2020 American Transplant Congress
Graft Perfusion with an Hsp90 Inhibitor Prolongs Graft Survival in Murine Heart Transplantation by Modulating Expression of Cyclin-Dependent Kinases and the Senolytic Effect
Department of Urology, Sapporo Medical University, Sapporo, Japan
*Purpose: We have previously demonstrated that administration of alvespimycin, a heat shock protein 90 (HSP90) inhibitor, prolongs the allograft survival in murine skin and heart…2019 American Transplant Congress
Graft Perfusion with Alvespimycin, an HSP90 Inhibitor, Suppresses IL-2 and IL-12p40 Production in Graft-Infiltrating Cells, Leading to Prolongation of Graft Survival in Murine Heart Transplantation
Department of Urology, Sapporo Medical University, Sapporo, Japan
*Purpose: We have previously demonstrated that administration of a heat shock protein 90 (HSP90) inhibitor prolonged the allograft survival in murine skin and heart transplantations.…2018 American Transplant Congress
Hsp70 Inhibitor Could Induce Transplant Tolerance through mTORC2/Akt Pathway
Hsp70, a highly conserved protein, has been shown to induce strong immune responses and to reduce inflammation. However, its mechanism is not clear, especially in…2018 American Transplant Congress
Graft Perfusion with Alvespimycin, an HSP90 Inhibitor, Suppresses Acute Allograft Rejection and Prolongs Graft Survival in Murine Heart Transplantation
Department of Urology, Sapporo Medical University, Sapporo, Japan.
Purpose: We have previously demonstrated that administration of a heat shock protein 90 (HSP90) inhibitor to recipients prolonged the allograft survival in murine skin and…2016 American Transplant Congress
Heat Shock Protein 90 Inhibitor 17DMAG Is a Potential New Therapeutic Agent Against Acute Allograft Rejection.
Purpose: We have previously demonstrated that Heat shock protein 90 (HSP90) plays a role in the development of acute rejection (AR) in organ transplantation. To…
American Transplant Congress abstracts