ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Highly-sensitized"

  • 2022 American Transplant Congress

    CIAT: A New Kidney Exchange Program with Better Options for Highly Sensitized and Long Waiting Patients

    M. d. Klerk1, J. Kal1, D. L. Roelen2, M. Betjes1, A. Weerd de1, M. Reinders1, M. Kho1, K. Glorie3, J. I. Roodnat1

    1Internal Medicine, Erasmus MC Transplant Institute, Rotterdam, Netherlands, 2Immunology, Leids UMC, Netherlands, 3Econometrics, EUR, Rotterdam, Netherlands

    *Purpose: A number of alternative, both living and deceased donor kidney transplant programs have been developed for incompatible pairs and difficult to match patients. The…
  • 2022 American Transplant Congress

    Evaluation of Hepatitis C Positive Donor to Hepatitis C Negative Recipient Kidney Transplant in a Highly Sensitized Patient Population

    A. T. Iaria, M. Martin, A. Hietpas, I. Tang, S. Koppe, I. Tzvetanov, E. Benedetti, C. Muran

    University of Illinois at Chicago, Chicago, IL

    *Purpose: This study assessed outcomes of hepatitis C virus (HCV) donor positive to recipient negative (D+/R-) kidney transplants (KT) in high immunologic risk patients. Literature…
  • 2022 American Transplant Congress

    Viral-Specific Cytotoxic T-Cell Responses in Hla-Sensitized Kidney Transplant Patients Maintained on Everolimus and Low Dose Tacrolimus

    R. Zhang1, S. Ge1, M. Chu1, J. Kahwaji2, A. Karasyov1, D. Lovato1, A. Vo2, J. Choi2, M. Toyoda1, S. Jordan2

    1Transplant Immunology Laboratory, Cedars Sinai Medical Center, Los Angeles, CA, 2Comprehensive Transplant Center, Cedars Sinai Medical Center, Los Angeles, CA

    *Purpose: Post-transplant immunosuppression with “everolimus + reduced dose tacrolimus” (Ev + Taclow) is reported to reduce the risk of viral infections compared to standard doses…
  • 2022 American Transplant Congress

    Stem Cell Donor-Derived CPRA Better Reflects Sensitization Than Current CPRA

    K. Lindblad1, C. Murphey2, P. Lalli3, J. Lunz4, L. Gragert5

    1UNOS, Richmnd, VA, 2Southwest Immunodiagnostics, Inc., San Antonio, TX, 3Carolinas Medical Center, Charlotte, NC, 4LifeLink Foundation Transplant Immunology Lab, Tampa, FL, 5Tulane University School of Medicine, New Orleans, LA

    *Purpose: The OPTN Histocompatibility Committee proposes replacing the current calculated panel reactive antibody (CPRA), based on HLA haplotype frequencies from ~14,000 deceased kidney donors, with…
  • 2021 American Transplant Congress

    Kidney Transplantation in Very Highly-Sensitized Patients with Maastricht Type III Non-heart-Beating Donors

    F. Villanego1, A. Mazuecos1, L. Vigara1, V. Lopez2, G. Bernal3, A. Rodriguez-Benot4, M. de Gracia5, P. Castro6, A. Alvarez6

    1Department of Nephrology, Hospital Puerta del Mar, Cadiz, Spain, 2Department of Nephrology, Hospital Carlos Haya, Malaga, Spain, 3Department of Nephrology, Hospital Virgen del Rocio, Sevilla, Spain, 4Department of Nephrology, Hospital Reina Sofia, Cordoba, Spain, 5Department of Nephrology, Hospital Virgen de las Nieves, Granada, Spain, 6Andalusian Transplant Coordination, Sevilla, Spain

    *Purpose: In 2012, a kidney transplant (KT) program for very highly-sensitized (VHS) patients (PRA ≥ 95%) based on virtual crossmatch began in Andalusia (Spanish region).…
  • 2021 American Transplant Congress

    Desensitization Using Costimulatory Blockade and Bortezomib to Prevent DSA Formation and Rejection in Reconstructive Transplantation

    B. Oh1, F. Messner2, Y. Guo1, G. Brandacher1

    1Johns Hopkins University School of Medicine, Baltimore, MD, 2Department of Visceral, Transplant and Thoracic Surgery, University of Innsbruck, Innsbruck, Austria

    *Purpose: Sensitization in form of donor-specific antibodies (DSA) and subsequent antibody-mediated rejection constitute some of the greatest risk factors for allograft rejection and long-term graft…
  • 2021 American Transplant Congress

    Desensitization Using Clazakizumab® (anti-il-6) in Highly-hla Sensitized Patients Awaiting Kidney Transplant (nct03380962)

    A. A. Vo1, N. Ammerman1, E. Huang1, M. Toyoda2, S. Ge2, A. Peng1, R. Najjar1, S. Sethi1, S. Williamson1, C. Myers1, K. Lim1, M. Gillespie1, S. Jordan1

    1Kidney Transplant, Cedars Sinai Medical Ctr, Los Angeles, CA, 2Transplant Immunology Laboratory, Cedars Sinai Medical Ctr, Los Angeles, CA

    *Purpose: IL-6 is a critical cytokine for plasma cell IgG production. Clazakizumab (CSL Behring LLC) is a humanized monoclonal aimed at the cytokine IL-6. Here…
  • 2021 American Transplant Congress

    Sensitized Lung Candidates Experience Reduced Access to Donor Organs

    K. Lindblad1, R. Goff2, D. Stewart2

    1UNOS, Richmond, VA, 2UNOS, Richmnd, VA

    *Purpose: Most studies of sensitization in transplant candidates have focused on kidney candidates, and unacceptable antigens (UAs) for non-kidney candidates are believed to be underreported.…
  • 2021 American Transplant Congress

    HLA Haplotype Frequency and Racial Disparities in Access to Transplant Among Highly Sensitized Kidney Transplant Candidates

    L. Gragert1, M. Kadatz2, D. Chang2, H. Gebel3, D. Stewart4, E. Kransdorf5, S. Brar2, S. Vaishnav2, J. Gill2, J. Lan2

    1Tulane University, New Orleans, LA, 2University of British Columbia, Vancouver, BC, Canada, 3Emory University, Atlanta, GA, 4UNOS, Richmond, VA, 5Cedars-Sinai, Beverly Hills, CA, Canada

    *Purpose: Despite implementation of the Kidney Allocation System (KAS) which prioritizes sensitized patients, sensitized Black individuals are less likely to receive a transplant than non-Black…
  • 2021 American Transplant Congress

    Safety and Tolerability of Tacrolimus Extended-Release (astagraf Xl) in Hla Sensitized Kidney Transplant Recipients: A Single Center Experience

    A. A. Vo, N. Ammerman, E. Huang, A. Peng, R. Najjar, S. Sethi, K. Lim, M. Gillespie, S. C. Jordan

    Cedars Sinai Medical Ctr, Los Angeles, CA

    *Purpose: Pill burden is a limitation in kidney transplant. Tacrolimus extended-release (Astagraf XL) is a once daily formulation approved for kidney transplantation. Increased compliance could…
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