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American Transplant Congress abstracts

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Articles tagged "Hepatitis C"

  • 2017 American Transplant Congress

    Occult Hepatitis C Virus in Recipients of Kidney Transplantation: Prevalence and Clinical Implications.

    C. Jimenez,1 T. Olea,1 M. Lopez,1 I. Castillo,2 J. Bartolomé,2 J. Quiroga,2 E. Gonzalez,1 V. Carreño,2 R. Selgas.1

    1Nephrology, Hospital Universitario La Paz/IdiPaz, Madrid, Spain; 2Instituto de Estudios Virales, Madrid, Spain

    Occult HCV infection (OCI) is characterized by the presence of HCV- RNA in liver or in peripheral blood mononuclear cells in the absence of serological…
  • 2017 American Transplant Congress

    Liver Allograft Hepatitis and Graft Loss After Hepatitis C Clearance.

    D. Bruno, S. Brown, S. Hanish, J. LaMattina, W. Hutson, S. Kottilil, W. Twadell, R. Barth.

    Surgery, University of Maryland School of Medicine, Baltimore, MD

    Successful HCV therapies should improve inferior outcomes of liver transplantation (LT) for HCV cirrhosis. We hypothesize certain patients may be predisposed to heterologous immunity that…
  • 2017 American Transplant Congress

    Post Transplant Outcomes in Hepatitis C Positive Patients.

    M. Lubetzky, N. Hayde, L. Kamal, M. Ajaimy, P. Bedi, G. Deboccardo, J. Rocca, S. Greenstein, J. Graham, A. Chokechanachaisakul, A. Courson, M. Kinkhabwala, E. Akalin.

    Montefiore Medical Center, Bronx

    Hepatitis C (HCV) is associated with increased morbidity and mortality after kidney transplant (KTx). We aimed to assess outcomes of HCV positive patients at our…
  • 2017 American Transplant Congress

    Transplantation of Hepatitis C Kidneys to Hepatitis C Recipients Confers Significantly Shorter Waiting Times in the Era of the New Kidney Allocation System.

    B. Concepcion, A. Langone, B. Edmundson, J. Johnson, A. Rajput, T. Johnson, D. Rybacki, D. Hale, R. Forbes.

    Nashville VA Medical Center, Nashville, TN

    Background: Prior to the new KAS, transplantation with HCV+ compared to HCV- kidneys provided shorter waiting times on the deceased donor list. In the current…
  • 2017 American Transplant Congress

    Pharmakokinetics of Daclatasvir, Sofosbuvir and GS-331007 in a Prospective Cohort of HCV Positive Kidney Transplant Recipients.

    E. Schrezenmeier,1 P. Galander,1 F. Hoffmann,2 C. Jaeger,2 J. Lisec,2 J. Schrezenmeier,2 O. Staeck,1 L. Lehner,1 D. Khadzhynov,1 F. Halleck,1 M. Duerr,1 K. Budde.1

    1Nephrology, Charite, Berlin, Deutschland, Germany; 2Molekulares Krebsforschungszentrum, Charite, Berlin, Deutschland (DEU), Germany

    BackgroundLimited data exist on the pharmacokinetic (PK) profile of novel direct acting antivirals in kidney transplant recipients (KTR). Here we report the PK of combinated…
  • 2017 American Transplant Congress

    Transplanting Hepatitis C Kidneys into Negative KidnEy Recipients [THINKER] Trial.

    D. Goldberg, E. Blumberg, R. Reddy, S. Nazarian, V. Van Deerlin, J. Trofe-Clarke, M. Levine, D. Sawinski, R. Bloom, P. Abt, P. Reese.

    University of Pennsylvania, Philadelphia

    Background: More than 500 kidneys from HCV+ deceased donors are discarded each year, even though direct acting antiviral therapies have cure rates exceeding 95%. We…
  • 2017 American Transplant Congress

    The Impact of Hepatitis C Treatment on GFR and Immunosuppression in Renal Transplant Recipients.

    J. Husson, R. Adekunle, B. Ravichandran, P. Mathur, S. Jonchhe, K. Stafford.

    University of Maryland Medical Center, Baltimore, MD

    Background: Renal transplant recipients (RTRs) with HCV are at an increased risk of graft rejection, making treatment of HCV in this population of the utmost…
  • 2017 American Transplant Congress

    EXPANDER-1: Exploring Renal Transplants Using Hepatitis-C Infected Donors for HCV-Negative Recipients.

    C. Durand, D. Brown, R. Wesson, N. Bhair, F. Naqvi, D. Ostrander, M. Bowring, A. Massie, S. Rasmussen, J. Sugarman, D. Segev, M. Sulkowski, N. Desai.

    JHU, Baltimore, MD

    Kidneys from hepatitis C-infected (HCV+) donors are underutilized in an era of severe organ shortage. In an effort to expand the donor pool, we evaluated…
  • 2017 American Transplant Congress

    Single-Center Initial Experience in Treating Chronic Hepatitis C in Kidney Transplant Recipients.

    G. Meinerz, C. da Silva, R. Bruno, E. Keitel, V. Garcia.

    Nephrology and Kidney Transplant Department, ISCMPA, Porto Alegre, RS, Brazil

    Chronic hepatitis C (HCV) infection is a prevalent condition in end-stage renal disease and presents an important clinical challenge in kidney transplant recipients (KTR). Interferon-based…
  • 2017 American Transplant Congress

    Use of Ledipasvir/Sofosbuvir with or without Ribavirin in Patients Post-Liver Transplant: Evaluation of Real-World Datasets.

    S. Flamm,1 M. Charlton,2 M. Manns,3 M. Prieto,4 I. Fernandez,5 M. Londono,6 R. Kwok,7 C. Smith,8 S. Lee,9 H. Ngo,9 A. Osinusi,9 A. Copans,9 L. Rossaro,9 M. Shoreibah,10 O. Massoud,10 M. Curry,11 M. Bourliere.12

    1Northwestern University, Chicago; 2Intermountain Medical Center, Murray; 3Hannover Medical School, Hannover, Germany; 4Hospital Universitari I Politecnic La Fe, Valencia, Spain; 5Hospital Universitario 12 de Octubre, Madrid, Spain; 6Servicio de Hepatología. Hospital Clinic, Barcelona, Spain; 7Walter Reed National Military Medical Center, DC; 8Medstar Georgetown University Hospital, Georgetown; 9Gilead Sciences, Inc., Foster City; 10University of Alabama Birmingham, Birmingham; 11Beth Israel Deaconess Medical Center, Boston; 12Hospital Saint Joseph, Marsielle, France

    PURPOSE: Post-liver transplant(LT) patients with HCV are considered a difficult-to-treat population. Ledipasvir/sofosbuvir(LDV/SOF) +ribavirin(RBV) for 12 weeks is approved in GT1 LT recipients based on the…
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