Articles tagged "Highly-sensitized"

2015 American Transplant Congress
Differences in Reactivity of HLA-Specific Antibodies May Be Explained By Differences in Their Affinities for Selected Epitopes on HLA Proteins
S. Daga,^1,2 D. Lowe,⁶ R. Buchli,⁵ J. Collard,⁵ A. Mulder,⁸ C. McMurtrey,^4,5 H. Moyse,⁷ N. Evans,⁷ N. Krishnan,² W. Hildebrand,^4,5 F. Claas,⁸ D. Briggs,³ D. Zehnder,^1,2 D. Mitchell,¹ R. Higgins.^1,2
¹Clinical Sciences Research Laboratories, University of Warwick, Coventry, United Kingdom; ²Renal Unit, University Hospital, Coventry and Warwickshire NHS Trust, Coventry, United Kingdom; ³Department of Histocompatibility and Immunogenetics, NHS Blood and Transplant, Birmingham, United Kingdom; ⁴University of Oklahoma Health Science Center, Oklahoma City; ⁵Pure Protein LLC, Oklahoma City; ⁶Department of Histocompatibility and Immunogenetics, Royal Liverpool University Hospital, Liverpool, United Kingdom; ⁷School of Engineering, University of Warwick, Coventry, United Kingdom; ⁸Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands.
Affinity of IgG immunoglobulins for antigen varies and matures within the evolution of immune responses. Affinity is likely to be different for different epitope-antibody interactions…