ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Highly-sensitized"

  • 2015 American Transplant Congress

    Infectious Complications in ABO Incompatible Kidney Transplantation Recipient According to the Rituximab Dose

    J. Lee,1 J. Lee,1 S. Kim,2 M. Ju,1 D. Joo,1 M. Kim,1 S. Kim,1 Y. Kim,1 H. Kim,2 K. Huh.1

    1Department of Transplantation Surgery, Yonsei University Health System, Seoul, Republic of Korea; 2Department of Laboratory Medicine, Yonsei University Health System, Seoul, Republic of Korea.

    BackgroundDesensitization with rituximab and intravenous immunoglobulin improves ABO incompatible (ABOi) kidney transplantation (KT) outcomes. However, infections have been noted in association with rituximab administration. In…
  • 2015 American Transplant Congress

    Extended Analysis of Tocilizumab (anti-IL-6R) + Intravenous Immunoglobulin (IVIG) as Desensitization (DES) Agents for Reduction of Donor Specific Antibodies (DSA) in Patients Resistant to DES With IVIG + Rituximab

    A. Vo, J. Choi, I. Kim, J. Kahwaji, A. Peng, R. Villicana, S. Jordan.

    Kidney Transplant, Cedars-Sinai Medical Center, Los Angeles, CA.

    Introduction: IVIG+rituximab is an acceptable approach for DES with good outcomes. Despite this, ∼30% of patients fail DES, thus other approaches are needed. Options include…
  • 2015 American Transplant Congress

    Mesenchymal Stem Cells (MSCs) Transfusion for Desensitization of Positive Lymphocyte Cross Match (LCM) or Panel Reactive Antibodies (PRA) Before Kidney Transplantation – Outcome of 16 Cases

    G. Saadi,1 K. Eweda,2 M. Hassaballa,1 F. Fadel,3 E. Aziz,2 M. Roshdi,1 M. El Ansary,4 I. Aziz,4 W. Ismail,5 A. Atef,1 S. Hamid.4

    1Internal Medicine and Nephrology, Cairo University, Cairo, Egypt; 2Nephrology, Army Hospital, Cairo, Egypt; 3Pediatric Nephrology, Cairo University, Cairo, Egypt; 4Clinical Pathology, Cairo University, Cairo, Egypt; 5Pathology, Beni Sweif University, Beni Sweif City, Egypt.

    Immunomodulatory function of MSCs may correct positive PRA or LCM in highly-sensitized patients. We evaluate donor specific or 3rd party MSCs transfusion in 16 patients…
  • 2015 American Transplant Congress

    Quantifying the Survival Benefit of HLA-Incompatible Kidney Transplantation: A Multi-Center Study

    B. Orandi, X. Luo, A. Massie, J. Garonzik-Wang, B. Lonze, R. Ahmed, K. Van Arendonk, R. Montgomery, D. Segev.

    Surgery, Hopkins, Baltimore, MD.

    A single center study has demonstrated a two-fold survival benefit of incompatible live donor kidney transplant (ILDKT) compared to remaining on dialysis. We sought to…
  • 2015 American Transplant Congress

    Desensitization Protocol Including Concomitant Bortezomib and Rituximab Did Not Reduce Calculated PRA Nor Mean MFI Values Among Waitlisted Patients for Deceased Donor Kidney Transplantation

    S. Kang,1 H. Lim,1 J. Jeong,1 E. Song,2 I. Yun,3 C. Ahn,1 J. Yang.1

    1Transplantation Center, Seoul National University Hospital, Seoul, Korea; 2Department of Laboratory Medicine, Seoul National University Hospital, Seoul, Korea; 3Department of Surgery, Konkuk University, Seoul, Korea.

    Highly sensitized (HS) patients (pts) seldom have chance to receive deceased donor kidney transplant (DDKT). A desensitization (DES) program including bortezomib was employed to facilitate…
  • 2015 American Transplant Congress

    Long-Term Analysis of a Placebo-Controlled Trial of C1-INH for Prevention of Antibody-Mediated Rejection

    A. Vo, J. Choi, J. Kahwaji, D. Puliyanda, A. Peng, R. Villicana, S. Jordan.

    Kidney Transplant, Cedars-Sinai Medical Center, Los Angeles, CA.

    Introduction: Desensitization (DES) strategies focus primarily on antibody reduction using IVIG, rituximab ± PLEX to prevent DSA-induced antibody-mediated rejection (ABMR) and rebound B-cell activity. Recently,…
  • 2015 American Transplant Congress

    Comparison of One-Year Outcomes in High Risk Kidney Transplantation: ABO Incompatible and DSA Positive/CDC-AHG Negative

    N. Townamchai,1 W. Chancharoenthana,1 S. On-Pun,2 S. Wattanatorn,1 Y. Avihingsanon,1 K. Praditpornsilpa.1

    1Department of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand; 2Transfusion Medicine Unit, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.

    Back ground: Both donor specific anti-HLA antibody (DSA) and anti-ABO are the major barriers in kidney transplantation. We evaluated the outcomes of desensitization protocols in…
  • 2015 American Transplant Congress

    Etiology, Incidence and Outcomes of the Highly Sensitized Kidney Transplant Patient

    R. Redfield, T. Zens, J. Scalea, M. Rizzari, D. Mandelbrot, D. Kaufman, A. Djamali.

    University of Wisconsin, Madison, WI.

    Background: Sensitization to HLA antigens is a major barrier to kidney transplantation. We sought to determine the etiology, incidence and outcomes of kidney transplants performed…
  • 2015 American Transplant Congress

    Pre-Transplant Desensitization Protocol and Cancer Risk in Kidney Transplantation

    I. Revuelta,1,2,3 R. Ferreira,1 C. Canha,1 P. Piselli,4 D. Verdirosi,4 V. Tubita,2 E. De Sousa,1 F. Diekmann,1,2,3 M. Lozano,2,5 J. Cid,5 E. Palou,6 J. Martorell,6 A. Alcaraz,7 D. Serraino,8 F. Oppenheimer,1,2,3 J. Campistol.1,2,3

    1Renal Transplant Unit, Department of Nephrology and Kidney Transplant, Hospital Clinic, Barcelona, Spain; 2IDIBAPS, Barcelona, Spain; 3REDinREN. Carlos III Royal Institute. Ministry of Health, Madrid, Spain; 4Dipartamento di Epidemiologia e Ricerca Pre-Clinica, INMI “L. Spallanzani” IRCCC, Rome, Italy; 5Hemotherapy and Hemostasis, Hospital Clinic, Barcelona, Spain; 6Department of Immunology, Hospital Clinic, Barcelona, Spain; 7Department of Urology, Hospital Clinic, Barcelona, Spain; 8IRCCS Centro di Riferimento Oncologico, Aviano, Italy.

    Introduction: Desensitization (DS) in kidney transplant is a current therapy for all cause of incompatible living donor kidney transplants (LDKT). The impact in cancer risk…
  • 2015 American Transplant Congress

    The Impact of a Desensitization Protocol Using Plasmapheresis and Intravenous Immunoglobulin On Graft Outcome in Kidney Recipients With Donor Specific Anti-HLA Antibodies

    J. Junqueira, T. Leite, A. Junqueira, R. Esmeraldo.

    Hospital Geral de Fortaleza, Fortaleza, Brazil.

    Introduction: Kidney transplantation in patients with donor-specific anti-HLA antibodies (DSA) has been associated with a worse prognosis. The high cost, infectious complications and conflicting results…
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