ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Graft-infiltrating lymphocytes"

  • 2022 American Transplant Congress

    Local Cognate Antigen in Kidney Allografts Promotes Tissue Resident Memory T Cell Maintenance

    R. Tieu1, Q. Zeng1, D. Zhao1, P. Manandhar2, A. Williams1, K. Abou-Daya1, L. Kane2, W. Shlomchik1, M. Oberbarnscheidt1, F. Lakkis1

    1Starzl Transplantation Institute, Pittsburgh, PA, 2Department of Immunology, University of Pittsburgh, Pittsburgh, PA

    *Purpose: Our lab has demonstrated that tissue resident memory T cells (TRM cells) sustain chronic kidney allograft rejection in mice. It remains unknown how TRM…
  • 2022 American Transplant Congress

    Perioperative IL-6 Blockade Promotes Intra-Graft Regulation and Prevents Costimulation-Blockade Resistant Rejection

    M. Muckenhuber1, K. Mengrelis1, A. M. Weijler1, V. Kainz1, R. Steiner1, H. Regele2, T. Wekerle1

    1Dept. of General Surgery, Div. of Transplantation, Medical University of Vienna, Vienna, Austria, 2Dept. of Pathology, Medical University of Vienna, Vienna, Austria

    *Purpose: Our group has recently shown that CTLA4-Ig monotherapy leads to limited murine heart allograft survival associated with decreased Treg frequencies and early acute T-cell…
  • 2022 American Transplant Congress

    IL-15 Signaling is Required for the Maintenance of Tissue Resident Memory T Cells in Chronic Allograft Rejection

    R. Tieu1, Q. Zeng1, D. Zhao1, A. Williams1, J. Yun Tso2, F. Lakkis1, J. Yun Tso2

    1Starzl Transplantation Institute, Pittsburgh, PA, 2JN Biosciences, Mountain View, CA

    *Purpose: Currently, no immunotherapies have been clinically proven to prevent or treat chronic rejection. IL-15 is known to support memory T cell homeostasis. However, it…
  • 2022 American Transplant Congress

    Donor Exercise Preconditioning Protects Murine Orthotopic Liver Grafts During Ischemia Reperfusion Injury

    H. O. Yazdani, C. Kaltenmeier, R. Nakano, R. L. Simmons, D. A. Geller, S. Tohme

    Surgery, University of Pittsburgh Medical Center, Pissburgh, PA

    *Purpose: Orthotopic liver transplantation (LTx) serves as the gold standard of care in patients with end-stage liver disease. However, a major obstacle to the immediate…
  • 2022 American Transplant Congress

    Allograft TLR9 is Required for Endogenous Donor-Reactive Memory CD8 T Cell Activation in High-Risk Cardiac Allografts to Mediate CTLA-4Ig Resistant Graft Rejection

    E. H. Koritzinsky, D. Ueda, H. Tsuda, S. Miyari, R. L. Fairchild

    Inflammation and Immunity, Cleveland Clinic, Cleveland, OH

    *Purpose: Prolonged allograft cold ischemic storage (CIS) and subsequent increased ischemia-reperfusion injury (IRI) following solid organ transplant act through innate immune pathways that promote early…
  • 2022 American Transplant Congress

    The Roles of Intrarenal B Cells in Regulating Antibody Mediated Rejection After Kidney Transplantation

    H. Zhang1, C. Cavazzoni1, E. Bechu1, B. Hanson1, M. A. Podestà1, D. Kreisel2, A. Alessandrini3, P. Sage1

    1Transplantation Research Center, Renal Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 2Department of Surgery, Washington University in St Louis, St. Louis, MO, 3Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard, Boston, MA

    *Purpose: Alloimmune rejection after kidney transplantation is associated with substantial infiltration of immune cells such as T and B cells in transplanted grafts. However, the…
  • 2022 American Transplant Congress

    Effector T Cells Potentiate Treg Migration to Allografts

    H. Baydoun, M. Fathallah, A. Pena, B. Robinson, G. Camirand

    Surgery and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA

    *Purpose: CD4+ regulatory T cells (Treg) maintain transplantation tolerance through the suppression of immunity in both secondary lymphoid organs and allografts. However, the signals promoting…
  • 2022 American Transplant Congress

    Single Cell RNAseq Analysis of Human Renal Allograft Rejection Demonstrates Distinct Transcriptomic Profiles That Vary Based on the Type of Maintenance Immunosuppression

    T. Shi1, A. Burg1, K. Roskin2, J. Rush3, B. Haraldsson3, A. Shields4, R. Alloway4, E. Woodle5, D. Hildeman1

    1Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 3Novartis Pharmaceuticals AG, Basel, Switzerland, 4Internal Medicine, University of Cincinnati, Cincinnati, OH, 5Surgery, University of Cincinnati, Cincinnati, OH

    *Purpose: Rejection therapy has remained unchanged for 60 years and is associated with significant failure and infection rates. Development of new anti-rejection therapies requires mechanistic…
  • 2022 American Transplant Congress

    Effect of CD8+ Cell Depletion in Treg Mediated Skin Graft Survival

    R. Steiner1, A. M. Weijler1, M. Muckenhuber2, J. Sprent3, T. Wekerle4, N. Pilat1

    1Medical University of Vienna, Vienna, Austria, 2Dept. of General Surgery, Div. of Transplantation, Medical University of Vienna, Vienna, Austria, 3Garvan Institute of Medical Research, Sydney, Australia, 4Vienna Gen Hosp / Medical Univ of Vienna, A-1090 Vienna, Austria

    *Purpose: The selective in vivo expansion and activation of regulatory T cells via administration of interleukin-2 (IL-2) coupled to a specific antibody against IL-2 (IL-2…
  • 2021 American Transplant Congress

    Characterisation of Distinct Graft Infiltrates Following Cellular Therapy in Kidney Transplant Recipients

    M. O. Brook1, P. N. Harden2, I. Roberts2, W. R. Mulley3, J. Hester1, M. E. Reinders4, F. Issa1

    1Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, 2Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom, 3Department of Nephrology, Monash Medical Centre, Melbourne, Australia, 4Division of Nephrology and Transplant Center, Leiden University Medical Center, Leiden, Netherlands

    *Purpose: Cellular therapy is an emerging treatment in the field of clinical transplantation with the potential to improve both short and long-term transplant outcomes. We…
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