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Articles tagged "Hepatitis C"

  • 2019 American Transplant Congress

    The Treatment of Hepatitis C Virus (HCV) with Direct Acting Antiviral (DAA) Treatment in the Post Orthotopic Liver Transplant (OLT) Patient is Safe and Efficacious

    P. Brown1, Z. Demertzis1, S. Jafri2

    1Internal Medicine, Henry Ford Health System, Detroit, MI, 2Gastroenterology and Hepatology, Henry Ford Health System, Detroit, MI

    *Purpose: Chronic HCV is one of the leading causes for end stage liver disease and liver transplantation. Since their introduction, DAAs have revolutionized the treatment…
  • 2019 American Transplant Congress

    Impact of Donor Hepatitis C Virus Infection on Kidney Transplant Outcomes in the Direct Acting Antiretroviral Era: Time to Revise the KDPI?

    R. M. Cannon, E. G. Davis, L. Mackelaite, H. Dave, M. Eng, C. M. Jones

    University of Louisville, Louisville, KY

    *Purpose: The kidney donor risk index (KDRI), upon which the kidney donor profile index (KDPI) used for renal allocation is based, was derived before the…
  • 2019 American Transplant Congress

    Ultra-Short Duration Direct Acting Anti-Viral Prophylaxis to Prevent Virus Transmission from Hepatitis C Viremic Donors to Hepatitis C Negative Kidney Transplant Recipients

    G. Gupta, I. Yakubu, C. Bhati, A. Ferreira-Gonzalez, D. Kumar, I. Moinuddin, L. Kamal, A. King, M. Levy, A. Sharma, A. Coterell, T. Reichman, A. Khan, P. Kimball, R. Stiltner, M. Baldecchi, N. Brigle, T. Gehr, R. Sterling

    Virginia Commonwealth University, Richmond, VA

    *Purpose: Two recent pilot trials have shown that transplanting hepatitis C (HCV) viremic kidneys in to HCV negative recipients is feasible. These trials used 12…
  • 2019 American Transplant Congress

    Evaluating Hepatitis C Treatment after Solid Organ Transplantation

    A. J. Burgos1, R. Yau1, C. Tunwar2, J. A. Goss3, S. Khaderi3, N. L. Sussman4

    1Pharmacy, CHI St. Luke's Health-Baylor St. Luke's Medical Center, Houston, TX, 2CHI St. Luke's Health-Baylor St. Luke's Medical Center, Houston, TX, 3Division of Abdominal Transplantation, Baylor College of Medicine, Houston, TX, 4Abdominal Transplant & Liver Disease, Baylor College of Medicine, Houston, TX

    *Purpose: There is limited data on the use of direct acting antivirals for hepatitis C virus (HCV) in the solid organ transplant (SOT) population. The…
  • 2019 American Transplant Congress

    Longer-Term Outcomes for Hepatitis C Virus Negative Recipients of Kidneys from Hepatitis C Virus Nucleic Acid Test Positive Donors: The THINKER Trial

    P. Reese1, P. Abt1, E. Blumberg1, R. Bloom1, D. Sawinski1, P. Porrett1, A. Woodards1, K. Reddy1, V. van Deerlin1, R. Hasz2, M. Levine1, R. McLean1, A. Sicilia1, D. Goldberg1

    1University of Penn, Philadelphia, PA, 2Gift of Life, Philadelphia, PA

    *Purpose: Two trials of transplanting hepatitis C virus (HCV) nucleic acid test (NAT) positive kidneys into HCV-negative recipients have been published, both with 100% HCV…
  • 2019 American Transplant Congress

    Donate HCV Trial: Transplanting Thoracic Organs from Hepatitis C Donors to Uninfected Patients

    A. E. Woolley1, S. K. Singh2, H. J. Goldberg3, M. M. Givertz4, M. R. Mehra4, A. Coppolino, III5, V. Cheng1, J. Fanikos6, D. P. Harrington7, H. R. Mallidi2, L. R. Baden1

    1Infectious Diseases, Brigham and Womens Hospital, Boston, MA, 2Cardiac and Thoracic Surgery, Brigham and Womens Hospital, Boston, MA, 3Pulmonary, Brigham and Womens Hospital, Boston, MA, 4Cardiology, Brigham and Womens Hospital, Boston, MA, 5Thoracic Surgery, Brigham and Womens Hospital, Boston, MA, 6Pharmacy, Brigham and Womens Hospital, Boston, MA, 7Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA

    *Purpose: Given the need for thoracic organs and the high mortality of patients awaiting heart or lung transplantation, it is imperative to find ways to…
  • 2019 American Transplant Congress

    Listing Practices and Graft Utilization Lag behind Supply of Hepatitis C Positive Deceased Donors for Liver and Kidney Transplant

    C. E. Kling1, J. D. Perkins2, S. W. Biggins3, C. Johnson4, A. P. Limaye5, L. Sibulesky1

    1Division of Transplant Surgery, University of Washington Medical Center, Seattle, WA, 2Division of Transplant Surgery and Clinical and Bio-Analytics Transplant Laboratory, University of Washington Medical Center, Seattle, WA, 3Divisions of Gastroenterology and Hepatology and Center for Liver Investigation Fostering DiscovEry, University of Washington Medical Center, Seattle, WA, 4Division of Nephrology, University of Washington Medical Center, Seattle, WA, 5Division of Infectious Disease, University of Washington Medical Center, Seattle, WA

    *Purpose: The opioid epidemic resulted in increasing incidence of hepatitis C (HCV) in the general population and more deceased organ donors with HCV in the…
  • 2019 American Transplant Congress

    Transplantation of Kidneys from Hepatitis C Infected Donors to Hepatitis C Negative Recipients

    M. Z. Molnar, O. Cseprekal, M. Yazawa, M. Talwar, V. Balaraman, V. Mas, D. Maluf, R. Helmick, L. Campos, N. Nezakatgoo, C. Eymard, P. Horton, R. Verma, A. Jenkins, C. R. Handley, H. Snyder, C. Cummings, U. A. Agbim, B. Maliakkal, S. K. Satapathy, S. P. Nair, J. D. Eason

    Methodist University Hospital Transplant Institute, Memphis, TN

    *Purpose: There are no data on the safety of kidney transplantation from hepatitis C (HCV) NAT positive donors to HCV naïve recipients. We report the…
  • 2019 American Transplant Congress

    Early Achievement of Sustained Virological Response in Liver Transplant Recipients with Hepatitis C Reduces Risks of End Stage Renal Disease

    M. Yoshikawa1, T. Fukumoto2

    1Nephrology, Kobe University Hospital, Kobe, Japan, 2Hepato-Biliary-Pancreas Surgery, Kobe University Hospital, Kobe, Japan

    *Purpose: Chronic kidney disease (CKD) is common after liver transplantation (LT) and result worse morbidity and mortality. Hepatitis C virus (HCV) infection is recognized as…
  • 2019 American Transplant Congress

    Impact of DAA Treatment on Graft Fibrosis in HCV Positive Liver Transplantation

    J. Wellington1, A. Ma2, S. Kottilil3, J. Husson3, E. Wilson3, D. Bruno4

    1Gastroenterology & Hepatology, University of Maryland, Baltimore, MD, 2Internal Medicine, University of Maryland, Baltimore, MD, 3Institute of Human Virology, Division of Clinical Care and Research, University of Maryland, Baltimore, MD, 4Transplant Surgery, University of Maryland, Baltimore, MD

    *Purpose: Liver transplantation, LT, for HCV-related disease has the lowest five-year graft survival of all LT recipients, primarily due to accelerated fibrosis from unrestrained HCV…
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