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American Transplant Congress abstracts

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Articles tagged "Heart transplant patients"

  • 2015 American Transplant Congress

    Correlation of Longitudinal Gene-Expression Profiling Score to Cytomegalovirus Infection: Results from the Outcomes AlloMap® Registry

    M. Kanwar,1 J. Yee,2 G. Ewald,3 S. Murali,1 J. Teuteberg.4

    1Allegheny Singer Research Institute, Pittsburgh, PA; 2CareDx, Inc., Brisbane, CA; 3Washington University, St. Louis, MO; 4University of Pittsburgh Medical Center, Pittsburgh, PA.

    Purpose: Cytomegalovirus (CMV) infection has been implicated in the pathogenesis of allograft rejection, which is reflected by high gene-expression profiling (GEP) scores. In the IMAGE…
  • 2015 American Transplant Congress

    The Impact of Administrating Everolimus Before Cytomegalovirus Infection to Prevent CMV Recurrence in Heart Transplant Recipients

    M. Ishida, K. Toda, T. Nakamura, S. Miyagawa, Y. Yoshikawa, S. Fukushima, S. Saito, D. Yoshioka, K. Kubota, T. Ueno, T. Kuratani, Y. Sawa.

    Cardiovascular Surgery, Osaka University, Suita, Osaka, Japan.

    Purpose – Cytomegalovirus (CMV) infection is a major complication in heart transplant recipients. Recent trials indicate that the use of the mammalian target of rapamycin…
  • 2015 American Transplant Congress

    Clinical Use of Gene-Expression Profiling to Monitor for Rejection After Cardiac Transplantation – Which Patients and When?

    J. Teuteberg,1 M. Shullo,1 T. Wolf,2 P. Prasad,2 G. Ewald.3

    1University of Pittsburgh Medical Center, Pittsburgh, PA; 2CareDx, Inc., Brisbane, CA; 3Washington University, St. Louis, MO.

    Background: Gene-expression profiling (GEP), in place of endomyocardial biopsy, is increasing. GEP testing is intended for low-risk asymptomatic patients (pts); thus, the profile of pts…
  • 2015 American Transplant Congress

    Clinically Relevant Wound Events With Everolimus-Based Immunosuppressive Regimen: Post-Hoc Analysis from a Randomized Heart Transplant Study

    A. Zuckermann,1 M. Rinaldi,1 N. Yonan,1 S.-S. Wang,1 G. Dong,2 P. Lopez.2

    1For the A2309 Study Group, Vienna, Austria; 2Novartis, Basel, Switzerland.

    Purpose: In the A2310 (NCT00300274) heart transplant (HTx) study with everolimus (EVR) vs mycophenolate mofetil (MMF), information on a broad spectrum of potential wound healing…
  • 2015 American Transplant Congress

    Prevalence and Outcomes of Heart Transplantation in Children With Intellectual Disability

    A. Wightman,1 H. Bartlett,1 Q. Zhao,2 J. Smith.3

    1Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI; 2Biostatistics, University of Wisconsin School of Medicine and Public Health, Madison, WI; 3Pediatrics, University of Washington School of Medicine, Seattle, WA.

    Background:Heart transplantation in children with intellectual disability (ID) is a controversial issue. Previous research on this population has been limited to small case reports.Objective:To describe…
  • 2015 American Transplant Congress

    Late Rejection in Pediatric Heart Transplantation: The Importance of Medical Adherence

    A. Letica, W. Zuckerman, L. Addonizio, J. McAllister, T. Lee, M. Richmond.

    Division of Pediatric Cardiology, Columbia University, New York, NY.

    While the incidence of early rejection (<1 yr post-transplant) after pediatric heart transplant (HT) has decreased, late rejection (> 1 yr post-transplant) remains a constant…
  • 2015 American Transplant Congress

    A New Diagnostic Tool for Antibody Mediated Rejection in Heart and Lung Transplantation: Intragraft Donor Specific Anti-HLA Antibodies Detection

    J. Olagne,1,2,3 A. Parissiadis,2 N. Froelich,2 S. Caillard,1 M.-P. Chenard,3 E. Epailly,4 H. Kremer,4 T. Degot,5 S. Hirschi,5 R. Kessler,5 B. Moulin.1

    1Service de Néphrologie - Transplantation, Centre Hospitalier Universitaire, Strasbourg, France; 2Laboratoire d'Histocompatibilité, Etablissement Français du Sang, Strasbourg, Alsace, France; 3Département de Pathologie, Centre Hospitalier Universitaire, Strasbourg, France; 4Service de Cardiologie, Centre Hospitalier Universitaire, Strasbourg, France; 5Service de Pneumologie, Centre Hospitalier Universitaire, Strasbourg, France.

    INTRODUCTION: Antibody mediated rejection (AMR) is one of the causes of dysfunction and graft loss. The limited histological features, with a weak sensibility of c4d,…
  • 2015 American Transplant Congress

    Prevalence, Risk Factors, and Clinical Management of Chronic Renal Dysfunction in Heart Transplant Recipients

    K. Xhima, O. Famure, Y. Li, J. Kim.

    Multi-Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, ON, Canada.

    Background: Chronic kidney disease (CKD) is a frequent complication after heart transplantation. The magnitude of post-transplant CKD makes it necessary to characterize patients at increased…
  • 2015 American Transplant Congress

    Long-Term Results After Heart Transplantation – A Randomized Trial Comparing Tacrolimus Versus Cyclosporine A in Combination With Mycophenolate Mofetil After a Mean Duration of 15 Years

    S. Guethoff,1 C. Grinninger,1 B. Reichart,2 P. Ueberfuhr,1 C. Hagl,1 B. Meiser.2

    1Department of Cardiac Surgery, Ludwig-Maximilians University, Munich, Germany; 2Transplantation Center, Ludwig-Maximilians University, Munich, Germany.

    Purpose. Development of cardiac allograft vasculopathy (CAV), renal dysfunction and malignancies are the main risks due to long-term immunosuppressive therapy after heart transplantation (HTx). We…
  • 2015 American Transplant Congress

    Tracking T Cell Fate After Antithymocyte Globulin (ATG) Immunotherapy in Infant Heart Transplant (HTx) Patients

    S.-I. Wang,1,2 I. Larsen,1,2 S. Urschel,1,2 R. Chinnock,3 J. Rusch,3 L. West.1,2

    1Univ. of Alberta, Edmonton, Canada; 2Alberta Transplant Institute, Edmonton, Canada; 3Loma Linda Univ., Loma Linda.

    Polyclonal T cell depletion with ATG is a common induction therapy in adult and pediatric transplantation. In adults, T cell recovery post-ATG involves homeostatic proliferation…
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