Articles tagged "Heart transplant patients"

2019 American Transplant Congress
Breaking Concepts: 10-year Follow-Up of the Everolimus versus Azathioprine Heart Transplant Multi-National Study
J. A. Kobashigawa¹, R. Starling², E. Passano¹, P. Bernhardt³, B. Azarbal¹, R. Cheng¹, F. Esmailian¹, K. Khush⁴, D. Mancini⁵, J. Patel¹, T. Sato¹, S. Varnous⁶
¹Smidt Heart Institute at Cedars-Sinai, Los Angeles, CA, ²Cleveland Clinic, Cleveland, OH, ³Novartis Pharmaceuticals, Basel, Switzerland, ⁴Stanford University, Palo Alto, CA, ⁵Mount Sinai, New York, NY, ⁶APHP, Pitié‐Salpétrière, Sorbonne University, Paris, France
*Purpose: This study is the 10-year follow-up of a randomized double-blind prospective trial that compared everolimus (1.5 mg or 3 mg) to azathioprine. In this…
2019 American Transplant Congress
The National Landscape of Heart Transplant Candidates with HIV
A. A. Shaffer¹, A. G. Thomas², D. L. Segev¹
¹Surgery & Epidemiology, Johns Hopkins University, Baltimore, MD, ²Epidemiology, University of North Carolina, Chapel Hill, NC
*Purpose: Heart disease is a leading cause of death for HIV+ individuals, and the number of HIV+ heart transplant (HT) recipients is growing. Although understanding…
2019 American Transplant Congress
Influence Of HLA-DR Mismatches On Long Term Outcomes Following Heart Transplantation
A. Singhvi, R. Araujo-Gutierrez, M. H. Park, A. Bhimaraj, B. H. Trachtenberg, I. Hussain, A. Guha
Division of Cardiology/ JC Walter Jr. Transplant Center, Houston Methodist Hospital, Houston, TX
*Purpose: In the field of kidney transplantation, there is strong support for the beneficial effect of minimizing donor-recipient HLA incompatibility, and HLA-DR matching in particular…
2019 American Transplant Congress
More Advanced Heart Failure Prior To Transplant May Influence The Cytomegalovirus Specific T Cell Response In Cytomegalovirus Positive Recipients.
U. López Cardoza, E. García, C. Díez, J. Roca, N. Sabé, N. Manito, I. Tatjer, A. Cequier, O. Bestard, J. González
Bellvitge Universitary Hospital, L' Hospitalet de Llobregat, Spain
*Purpose: Current assessment of risk of Cytomegalovirus (CMV) infection in CMV+ heart transplant (HT) recipients is poor. A diminished CMV-specific T cell response against 2…
2019 American Transplant Congress
Donor, Recipient Indices and Frailty Predict Outcomes after Heart-Kidney Transplantation
C. Beifeld¹, V. Dio Guardi¹, K. Lau¹, A. Di Carlo¹, S. Karhadkar²
¹Surgery, Temple University Hospital, Philadelphia, PA, ²Temple University Hospital, Philadelphia, PA
*Purpose: Simultaneous heart kidney transplantation (SHKT) is increasing in frequency; however there is a lack of consensus regarding patient selection criteria for this life saving…
2019 American Transplant Congress
Donate HCV Trial: Transplanting Thoracic Organs from Hepatitis C Donors to Uninfected Patients
A. E. Woolley¹, S. K. Singh², H. J. Goldberg³, M. M. Givertz⁴, M. R. Mehra⁴, A. Coppolino, III⁵, V. Cheng¹, J. Fanikos⁶, D. P. Harrington⁷, H. R. Mallidi², L. R. Baden¹
¹Infectious Diseases, Brigham and Womens Hospital, Boston, MA, ²Cardiac and Thoracic Surgery, Brigham and Womens Hospital, Boston, MA, ³Pulmonary, Brigham and Womens Hospital, Boston, MA, ⁴Cardiology, Brigham and Womens Hospital, Boston, MA, ⁵Thoracic Surgery, Brigham and Womens Hospital, Boston, MA, ⁶Pharmacy, Brigham and Womens Hospital, Boston, MA, ⁷Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA
*Purpose: Given the need for thoracic organs and the high mortality of patients awaiting heart or lung transplantation, it is imperative to find ways to…
2019 American Transplant Congress
Idarucizumab For The Reversal Of Dabigatran In Patients Undergoing Heart Transplantation
J. Van Keer¹, T. Vanassche¹, W. Droogne¹, S. Rex², F. Rega³, J. Van Cleemput¹, P. Verhamme¹, M. Naesens⁴
¹Cardiology, University Hospitals Leuven, Leuven, Belgium, ²Anesthesiology, University Hospitals Leuven, Leuven, Belgium, ³Cardiovascular Surgery, University Hospitals Leuven, Leuven, Belgium, ⁴Nephrology, University Hospitals Leuven, Leuven, Belgium
*Purpose: Atrial fibrillation is common among patients with advanced heart failure who are listed for transplantation. Idarucizumab is a monoclonal antibody fragment that was developed…
2019 American Transplant Congress
Clonal Composition And Single-cell Characterization Of T-cell Infiltrates In Cardiac Allograft Vasculopathy
M. V. Habal¹, A. Myung², H. Yan², S. Rao², S. Lin², S. See², P. Roy², R. Shihab², C. Marboe³, S. Restaino¹, A. Han², M. Givertz⁴, J. C. Madsen⁵, L. Addonizio¹, M. Farr¹, E. Zorn²
¹Cardiology, Columbia University Medical Center, New York, NY, ²Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, ³Pathology, Columbia University Medical Center, New York, NY, ⁴Cardiology, Brigham and Women's Hospital, Boston, MA, ⁵Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: T-cells are implicated in the pathogenesis of cardiac allograft vasculopathy (CAV), yet their clonal composition and function are incompletely defined. We examined the T-cell…
2019 American Transplant Congress
Immune Privilege May Predispose Patients after Orthotopic Heart Transplantation to Develop Recipient to Donor Atrial Connections Associated with Atrial Arrhythmias
B. Herweg¹, M. Nellaiyappan¹, T. Tran¹, G. Mabry¹, K. Weston¹, H. J. Eisen², M. Weston³
¹Cardiovascular Sciences, University of South Florida Morsani College of Medicine, Tampa, FL, ²Heart and Vascular Institute, Pennsylvania State University, Hershey, PA, ³Tampa General Hospital, Tampa, FL
*Purpose: The formation of functional electrical inter-atrial connections (IAC) between recipient and donor atria after orthotopic heart transplantation (OHT) is intriguing and its mechanism is…
2019 American Transplant Congress
Syphilis Transmission in Solid Organ Transplantation
M. Morrison, M. Hurtik, G. M. Lyon, S. Pouch
Emory University Hospital, Atlanta, GA
*Purpose: Syphilis is a sexually transmitted infection that affects people worldwide. While transmission generally occurs via sexual contact, other modes of transmission are possible, including…