Articles tagged "Heart transplant patients"

2021 American Transplant Congress
The Pathology of Heart Allograft Biopsies: Discrepancies in Interpretation Between Conventional Histology and the Molecular Microscope Diagnostic (MMDx®) System
P. Randhawa¹, A. Seitz², Y. Huang¹, B. Feingold²
¹Department of Pathology, Pittsburgh, PA, ²Pediatrics, University of Pittsburgh, Pittsburgh, PA
*Purpose: There is growing interest in using transcriptomics to complement histologic evaluation of allograft hearts. The present study scrutinizes discrepancies between histologic and MMDx® systems…
2021 American Transplant Congress
Polyomavirus BK-Associated Nephropathy in Patients After Renal and Extrarenal Transplantation
A. Schwarz¹, J. Schmitz², J. Braesen², C. Bara³, M. Sauer⁴, H. Haller¹, J. Gottlieb⁵
¹Nephrology Department, Hannover Medical School, Hannover, Germany, ²Institute of Pathology, Hannover Medical School, Hannover, Germany, ³Department of Thoracic Surgery, Hannover Medical School, Hannover, Germany, ⁴Department of Pediatric Hematology, Hannover Medical School, Hannover, Germany, ⁵Deparment of Pneumology, Hannover Medical School, Hannover, Germany
*Purpose: Patients with non-renal organ transplantation (TX) may suffer BK-viral nephropathy (BKVN) of their own orthotopic kidneys. We aimed to know if these patients with…
2021 American Transplant Congress
Impact of Statin Intensity on the Incidence of Vascular Events and Graft Survival in Heart Transplant Recipients
E. Kim¹, I. Booth², R. Madathil³, B. Ravichandran¹, M. Demehin², M. Plazak²
¹University of Maryland School of Pharmacy, Baltimore, MD, ²Pharmacy, University of Maryland Medical Center, Baltimore, MD, ³University of Maryland School of Medicine, Baltimore, MD
*Purpose: Cardiac allograft vasculopathy (CAV) limits long-term graft survival of heart transplant (HT) recipients. In addition to decreased synthesis of cholesterol, statins also demonstrate immunomodulatory…
2021 American Transplant Congress
Improving Well-being for Heart Transplant Recipients: Implementation of a Patient Navigator Program
K. Ramonas, K. Ramonas
Health Navigator Foundation, San Francisco, CA
*Purpose: When surveyed, heart transplant recipients cited managing all their healthcare needs as a primary concern 83% of the time (n=23). To respond to this…
2021 American Transplant Congress
Assessing the Impact of Acute Major Adverse Kidney Events on Clinical Outcomes in Heart Transplant Recipients
J. E. Kelly¹, C. Perez¹, D. Taber¹, R. J. Tedford², B. McMahon², S. Alzaidi¹, H. B. Meadows¹
¹Pharmacy, MUSC Health, Charleston, SC, ²Medicine, MUSC Health, Charleston, SC
*Purpose: The purpose of this study was to elucidate contributors to the Major Adverse Kidney Events at 30 days (MAKE-30) outcome in heart transplant recipients…
2021 American Transplant Congress
Acute Dialysis, Mortality and Renal Failure After Heart Alone Transplant by Egfr and Dialysis Requirement in the United States
M. Aljuhani¹, T. Alexy¹, S. Jackson², C. Martin¹, R. Kandaswamy³, S. Riad¹
¹Medicine, University of Minnesota, Minneapolis, MN, ²Complex Care Analytics, Fairview Health Services, Minneapolis, MN, ³Surgery, University of Minnesota, Minneapolis, MN
*Purpose: We examined the early acute dialysis, 90-day mortality and one-year ESRD among OHT recipients by eGFR and dialysis requirement before transplantation.*Methods: Utilizing the SRTR…
2021 American Transplant Congress
Cyp3a5 Extensive Metabolizer Phenotype May be Associated with an Increase in Class 2 Donor Specific Antibodies and Antibody-Mediated Rejection
S. Mirza¹, N. Wilson², J. Van Zyl², P. Nguyen², T. Sam², S. Hall², M. Askar², R. Patel²
¹Texas Tech Univeristy Health Sciences Center Jerry H. Hodge School of Pharmacy, Dallas, TX, ²Baylor University Medical Center at Dallas, Dallas, TX
*Purpose: Tacrolimus (TAC) metabolism is highly dependent on CYP3A5, yet there is limited data on the effect of CYP3A5 genetic polymorphisms in heart transplant recipients…
2021 American Transplant Congress
Randomized Phase 3 Open-label Study of Maribavir vs Investigator-assigned Therapy for Refractory/resistant Cytomegalovirus Infection in Transplant Recipients: Subgroup Analyses of Efficacy by Organ
R. K. Avery¹, E. A. Blumberg², D. Florescu³, N. Kamar⁴, D. Kumar⁵, J. Wu⁶, A. Sundberg⁶
¹Johns Hopkins Hospital, Baltimore, MD, ²University of Pennsylvania, Philadelphia, PA, ³University of Nebraska School of Medicine, Omaha, NE, ⁴Hôpital de Rangueil, Toulouse, France, ⁵University Health Network, Toronto, ON, Canada, ⁶Shire Human Genetic Therapies, Inc., a Takeda company, Lexington, KY
*Purpose: Therapeutic options for refractory, with/without resistance (R/R), CMV infections are limited. We report organ type subgroup analyses from a large multi-center trial that studied…
2021 American Transplant Congress
The Co-Occurrence of Newly Developed HLA Donor Specific Antibody and Positive C3d/C4d Profiles Along with Immune Therapy Non-Compliance in Pediatric Heart Transplant Recipients is a High Risk Indicator for Patient Mortality
A. Zhang, C. Nasman, J. Allen, Y. Sun, D. Thomas, R. Rodriguez, C. Tan, G. Boyle
Cleveland Clinic Foundation Transplant Center, Cleveland, OH
*Purpose: Increasing evidence has implicated the deleterious effect of HLA donor specific antibody (DSA) in pediatric heart transplantation (PHTx). However, there are still insufficient research…
2020 American Transplant Congress
Variations in Recipient and Donor Clinical Characteristics between Heart Transplant Centers
W. T. McKinney¹, M. J. Bruin², S. Chu², D. Schladt³, J. Synder³, C. M. Martin⁴, T. Alexy⁴, B. L. Kasiske⁵, A. K. Israni¹
¹Nephrology, Hennepin Healthcare Research Institute, Minneapolis, MN, ²College of Design, University of Minnesota, Minneapolis, MN, ³Hennepin Healthcare Research Institute, Minneapolis, MN, ⁴Cardiology Division, University of Minnesota Department of Medicine, Minneapolis, MN, ⁵Department of Medicine, Hennepin Healthcare, Minneapolis, MN
*Purpose: When a patient has discretion over which heart transplant program will evaluate them for the waitlist, prior knowledge of program acceptance practices can enable…

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