ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Heart transplant patients"

  • 2015 American Transplant Congress

    Donor Age and Late Rejection Are Associated With the Development of Graft Coronary Artery Vasculopathy in Pediatric Heart Transplant Recipients

    W. Zuckerman, M. Richmond, T. Lee, L. Addonizio.

    Division of Pediatric Cardiology, Columbia University Medical Center, New York, NY.

    Purpose: Graft coronary artery vasculopathy (GCV) is one of the major causes of morbidity and mortality in pediatric heart transplant (HT) recipients, and in fact…
  • 2015 American Transplant Congress

    A Gene Expression Assessment for Improving Disease Activity and Stage in Heart ABMR

    A. Loupy, M. Racape, J. Reeve, J. Venner, S. Varnous, A. Gay, R. Guillemain, L. Hidalgo, C. Lefaucheur, X. Jouven, P. Bruneval, J. Duong, P. Halloran.

    Paris Transplant Group & ATAGC, Paris - Edmonton, France.

    BackgroundABMR is a major cause of heart transplant failure. The diagnosis of ABMR in heart transplantation is based on the 2013 ISHLT pAMR classification. We…
  • 2015 American Transplant Congress

    The Effects of Various Cardiac Preservation Solutions on Survival After Heart Transplantation

    C. Evans, K. Rajagopal, P. Sanchez, S. Rahimpour, F. Cheema, R. Pierson III, B. Griffith, S. Pham.

    Department of Surgery, Division of Cardiac Surgery, University of Maryland School of Medicine, Baltimore, MD.

    Purpose: The optimal cardiac preservation solution is still debated. The purpose of this study is to determine whether the type of cardiac preservation solution has…
  • 2015 American Transplant Congress

    Inverse Monocytic Subset Profile in Blood and Tissue During Heart Transplant Rejection

    T. van den Bosch,1 M. Kraaij,1 K. Caliskan,2 A. Constantinescu,2 O. Manintveld,2 P. Leenen,3 C. Baan,1 M. van Groningen,4 A. Rowshani.1

    1Department of Internal Medicine, Section Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, Netherlands; 2Department of Cardiology, Erasmus Medical Center, Rotterdam, Netherlands; 3Department of Immunology, Erasmus Medical Center, Rotterdam, Netherlands; 4Department of Pathology, Erasmus Medical Center, Rotterdam, Netherlands.

    Introduction: Increased monocytic infiltration of heart transplant tissue is documented during acute rejection. It is still unclear how changes in circulating monocyte pool relate to…
  • 2015 American Transplant Congress

    Dietary-Associated Trimethylamine N-Oxide (TMAO) Levels Is associated With Coronary Allograft Vasculopathy Following Heart Transplantation

    S. Zeltzer,1 Z. Wang,1 M. Askar,2 J. Coughlin,1 T. Hudec,1 D. Taylor,3 L. Li,1 R. Starling,3 S. Hazen,1 W. Tang.1

    1Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH; 2Transplant Center, Cleveland Clinic, Cleveland, OH; 3Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH.

    Background: Coronary allograft vasculopathy (CAV) is a leading cause of cardiac graft failure after 1 year post transplant. It is characterized by an inflammatory vascular…
  • 2015 American Transplant Congress

    Gene Expression Monitoring in Pediatric Heart Transplant Recipients

    C. Sutton,1 R. Butts,2 A. Burnette,3 A. Savage,2 W. Uber,1 A. Haney.1

    1Pharmacy, Medical University of South Carolina, Charleston, SC; 2Pediatric Cardiology, Medical University of South Carolina, Charleston, SC; 3Pediatric Heart Transplant, Medical University of South Carolina, Charleston, SC.

    Allomap® gene expression testing is a non-invasive screening tool approved for use in heart transplant recipients age 15 and older. Experience with Allomap® in pediatric…
  • 2015 American Transplant Congress

    Does Switching Predict Conversion: IgM De Novo Donor Specific HLA Antibodies Class Switch to IgG in Subclinical Antibody Mediated Rejection in Heart Transplant Recipients

    M. Askar,1 R. Rodriguez,1 L. Klingman,1 D. Thomas,1 A. Zhang,1 H. Morf,2 N. Hamon,1 N. Moazami,1 E. Hsich,1 D. Taylor,1 R. Starling,1 C. Tan.1

    1Cleveland Clinic, Cleveland; 2School of Medicine, Leipzig University, Leipzig, Germany.

    Background: Concomitant C4d and C3d detection in heart biopsies correlates with circulating DSA and graft dysfunction. Detection of C4d only in surveillance biopsies is not…
  • 2015 American Transplant Congress

    Evaluating the Benefits of Everolimus on Cardiac Allograft Vasculopathy: Further Evidence from Results of Imputations for Missing IVUS Data from A2310 Study

    P. Lopez,1 G. Dong,2 Z. Wang.2

    1Novartis Pharma AG, Basel, Switzerland; 2Novartis Pharmaceuticals, East Hanover, NJ; 3Novartis Pharmaceuticals, East Hanover, NJ.

    Purpose: A2310 IVUS study showed that everolimus (EVR) provides cardiac allograft vasculopathy (CAV) benefit compared to mycophenolate mofetil (MMF) by assessing the mean change in…
  • 2015 American Transplant Congress

    Biomarker Panel Profile for Identification of High-Risk Patients After Heart Transplantation

    M. Barten,1 M.-T. Dieterlen,2 J. Garbade,2 F. Mohr.2

    1Cardiovascular Surgery, Universisty Heart Center Hamburg, Hamburg, Germany; 2Cardiac Surgery, University Leipzig Heart Center, Leipzig, Germany.

    Background: The first year after cardiac transplantation is critical for transplant survival and long-term outcome. Identification of suitable biomarkers for detection of rejection processes is…
  • 2015 American Transplant Congress

    Incidence, Determinants and Outcome of Kidney Transplantation for End Stage Renal Disease After Heart Transplantation

    A. Grupper,1 A. Grupper,1 R. Daly,1 M. Hathcock,2 W. Kremers,2 F. Cosio,1 B. Edwards,1 S. Kushwaha.1

    1William J. von Liebig Transplant Center, Mayo Clinic, Rochester, MN; 2Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN.

    Objectives: Progressive renal failure is a frequent complication following heart transplantation (HTx), is generally attributed to calcineurin inhibitor (CNI) based immunosuppression, and may result in…
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