2022 American Transplant Congress
The Roles of Intrarenal B Cells in Regulating Antibody Mediated Rejection After Kidney Transplantation
*Purpose: Alloimmune rejection after kidney transplantation is associated with substantial infiltration of immune cells such as T and B cells in transplanted grafts. However, the…2022 American Transplant Congress
Effector T Cells Potentiate Treg Migration to Allografts
Surgery and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA
*Purpose: CD4+ regulatory T cells (Treg) maintain transplantation tolerance through the suppression of immunity in both secondary lymphoid organs and allografts. However, the signals promoting…2022 American Transplant Congress
Single Cell RNAseq Analysis of Human Renal Allograft Rejection Demonstrates Distinct Transcriptomic Profiles That Vary Based on the Type of Maintenance Immunosuppression
*Purpose: Rejection therapy has remained unchanged for 60 years and is associated with significant failure and infection rates. Development of new anti-rejection therapies requires mechanistic…2022 American Transplant Congress
Effect of CD8+ Cell Depletion in Treg Mediated Skin Graft Survival
*Purpose: The selective in vivo expansion and activation of regulatory T cells via administration of interleukin-2 (IL-2) coupled to a specific antibody against IL-2 (IL-2…2022 American Transplant Congress
Local Cognate Antigen in Kidney Allografts Promotes Tissue Resident Memory T Cell Maintenance
*Purpose: Our lab has demonstrated that tissue resident memory T cells (TRM cells) sustain chronic kidney allograft rejection in mice. It remains unknown how TRM…2022 American Transplant Congress
Perioperative IL-6 Blockade Promotes Intra-Graft Regulation and Prevents Costimulation-Blockade Resistant Rejection
*Purpose: Our group has recently shown that CTLA4-Ig monotherapy leads to limited murine heart allograft survival associated with decreased Treg frequencies and early acute T-cell…2022 American Transplant Congress
IL-15 Signaling is Required for the Maintenance of Tissue Resident Memory T Cells in Chronic Allograft Rejection
1Starzl Transplantation Institute, Pittsburgh, PA, 2JN Biosciences, Mountain View, CA
*Purpose: Currently, no immunotherapies have been clinically proven to prevent or treat chronic rejection. IL-15 is known to support memory T cell homeostasis. However, it…2022 American Transplant Congress
Donor Exercise Preconditioning Protects Murine Orthotopic Liver Grafts During Ischemia Reperfusion Injury
Surgery, University of Pittsburgh Medical Center, Pissburgh, PA
*Purpose: Orthotopic liver transplantation (LTx) serves as the gold standard of care in patients with end-stage liver disease. However, a major obstacle to the immediate…2022 American Transplant Congress
Allograft TLR9 is Required for Endogenous Donor-Reactive Memory CD8 T Cell Activation in High-Risk Cardiac Allografts to Mediate CTLA-4Ig Resistant Graft Rejection
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Prolonged allograft cold ischemic storage (CIS) and subsequent increased ischemia-reperfusion injury (IRI) following solid organ transplant act through innate immune pathways that promote early…2021 American Transplant Congress
Characterisation of Distinct Graft Infiltrates Following Cellular Therapy in Kidney Transplant Recipients
*Purpose: Cellular therapy is an emerging treatment in the field of clinical transplantation with the potential to improve both short and long-term transplant outcomes. We…
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