of Highly-Sensitized Kidney Transplant Recipients Desensitized with Imlifidase (IdeS)

    E. Huang1, J. Choi1, A. Vo1, A. Peng1, R. Najjar1, S. Sethi1, C. Kjellman2, L. Winstedt2, N. Ammerman1, S. C. Jordan1

    1Cedars Sinai Medical Center, Los Angeles, CA, 2Hansa Medical, Lund, Sweden

    *Purpose: The HLA-incompatible (HLAi) barrier has been traversed using desensitization therapies with IVIg, rituximab and/or plasmapheresis, although antibody-mediated rejection (ABMR) continues to be observed in…
  • 2019 American Transplant Congress

    B Cell Derived Exosomes Are Associated with Antibody Mediated Rejection in Kidney Transplant Recipients Desensitized for a Positive Cross-Match

    D. Cucchiari1, V. Tubita2, M. J. Ramirez-Bajo2, J. Rovira2, F. E. Borràs3, L. Carreras-Planella3, A. Hertig4, F. Oppenheimer1, F. Diekmann1, I. Revuelta1

    1Renal Transplant Unit, Hospital Clínic, Barcelona, Spain, 2Laboratori Experimental de Nefrologia i Trasplantament, IDIBAPS, Barcelona, Spain, 3REMAR-IVECAT group, IGTP, Badalona, Spain, 4Department of Nephrology and Kidney Transplantation, Hôpital Tenon, Paris, France

    *Purpose: Kidney transplant recipients undergoing desensitization for a positive cross-match are at very high risk of developing Antibody-Mediated Rejection (AMR). Because of desensitization, peripheral circulating…
  • 2019 American Transplant Congress

    Characterization of HLA Antibodies by C3d Assay and IgG Subclasses in Sensitized Kidney Transplant Patients

    A. Casillas-Abundis, J. M. Arreola-Guerra, J. Alberu, M. I. Solis-G, L. Llorente, J. Granados, M. Vilatoba, R. Cruz-Martinez, L. Morales-Buenrostro, A. G. Contreras

    Instituto Nacional de Ciencias Medicas y Nutricion SZ, Mexico City, Mexico

    *Purpose: To determine the detection rate of IgG subclasses (IgGsc) and C3d-binding HLA-antibodies (abs) in a cohort of highly sensitized kidney transplant patients.*Methods: We evaluated,…
  • 2019 American Transplant Congress

    Validation of Gene Expression Signatures Associated with Antibody-Mediated Rejection (ABMR) in Renal Allograft Biopsies (Bx) of HLA-Sensitized Patients

    H. Zhang1, C. C. Nast2, N. Ammerman3, A. A. Vo3, S. C. Jordan3, M. Toyoda1

    1Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA, 2Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, 3Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: "Thoroughly validated gene transcripts” in renal Bx was adopted as one of the criteria for ABMR diagnosis in the latest Banff classification. Previously, we…
  • 2019 American Transplant Congress

    Vaccination And Allosensitization In Solid Organ Transplant Candidates

    L. Lourenco1, K. B. Bain2, L. Bowman3, D. C. Brennan4, G. A. Ewald5, R. R. Hachem6

    1Pharmacy, University of Chicago Medicine, Chicago, IL, 2Pharmacy, Barnes-Jewish Hospital, St. Louis, MO, 3Pharmacy, Tampa General Hospital, Tampa, FL, 4Internal Medicine, The Johns Hopkins School of Medicine, Baltimore, MD, 5Heart Failure and Heart Transplantation, Washington University School of Medicine, St. Louis, MO, 6Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO

    *Purpose: Clinical practice guidelines recommend vaccinating patients awaiting solid organ transplantation (SOT) against vaccine-preventable infections, but there is little evidence to suggest that vaccination reduces…
  • 2019 American Transplant Congress

    Rejection, Infectious, and Renal Outcomes with Perioperative Desensitization in Orthotopic Heart Transplant Recipients

    M. Plazak, B. Reed, S. Hammad, S. Gale, V. Ton, D. Kaczorowski, T. Trobiano, B. Ravichandran

    University of Maryland Medical Center, Baltimore, MD

    *Purpose: Pre-transplant allosensitization remains a significant barrier to organ allocation and a paucity of evidence exists to demonstrate the efficacy and safety of perioperative desensitization…
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